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Overview

Welcome to Dwaey, specifically on ORALITE page.
This medicine contains an important and useful components, as it consists of
Dextrose, Potassium chloride, Sodium chloride, Sodium citrateis available in the market in concentration

Name

Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride

Precaution

Before using **Poly (0-2-Hydroxyethyl) Starch 60g + Sodium Chloride**, it is essential for patients to consult their healthcare provider, especially in the following circumstances: - **Kidney Impairment**: Caution is advised in patients with **renal dysfunction** or **acute kidney injury**. The drug may exacerbate kidney problems, particularly with prolonged use or high doses. Frequent monitoring of kidney function is essential during therapy. - **Cardiovascular Conditions**: Patients with **heart failure**, **hypertension**, or those at risk of **fluid overload** should be carefully monitored. This combination of **hydroxyethyl starch** and **sodium chloride** may lead to excessive fluid retention and exacerbate these conditions. - **Electrolyte Imbalance**: Sodium chloride increases the risk of **hypernatremia** (high sodium levels), which can be dangerous. Monitoring of electrolyte levels is crucial, particularly in patients with conditions like **renal failure** or **hypertension**. - **Bleeding Disorders**: As hydroxyethyl starch can alter clotting functions, the drug should be avoided in patients with **disseminated intravascular coagulation (DIC)** or severe **bleeding disorders**. - **Allergic Reactions**: Patients with known **hypersensitivity** to **hydroxyethyl starch** or **sodium chloride** should avoid this treatment due to the risk of an **allergic reaction** that could include symptoms such as rash, swelling, or difficulty breathing.

Indication

**Poly (0-2-Hydroxyethyl) Starch 60g + Sodium Chloride** is commonly used in the following conditions: - **Plasma Volume Expansion**: It is used as a **volume expander** to help treat **hypovolemia** (low blood volume) resulting from trauma, surgery, or burns. The addition of sodium chloride helps restore fluid and electrolyte balance. - **Shock Management**: It is useful in **hypovolemic shock**, where it helps to maintain blood pressure and improve circulation by expanding the plasma volume and restoring fluid balance. - **Surgical and Postoperative Use**: In surgeries that result in significant blood loss, this combination can be used to restore the circulating blood volume and prevent complications like **hypotension** or **hypoperfusion**. - **Severe Dehydration**: This combination helps in treating severe dehydration, particularly in cases where traditional fluid replacement is insufficient or where electrolyte balance needs to be managed.

Contra indication

**Poly (0-2-Hydroxyethyl) Starch 60g + Sodium Chloride** is contraindicated in the following conditions: - **Severe Renal Impairment**: Contraindicated in patients with **acute kidney injury** or **chronic renal failure**, as the drug may worsen kidney function and increase the risk of fluid overload. - **Severe Bleeding Disorders**: Patients with **disseminated intravascular coagulation (DIC)** or **severe thrombocytopenia** should avoid this treatment, as hydroxyethyl starch can impair clotting and increase bleeding risk. - **Hypernatremia**: This drug is contraindicated in patients with **elevated sodium levels (hypernatremia)**, as the addition of sodium chloride could worsen the condition and lead to severe complications. - **Hypersensitivity**: Contraindicated in individuals with a known allergy to any component of the formulation, including **hydroxyethyl starch** or **sodium chloride**. - **Fluid Overload**: Should not be used in patients with conditions like **heart failure** where fluid retention may exacerbate symptoms and worsen the condition.

Side Effect

- **Common Side Effects**: - **Headache** - **Nausea or vomiting** - **Mild rash or itching** - **Elevated blood pressure** (due to fluid retention) - **Severe Side Effects**: - **Anaphylaxis**: A severe allergic reaction that can cause swelling of the throat, difficulty breathing, and a drop in blood pressure. - **Renal Failure**: Prolonged use or high doses can worsen **renal function**, potentially leading to **acute kidney injury**. - **Hypernatremia**: Elevated sodium levels can result in symptoms such as confusion, seizures, or a high risk of heart problems. - **Coagulation Abnormalities**: **Altered blood clotting** or an increased risk of **bleeding**, particularly in patients with existing bleeding disorders. - **Electrolyte Imbalances**: The addition of sodium chloride may lead to **hyperkalemia** (high potassium) or other imbalances in **sodium**, **chloride**, or **magnesium**.

Pregnancy Category ID

3

Mode of Action

**Poly (0-2-hydroxyethyl) starch** is a **colloidal volume expander** that works by increasing the **oncotic pressure** within the blood vessels. This draws fluid from the surrounding tissues into the bloodstream, thus expanding the **plasma volume** and improving circulation. The addition of **sodium chloride** helps restore **electrolyte balance** and supports proper fluid retention in the body. This combination is particularly useful in cases of **hypovolemic shock**, **blood loss**, or **fluid imbalances**, as it enhances the circulatory system’s ability to transport oxygen and nutrients.

Interaction

- **Anticoagulants**: Co-administration with **anticoagulants** such as **heparin** or **warfarin** may increase the risk of bleeding, as **Poly (0-2-hydroxyethyl) starch** can interfere with clotting. Careful monitoring of coagulation parameters is advised. - **Diuretics**: The use of **diuretics** in combination with this product may cause an imbalance in fluid and electrolytes, leading to problems like **dehydration** or **electrolyte disturbances**. - **ACE Inhibitors/Angiotensin II Receptor Blockers (ARBs)**: When combined with **ACE inhibitors** or **ARBs**, there could be an increased risk of **hyperkalemia** (high potassium levels) or changes in **renal function**, especially in patients with renal impairment. - **Corticosteroids**: Corticosteroid use may contribute to fluid retention, and when combined with **Poly (0-2-hydroxyethyl) starch**, could lead to **excessive fluid overload**.

Pregnancy Category Note

Information not available

Adult Dose

The recommended dose of **Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride** depends on the clinical condition and the patient’s response to treatment: - **For Volume Expansion**: A typical starting dose may range from **500 mL to 1,000 mL**, administered intravenously. This may be repeated as necessary based on the patient’s fluid requirements and vital signs. - **For Hypovolemic Shock**: Initial doses may start at **500 mL to 1,000 mL** intravenously, with additional doses given based on clinical response, such as improvement in blood pressure, heart rate, and urine output.

Child Dose

**Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride** is generally **not recommended** for pediatric use due to limited safety data. If its use is deemed necessary, it should be prescribed and monitored by a healthcare provider in a clinical setting. Pediatric doses, if administered, should be adjusted according to the child’s weight and the severity of the condition, with a focus on careful fluid balance and electrolyte monitoring. --- **Important Note**: As always, it is vital for patients to consult with a healthcare provider before using **Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride**, particularly in those with existing health conditions such as kidney disease, heart issues, or electrolyte imbalances. Close monitoring of **fluid balance**, **electrolytes**, and **renal function** is necessary to minimize risks associated with this treatment.

Renal Dose

In patients with **renal impairment**, the dosing of **Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride** should be adjusted. It is recommended to reduce the dose and monitor kidney function closely, as hydroxyethyl starch can exacerbate kidney problems, especially in patients with **acute kidney injury**. If renal function deteriorates, the use of this volume expander should be reassessed.

Administration

Information not available