DECOZAL 0.1% Price

Overview

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This medicine contains an important and useful components, as it consists of
Xylometazoline HClis available in the market in concentration

Name

Xylometazoline Hydrochloride 0.1% Nasal prep

Precaution

Before using **Xylometazoline Hydrochloride 0.1% Nasal Prep**, it is essential to seek guidance from a healthcare provider to ensure the medication is appropriate for the individual. The following precautions should be observed: - **Prolonged Use**: Xylometazoline should not be used for more than **3 consecutive days**. Prolonged usage can lead to **rebound congestion**, a condition known as **rhinitis medicamentosa**, where nasal congestion worsens after stopping the medication. - **Pre-existing Health Conditions**: People with **high blood pressure**, **heart conditions**, **glaucoma**, or **thyroid problems** should exercise caution, as the medication can cause systemic absorption and exacerbate these conditions. - **Pregnancy**: Xylometazoline is generally considered safe during pregnancy if used in **small doses** and for **short durations**. However, it is crucial to use it only under the guidance of a healthcare provider, as its safety during pregnancy has not been definitively established. - **Lactation**: There is limited information on whether xylometazoline passes into breast milk. It should only be used during breastfeeding after consulting a doctor. - **Children**: Xylometazoline nasal sprays are typically not recommended for children under **2 years** of age. Use in children should be based on medical advice due to the risk of adverse reactions like **CNS stimulation** or **rebound congestion**.

Indication

**Xylometazoline Hydrochloride 0.1% Nasal Prep** is primarily used to relieve nasal congestion, and it can be prescribed for: - **Nasal Congestion**: It is commonly used to treat nasal congestion resulting from **allergic rhinitis**, **sinusitis**, the **common cold**, and **hay fever**. - **Sinus Pressure**: It reduces the discomfort and pressure associated with **sinus infections** by opening up blocked nasal passages and allowing the sinus cavities to drain. - **Pre-Operative Decongestion**: Before certain **nasal surgeries** or **procedures**, it may be used to shrink swollen nasal tissues and improve access to the nasal passages.

Contra indication

**Xylometazoline Hydrochloride 0.1% Nasal Prep** should not be used in the following situations: - **Hypersensitivity to Xylometazoline**: If a person is allergic to xylometazoline or any other ingredient in the nasal spray, they should avoid using it. - **Severe Cardiovascular Disorders**: Individuals with severe **hypertension**, **tachycardia**, or any **heart disease** should avoid xylometazoline due to its potential to increase blood pressure and heart rate. - **Glaucoma**: Xylometazoline is contraindicated in patients with **narrow-angle glaucoma** as it may increase intraocular pressure. - **Rhinitis Medicamentosa**: It should not be used by individuals who have developed **rebound congestion** (rhinitis medicamentosa) after prolonged use of nasal decongestants. - **Children Under 2 Years**: The nasal spray is contraindicated in children under **2 years** of age due to the risk of side effects.

Side Effect

Common and severe side effects associated with **Xylometazoline Hydrochloride 0.1% Nasal Prep** include: - **Common Side Effects**: - **Nasal Irritation**: **Dryness**, **stinging**, or **burning** in the nose is a common side effect. - **Sneezing**: Some users may experience sneezing after using the nasal spray. - **Rebound Congestion**: If used for more than **3 days**, rebound congestion may occur, making nasal congestion worse once the medication is stopped. - **Severe Side Effects**: - **Hypertension**: Xylometazoline can increase **blood pressure**, potentially causing **hypertension** in susceptible individuals. - **Tachycardia**: Increased **heart rate** or **palpitations** may occur, particularly in people with existing heart conditions. - **Central Nervous System Effects**: Some people may experience **nervousness**, **restlessness**, or **insomnia**, especially with excessive or prolonged use. - **Severe Allergic Reactions**: Although rare, symptoms such as **swelling**, **difficulty breathing**, or **rash** may indicate an allergic reaction and require immediate medical attention.

Pregnancy Category ID

3

Mode of Action

Xylometazoline is a **sympathomimetic decongestant** that acts by stimulating the **alpha-adrenergic receptors** in the smooth muscles of the blood vessels in the nasal mucosa. This leads to **vasoconstriction**, or the narrowing of the blood vessels, which reduces blood flow to the swollen nasal tissues, resulting in **decreased swelling and congestion**. As a result, nasal airways are opened, and the symptoms of **nasal congestion** are alleviated. - **Vasoconstriction**: The primary mechanism of action of xylometazoline is its ability to induce vasoconstriction, reducing blood flow to the mucosa and shrinking swollen tissue. - **Decreased Edema**: By reducing the fluid accumulation in the nasal passages, xylometazoline reduces **nasal edema**, allowing for better airflow and drainage of mucus.

Interaction

**Xylometazoline Hydrochloride 0.1% Nasal Prep** can interact with certain medications, and such interactions may affect its safety and efficacy: - **Other Vasoconstrictors**: When used with other **sympathomimetic** drugs (e.g., **phenylephrine**, **ephedrine**), there is an increased risk of elevated **blood pressure** and cardiovascular side effects. - **Monoamine Oxidase Inhibitors (MAOIs)**: The combination of xylometazoline with **MAO inhibitors** (such as **phenelzine** or **tranylcypromine**) may lead to a **hypertensive crisis**, a serious increase in blood pressure. These medications should not be used together. - **Antihypertensive Drugs**: The effectiveness of **antihypertensive** drugs (such as **beta-blockers**) may be compromised by the use of xylometazoline, which can increase blood pressure. - **Antidepressants**: Use with **tricyclic antidepressants** or **SNRIs** may increase the likelihood of **cardiovascular effects** like tachycardia or hypertension.

Pregnancy Category Note

Information not available

Adult Dose

The typical dosage for **Xylometazoline Hydrochloride 0.1% Nasal Prep** in adults is: - **1-2 sprays in each nostril**, as needed, usually every **8 to 10 hours**. - **Do not exceed 3 consecutive days** of use to avoid the risk of **rebound congestion** (rhinitis medicamentosa) or other side effects such as **hypertension** and **tachycardia**. - This medication should be used for short-term relief of nasal congestion and should not be used for extended periods.

Child Dose

For children, **Xylometazoline Hydrochloride 0.1% Nasal Prep** should only be used with medical advice, as the dosage may differ: - **Children (2-12 years)**: The usual dose is **1 spray in each nostril**, not to exceed **2 times daily** (morning and evening). The medication should only be used for **short durations** (no longer than 3 days) to prevent rebound congestion. - **Children under 2 years**: This medication is **not recommended** for children under **2 years** of age due to the increased risk of side effects like **CNS stimulation** and **rebound congestion**. --- As with any medication, it is vital to **consult a healthcare provider** before initiating treatment with **Xylometazoline Hydrochloride 0.1% Nasal Prep**. This ensures the medication is suitable for your individual health needs and minimizes the risk of adverse effects.

Renal Dose

There are no specific dose adjustments required for **renal impairment** with **Xylometazoline Hydrochloride 0.1% Nasal Prep**. However, individuals with severe kidney problems should use the medication with caution and under medical supervision, as the medication could be absorbed into the bloodstream and affect overall cardiovascular health.

Administration

Information not available