PEG-INTRON 100mcg Price

Overview

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This medicine contains an important and useful components, as it consists of
Peginterferon alfa-2bis available in the market in concentration

Name

Peginterferon Alfa-2b

Precaution

Neuropsychiatric disorders, discontinue treatment with worsening or persistently severe signs/symptoms; chronically immunosuppressed and myelosuppresion; pulmonary disease; autoimmune disease; cardiovascular disease; DM; infectious disorders; ischaemic disorders; renal impairment; thyroid disorders; failed other alfa interferon therapy, received organ transplants, coinfected with HIV or hepatitis B, or received treatment for >1 yr. Elderly. Safety and efficacy not been established in children. Do not change brands of interferon without the concurrence of healthcare provider (product variability). Hazardous agent, handle and dispose appropriately. May affect ability to drive or operate machinery. Lactation: Unknown if excreted in human milk; decide whether to discontinue drug or breastfeeding

Indication

Chronic hepatitis C

Contra indication

Autoimmune hepatitis; decompensated liver disease; in combination with ribavirin in pregnant women.

Side Effect

>10% Headache (56%),Fatigue (52%),Injection site inflammation/reaction (47%),Depression (16-29%),Anxiety/emotional lability/irritability (28%),Nausea (26%),Insomnia (23%),Alopecia (22%),Fever (22%),Anorexia (20%),Diarrhea (18%),Abdominal pain (15%),Dizziness (12%),Impaired concentration (5-12%),Pain (12%),Pruritus (12%),Dry skin (11%),Weight loss (11%) 1-10% Pharyngitis (10%),Transient increase in transaminases (10%),Malaise (8%),Dermatitis (7%),Sinusitis (7%),Vomiting (7%),Dyspepsia (6%),Flushing (6%),Hepatomegaly (6%),Rash (6%),Hypertonia (5%),Hypothyroidism (5%),Injection site pain (2%),Taste perversion,Neutropenia,Thrombocytopenia <1% (Hepatitis C Trials) Colitis,Pancreatitis,Autoimmune thrombocytopenia,Blindess, thrombosis of retinal vein,Aggressive behavior,Depression,Homicidal thoughts, suicidal thoughts, suicide

Pregnancy Category ID

3

Mode of Action

Peginterferon alfa-2b are interferon proteins bound to polyethylene glycol (PEG) molecules resulting in higher and more prolonged serum interferon concentrations. It has a straight chain PEG; and requires reconstitution prior to use. It has antiviral, antiproliferative and immune-regulating activity. Interferons are activated when it interacts with cells through high affinity cell surface receptors. The effects of this activation include the induction of gene transcription, inhibition of cellular growth, alteration of cellular differentiation, interference with oncogene expression, alteration of cell surface antigen expression, increase in phagocytic activity of macrophages and augmentation of cytotoxicity of lymphocytes for target cells.

Interaction

Increased risk of haemolytic anemia, birth defects and/or foetal mortality, genotoxicity, mutagenicity, and may possibly be carcinogenic with ribavirin; decreases metabolism of theophylline; enhances adverse/toxic effects of zidovudine, decreases metabolism of zidovudine. Avoid ethanol in hepatitis C virus patients.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration