PEDIALYTE Price

Overview

Welcome to Dwaey, specifically on PEDIALYTE page.
This medicine contains an important and useful components, as it consists of
Citric acid, Dextrose, Potassium citrate, Sodium chloride, Sodium citrateis available in the market in concentration

Name

Paracetamol and Thiocolchicoside

Precaution

Before using a combination of **Paracetamol** (also known as **acetaminophen**) and **Thiocolchicoside**, it is crucial to consult with a healthcare provider, especially if you have any underlying health conditions. Some important precautions include: - **Liver Disease**: **Paracetamol** is metabolized by the liver, and excessive use can cause liver damage, especially in those with pre-existing liver conditions (e.g., **cirrhosis**, **hepatitis**). The recommended dosage should not be exceeded, and patients with liver disease should be closely monitored. - **Renal Disease**: Both drugs should be used with caution in patients with **renal impairment**, as **paracetamol** can affect kidney function when taken in large doses or for prolonged periods. - **Gastrointestinal Issues**: **Thiocolchicoside**, a muscle relaxant, can cause gastrointestinal upset, and it should be used cautiously in patients with a history of **ulcers** or **GI bleeding**. - **Pregnancy and Breastfeeding**: **Paracetamol** is generally considered safe in pregnancy and breastfeeding when used at recommended doses. However, **Thiocolchicoside** is contraindicated during pregnancy due to potential risks, especially in the early trimester. Always consult a healthcare provider before using this combination during pregnancy or breastfeeding. - **Drug Interactions**: This combination may interact with several medications, particularly **alcohol** (which can exacerbate liver toxicity) or other **hepatotoxic** drugs. Patients should avoid self-medication with other drugs that contain **acetaminophen** to prevent overdose.

Indication

The combination of **Paracetamol** and **Thiocolchicoside** is typically prescribed for conditions involving **pain** and **muscle spasm**, such as: - **Musculoskeletal Pain**: The combination helps manage pain and discomfort associated with conditions like **back pain**, **muscle spasms**, and other **musculoskeletal disorders**. - **Pain Relief with Muscle Relaxation**: The **paracetamol** component provides effective **analgesia**, while **thiocolchicoside**, a **muscle relaxant**, relieves muscle spasms and associated pain. - **Acute Injuries**: This combination is also indicated for the management of **acute soft tissue injuries**, where pain relief and muscle relaxation are needed. - **Conditions like Myositis**: In conditions like **myositis**, where inflammation of the muscles leads to pain and discomfort, this combination can provide therapeutic relief.

Contra indication

The combination of **Paracetamol and Thiocolchicoside** should not be used in certain conditions, including: - **Allergic Reactions**: Patients who have a known allergy or hypersensitivity to either **paracetamol** or **thiocolchicoside** should avoid using this medication. - **Severe Liver Disease**: **Paracetamol** is contraindicated in patients with **severe liver impairment** or **cirrhosis** due to its potential for liver toxicity. - **Severe Renal Impairment**: Patients with severe **renal failure** or significant renal dysfunction should avoid this combination, as **paracetamol** is cleared via the kidneys. - **Pregnancy (Thiocolchicoside)**: **Thiocolchicoside** is contraindicated in **pregnancy**, especially during the first trimester, due to potential risks to the developing fetus. - **Breastfeeding (Thiocolchicoside)**: This medication should be avoided in breastfeeding mothers, as **thiocolchicoside** can be excreted in breast milk and affect the infant.

Side Effect

The combination of **Paracetamol and Thiocolchicoside** may cause a range of side effects, some of which can be severe. These include: - **Paracetamol-related Side Effects**: - **Liver Damage**: High doses of **paracetamol** can lead to **hepatotoxicity**, liver failure, or even **acute liver failure**. Symptoms to watch for include jaundice, dark urine, and pain in the upper right side of the abdomen. - **Allergic Reactions**: Some individuals may experience allergic reactions, such as **rash**, **swelling**, or **itching**. In rare cases, severe reactions like **anaphylaxis** may occur. - **Gastrointestinal Upset**: **Paracetamol** may cause nausea, vomiting, or stomach discomfort in some individuals. - **Thiocolchicoside-related Side Effects**: - **Drowsiness and Sedation**: **Thiocolchicoside** can cause **drowsiness** and **sedation**, which may impair the ability to perform tasks requiring alertness (e.g., driving or operating machinery). - **Gastrointestinal Disturbances**: This drug may cause **nausea**, **vomiting**, or **diarrhea** in some individuals. - **Muscle Weakness**: As a muscle relaxant, **thiocolchicoside** may cause **muscle weakness** or a lack of coordination in some individuals. - **Hypotension**: **Thiocolchicoside** can occasionally lower blood pressure, leading to symptoms of **dizziness**, **lightheadedness**, or **fainting**. - **General Side Effects**: - **Headache** and **dizziness** are also reported side effects of this combination therapy. - **Rashes** or **skin reactions** can occur as allergic responses to either of the components. If any severe side effects occur, such as signs of **liver damage** (jaundice, dark urine) or **severe allergic reactions** (difficulty breathing, swelling), immediate medical attention is required.

Pregnancy Category ID

Information not available

Mode of Action

- **Paracetamol**: This drug works primarily by inhibiting the synthesis of **prostaglandins** in the brain. Prostaglandins are chemicals responsible for pain and inflammation. By reducing their production, **paracetamol** helps to alleviate pain and reduce fever. It does not have significant anti-inflammatory effects outside of the central nervous system. - **Thiocolchicoside**: It is a **muscle relaxant** that works by inhibiting the action of the **GABA receptors** and acting on the central nervous system to reduce muscle spasms. It has a **sedative effect** on the spinal cord, leading to a reduction in muscle tone and relieving muscle spasms, which are often seen in musculoskeletal conditions or injury.

Interaction

The **Paracetamol and Thiocolchicoside** combination can interact with several medications and substances, affecting its safety and efficacy: - **Alcohol**: Alcohol can increase the risk of **liver damage** when combined with **paracetamol**, as both substances are metabolized by the liver. Patients should avoid alcohol consumption while taking this medication. - **Anticoagulants (e.g., Warfarin)**: Long-term use of **paracetamol** can enhance the anticoagulant effect of **warfarin**, increasing the risk of bleeding. Close monitoring of blood clotting parameters is recommended. - **Hepatotoxic Drugs**: The combination should be used with caution in patients who are also taking other drugs that affect liver function, such as **phenytoin**, **carbamazepine**, or **rifampin**. - **CNS Depressants**: **Thiocolchicoside** may have additive effects when used with **central nervous system (CNS) depressants**, such as **benzodiazepines** or **opioids**, increasing the risk of sedation or respiratory depression. - **Diuretics and Antihypertensive Drugs**: **Thiocolchicoside** may interact with **antihypertensive** medications, potentially reducing their effectiveness in lowering blood pressure.

Pregnancy Category Note

Information not available

Adult Dose

The typical dosing for **Paracetamol and Thiocolchicoside** combination is: - **Paracetamol**: The usual dose for adults is **500 mg to 1000 mg** every 4 to 6 hours, with a maximum daily dose of **4000 mg**. For patients with liver impairment, the dose should be reduced, and it is essential not to exceed the daily limit. - **Thiocolchicoside**: The usual dose is **4 mg** two to three times daily. The duration of treatment is typically limited to **5-7 days** to minimize side effects like **sedation** or **muscle weakness**.

Child Dose

This combination is typically not recommended for children under the age of 12 due to potential risks and the need for age-specific dosing adjustments. In older children (12 years and above), **paracetamol** is dosed similarly to adults (up to **1000 mg** every 4-6 hours, not exceeding **4000 mg** per day), while **Thiocolchicoside** doses are typically around **2 mg to 4 mg** two to three times a day. Always consult a pediatric healthcare provider for specific dosing recommendations based on age and weight. As always, patients should consult with their healthcare provider before initiating this or any other combination therapy.

Renal Dose

Patients with **renal impairment** should use this combination cautiously, particularly **paracetamol**, which is metabolized and excreted via the kidneys. Dosage adjustments may be required for patients with **severe renal dysfunction**, and careful monitoring of kidney function is advised. **Thiocolchicoside** does not require specific dose adjustments based on renal function, but it should still be used with caution.

Administration

Information not available