PANVIRIN 400mg Price

Overview

Welcome to Dwaey, specifically on PANVIRIN 400mg page.
This medicine contains an important and useful components, as it consists of
Ribavirinis available in the market in concentration

Name

Ribavirin

Precaution

Patient w/ history of CHF, MI and/or previous or current arrhythmic disorders, ophthalmologic disorders, thyroid disorders, low CD4 count, substance use/abuse, COPD and asthma. Renal and hepatic impairment. Childn. Patient Counselling This drug may cause fatigue, somnolence or confusion, if affected, do not drive or operate machinery. Monitoring Parameters Monitor haematologic, cardiac, resp and ophth function; growth in paed patients; pregnancy tests mthly during and for 6 mth after discontinuation.

Indication

Chronic hepatitis C

Contra indication

Hypersensitivity. History of severe unstable cardiac disease, haemoglobinopathies, severe, debilitating medical conditions. CrCl <50 mL/min, severe hepatic impairment or decompensated liver cirrhosis. Male partners of pregnant women. Childn and adolescents w/ history of, or existing psychiatric disorders. Pregnancy and lactation.

Side Effect

>10% Fatigue (60-70%),Headache (63-66%),Hemolysis (61-64%),Myalgia (61-64%),Nausea (38-47%),Rigors (40-43%),Fever (32-41%),Insomnia (26-39%),Decreased Hgb (25-36%),Depression (23-36%),Hyperbilirubinemia (24-34%),Arthralgia (29-33%),Alopecia (27-32%),Irritability (23-32%),Musculoskeletal pain (20-28%),Rash (20-28%),Anorexia (21-27%),Dizziness (17-26%),Pruritus (13-21%),Flu-like syndrome (13-18%),Dyspnea (17-19%),Nasal congestion (13-18%),Dyspepsia (14-16%),Impaired concentration (10-14%),Thrombocytopenia (6-14%),Sinusitis (9-12%),Vomiting (9-12%),Emotional lability (7-12%),Decreased WBC; ANC <500 /cu.mm (5-11%) 1-10% Hemolytic anemia (~10%),Weakness (9-10%),Chest pain (5-9%),Taste perversion (6-8%),Nervousness (~5%)

Pregnancy Category ID

5

Mode of Action

Ribavirin is a synthetic nucleoside which has inhibitory action against respiratory syncytial virus, influenza virus and herpes simplex virus. The mechanism of action is not clear. It may act at several sites including cellular enzymes to interfere with viral nucleic acid synthesis. The mono- and triphosphate derivatives are known to be responsible for the antiviral action of the compound.

Interaction

May worsen neutropenia induced by interferon alfa. May increase risk of adverse effects when used with nucleoside reverse transcriptase inhibitors. Potentially Fatal: Risk of fatal hepatic failure, peripheral neuropathy and pancreatitis when used with didanosine. Increased risk of severe neutropenia and anaemia when used with zidovudine.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration