PERGOVERIS 150 IU/75 IU Price

Overview

Welcome to Dwaey, specifically on PERGOVERIS 150 IU/75 IU page.
This medicine contains an important and useful components, as it consists of
Follitropin alfa, Lutropin alfais available in the market in concentration

Name

Carboxymethylcellulose Sodium + Glycerine Eye prep

Precaution

- **Special Populations**: Carboxymethylcellulose Sodium + Glycerine eye preparations are generally safe for use in pregnant and breastfeeding women. However, as with all medications, it is advisable to consult a healthcare provider before use, especially during pregnancy. The preparation is considered to have low systemic absorption, making it unlikely to cause significant adverse effects in these populations. In pediatric patients, the eye preparation can be used with appropriate supervision, though the risk of misuse or incorrect application must be considered. Caution is also needed for patients with known allergies to any of the ingredients in the preparation. - **Monitoring Parameters**: Regular monitoring is not typically required for most patients using this product unless they have underlying eye conditions. If symptoms of dry eye persist or worsen despite use of the eye drops, patients should be evaluated for underlying conditions, such as eye infections or glaucoma. Also, monitoring for any signs of local irritation or hypersensitivity (e.g., redness, itching, or swelling) is important. - **Misuse or Dependency**: There is no known risk of misuse or dependency associated with Carboxymethylcellulose Sodium + Glycerine eye drops. However, overuse or excessive application can lead to increased eye irritation or discomfort. It is essential to follow recommended dosing schedules and avoid prolonged use without professional guidance.

Indication

- **Primary Indications**: Carboxymethylcellulose Sodium + Glycerine is primarily indicated for the management of dry eye conditions, including dry eye syndrome, which can be caused by environmental factors (like wind, smoke, or air conditioning), medical conditions (such as Sjögren’s syndrome), or medication use (e.g., antihistamines, diuretics). This combination is used to lubricate the surface of the eye, providing relief from symptoms like dryness, irritation, and discomfort. - **Evidence-Based Context**: Clinical studies have demonstrated that Carboxymethylcellulose Sodium is effective as a lubricant for dry eyes, as it mimics the natural tears and helps to maintain moisture on the ocular surface. Glycerine also contributes to moisture retention and provides additional hydration. This combination is commonly recommended as first-line therapy for mild to moderate dry eye disease by ophthalmology associations, including the American Academy of Ophthalmology (AAO). - **Off-label Uses**: Carboxymethylcellulose Sodium + Glycerine eye preparations are sometimes used off-label to alleviate discomfort caused by contact lens wear, following eye surgery (such as LASIK), or as adjunctive therapy for eye irritation caused by allergies or environmental factors.

Contra indication

- **Exclusion Criteria**: This eye preparation should not be used by individuals with known hypersensitivity or allergy to any of the ingredients in the formulation, including Carboxymethylcellulose Sodium or Glycerine. It should not be applied to eyes with active infections (e.g., bacterial, viral, or fungal conjunctivitis), as it may not be sufficient to treat or prevent infection and could potentially exacerbate the condition. - **Rationale**: The contraindication in patients with known allergies to any of the components is based on the risk of severe allergic reactions, including eye redness, swelling, itching, or discomfort. In cases of eye infection, using lubricants without proper antimicrobial treatment may lead to delayed healing and worsening of the condition. - **Age Restrictions**: There are no specific age restrictions for this product, but it should be used cautiously in infants or young children, who may have difficulty following instructions for use. It is essential to ensure proper application to avoid risk of contamination or accidental ingestion.

Side Effect

- **Common Side Effects**: The most common side effects of Carboxymethylcellulose Sodium + Glycerine eye drops are mild and typically include temporary blurred vision, stinging, or irritation upon application. These side effects usually subside after a few moments and are not typically cause for concern. - **Serious Side Effects**: Although rare, some individuals may experience more serious side effects such as allergic reactions, including redness, swelling, or itching of the eyes. In very rare cases, overuse or incorrect application may lead to eye infections or exacerbation of pre-existing eye conditions. - **Mitigation and Monitoring**: If irritation or other adverse reactions occur, it is recommended to discontinue use and consult a healthcare provider. If allergic symptoms like swelling, redness, or difficulty in breathing develop, emergency medical attention is required. To reduce side effects, it is important to follow the prescribed dosage and avoid touching the dropper tip to any surface to maintain the sterile nature of the product.

Pregnancy Category ID

0

Mode of Action

- **Mechanism**: Carboxymethylcellulose Sodium acts as a synthetic tear substitute that provides lubrication to the ocular surface. It binds to the epithelial cells on the surface of the eye, helping to form a stable tear film and prevent evaporation. This increases the moisture level in the eye, thus reducing irritation and dryness. Glycerine, a humectant, helps to attract and retain moisture, further hydrating the ocular surface and providing longer-lasting relief. - **Pharmacodynamics and Pharmacokinetics**: Carboxymethylcellulose Sodium and Glycerine work locally on the surface of the eye. These compounds do not penetrate the eye deeply or enter systemic circulation in significant amounts, which minimizes the risk of systemic side effects. The formulation’s pharmacokinetics involve the retention of moisture on the eye’s surface, preventing rapid evaporation and maintaining tear film stability. - **Distinctive Action**: The combination of Carboxymethylcellulose and Glycerine is particularly beneficial because it not only lubricates the eye but also helps restore the tear film, which is crucial for eye comfort and protection. This makes it effective in managing dry eye symptoms, particularly in individuals who have insufficient natural tear production or increased tear evaporation.

Interaction

- **Drug-Drug Interactions**: Carboxymethylcellulose Sodium + Glycerine eye drops are generally considered safe for use with other ophthalmic medications. However, when used in combination with other eye drops, there should be a waiting period between the administration of different preparations to avoid interference with their absorption and efficacy. It is recommended to wait at least 5-10 minutes between the application of different eye medications. - **Food and Alcohol Interactions**: There are no known food or alcohol interactions with this eye preparation. However, alcohol can exacerbate dry eyes and reduce the effectiveness of lubrication, so patients are advised to avoid alcohol consumption if they are using eye drops for dry eye relief. - **Clinical Recommendations**: For patients using multiple eye preparations, it is important to apply the drops in the correct order. Typically, the lubricant should be used last, as it helps to ensure that other medications remain in contact with the eye surface longer. Patients should avoid touching the tip of the dropper to the eye or any other surface to prevent contamination.

Pregnancy Category Note

Information not available

Adult Dose

- **Standard Dosage**: The typical adult dose for Carboxymethylcellulose Sodium + Glycerine eye drops is one or two drops applied to each affected eye, as needed, typically up to 4 times a day or as directed by a healthcare provider. The frequency of application may vary based on the severity of the symptoms and the individual’s specific condition. - **Administration**: The eye drops should be instilled directly into the eye, following proper hand hygiene and ensuring the dropper tip does not come into contact with the eye or other surfaces to avoid contamination. - **Maximum Dosage**: There is no specific maximum dosage for Carboxymethylcellulose Sodium + Glycerine, but it should be used as needed to relieve dry eye symptoms. Overuse may result in excessive lubrication, leading to blurred vision or increased irritation.

Child Dose

- **Pediatric Dosing**: The dosing for pediatric patients is similar to adults, with one or two drops applied to each affected eye as needed. However, the application should be supervised to ensure correct use, especially in young children who may not fully understand how to use eye drops properly. - **Safety and Efficacy**: Carboxymethylcellulose Sodium + Glycerine eye drops are generally safe for children, but the potential for misuse (e.g., excessive use) or contamination during administration requires caution. Safety and efficacy in infants and very young children should be assessed by a healthcare provider. - **Pediatric Monitoring**: In children, eye irritation or allergic reactions should be monitored, and treatment should be stopped if significant discomfort arises. Parents should also ensure the drops are stored properly to avoid accidental ingestion or misuse by young children.

Renal Dose

- **Renal Impairment**: Carboxymethylcellulose Sodium + Glycerine is not systemically absorbed in significant amounts, and thus, no dosage adjustments are necessary for patients with renal impairment. - **Monitoring Recommendations**: Although no renal-specific dosing adjustments are required, patients with severe renal impairment should still be monitored for any potential side effects related to excessive tear retention or irritation.

Administration

Information not available