OPTIZOLIN Price

Overview

Welcome to Dwaey, specifically on OPTIZOLIN page.
This medicine contains an important and useful components, as it consists of
Antazoline HCl, Tetrazoline HClis available in the market in concentration

Name

Antazoline Hydrochloride 0.05% + Tetryzoline Hydrochloride 0.04%

Precaution

- **Caution in cardiovascular diseases**: Both antazoline and tetryzoline are sympathomimetic drugs that can cause systemic vasoconstriction, which may increase blood pressure and heart rate. Use with caution in patients with hypertension, coronary artery disease, or other cardiovascular conditions. - **Use in pregnant and breastfeeding women**: Limited data on the safety of antazoline and tetryzoline during pregnancy and lactation. These medications should only be used if the potential benefit justifies the potential risk to the fetus or infant. - **Use in children**: This combination is generally not recommended for children under 2 years due to the risk of systemic absorption and adverse effects like increased heart rate or hypertension. - **Prolonged use**: Prolonged use of topical eye preparations may result in rebound redness or worsening of symptoms. Do not exceed the recommended duration of treatment without consulting a healthcare provider. - **Avoid use with other vasoconstrictor agents**: Combining with other decongestants or vasoconstrictors may increase the risk of systemic side effects, including hypertension and tachycardia. - **Caution in patients with narrow-angle glaucoma**: The use of sympathomimetics may increase intraocular pressure, so caution is required in patients with narrow-angle glaucoma or a predisposition to it.

Indication

- This combination is primarily indicated for the symptomatic relief of ocular redness and irritation caused by allergic conjunctivitis, such as itching, swelling, and watering of the eyes. - It is used to treat eye irritation caused by environmental factors such as smoke, dust, or pollen. - Antazoline and tetryzoline are also indicated for reducing eye redness in conditions like hay fever, pollen allergies, or seasonal conjunctivitis. - This combination is useful in managing eye symptoms associated with minor eye infections, following ocular surgeries, or due to contact lens irritation, under medical guidance. - It is often used as a short-term treatment to alleviate eye discomfort caused by environmental irritants.

Contra indication

- **Hypersensitivity**: Contraindicated in patients with known hypersensitivity to any of the components (antazoline or tetryzoline), or to other similar antihistamines or vasoconstrictors. - **Angle-closure glaucoma**: The vasoconstrictive properties of tetryzoline may increase intraocular pressure, which can be harmful in patients with angle-closure glaucoma. - **Systemic hypertension**: Contraindicated in patients with severe or uncontrolled hypertension due to the risk of vasoconstriction and elevation in blood pressure. - **Severe cardiovascular disorders**: Should not be used in patients with severe coronary artery disease, arrhythmias, or other significant cardiovascular conditions. - **Children under 2 years of age**: The safety and efficacy of this combination in children younger than 2 years have not been established, and there is a potential for adverse effects in this age group. - **Pregnancy and breastfeeding**: This combination should only be used if clearly needed and prescribed by a healthcare provider, as safety during pregnancy and lactation has not been well established.

Side Effect

- **Local irritation**: Burning, stinging, or discomfort in the eyes may occur immediately after administration. - **Rebound redness**: Prolonged use or overuse of the medication can lead to rebound redness or worsening of eye symptoms when the medication is stopped. - **Systemic effects**: Though rare, systemic absorption can lead to increased heart rate, hypertension, or other cardiovascular symptoms. - **Dry eyes**: The medication may cause dryness or a feeling of grittiness in the eyes, especially with long-term use. - **Pupillary dilation**: Some individuals may experience dilation of the pupils, resulting in light sensitivity (photophobia). - **Headache**: Some patients may experience headaches as a side effect, particularly with excessive use. - **Allergic reactions**: In rare cases, allergic reactions may occur, presenting as swelling, redness, or irritation in the eye area or surrounding skin. - **Glaucoma risk**: Prolonged use of sympathomimetic drugs like tetryzoline may increase intraocular pressure and could worsen glaucoma, particularly in susceptible individuals.

Pregnancy Category ID

3

Mode of Action

- **Antazoline hydrochloride**: An antihistamine that works by blocking histamine receptors (H1 receptors) in the body, reducing allergic symptoms such as itching, swelling, and redness in the eyes. - **Tetryzoline hydrochloride**: A sympathomimetic agent that acts as a vasoconstrictor, reducing redness in the eyes by constricting blood vessels in the conjunctiva and decreasing the amount of blood flow to the area. - **Combined action**: Together, antazoline and tetryzoline provide relief from both the allergic symptoms (histamine-driven) and the vascular congestion (caused by histamine-induced blood vessel dilation) in the eyes. The antihistamine component prevents further irritation, while the vasoconstrictor component quickly reduces redness and swelling. - This combination effectively targets the main symptoms of allergic conjunctivitis and environmental eye irritation, offering rapid relief from discomfort while reducing inflammation and redness.

Interaction

- **Other sympathomimetics**: Co-administration of other vasoconstrictor medications, including oral decongestants or nasal sprays, may increase the risk of systemic hypertension and tachycardia. - **Monoamine oxidase inhibitors (MAOIs)**: The combination of these eye drops with MAOIs (e.g., phenelzine, tranylcypromine) may enhance the hypertensive effects due to the combined sympathomimetic action. - **Beta-blockers**: When used together with beta-blockers, the vasoconstrictive effects of tetryzoline could be counteracted, potentially leading to more pronounced cardiovascular responses. - **Antihypertensive drugs**: Antihypertensive medications may have reduced efficacy when taken with vasoconstrictors like tetryzoline. - **Tricyclic antidepressants**: These drugs may potentiate the effects of sympathomimetic agents, leading to an increased risk of hypertension and tachycardia. - **Other antihistamines**: Combining with other antihistamine-containing eye drops or oral antihistamines could lead to increased drowsiness or a heightened risk of dry eyes and irritation. - **Corticosteroids**: Topical steroids may exacerbate glaucoma, especially when used with sympathomimetics, increasing intraocular pressure.

Pregnancy Category Note

Information not available

Adult Dose

- **For ocular redness and irritation**: One to two drops in the affected eye(s) up to 3 times per day, or as directed by a healthcare provider. - **Maximum dose**: Do not exceed the recommended dose of 3-4 applications per day. Prolonged use is not recommended without consultation with a healthcare provider due to the risk of rebound redness or tolerance. - **Duration of treatment**: Typically, treatment should not exceed 3-4 days. If symptoms persist beyond this period, a healthcare provider should be consulted for further evaluation.

Child Dose

- **For children 2-6 years of age**: One drop in the affected eye(s), up to 2 times a day, or as directed by a pediatrician. - **For children over 6 years of age**: The dosage may be similar to that for adults, typically one drop in the affected eye(s) up to 3 times a day, depending on the severity of symptoms and as advised by the healthcare provider. - **Children under 2 years**: Use in children under 2 years is contraindicated due to safety concerns and potential for serious side effects. - **Duration of treatment**: Treatment should not exceed 3 days in pediatric patients without seeking further medical advice.

Renal Dose

- **Renal impairment**: There is limited data on specific dose adjustments in patients with renal impairment, but given the systemic absorption potential of antazoline and tetryzoline, caution should be used. - **Severe renal impairment**: Use with caution in patients with significant renal dysfunction as drug clearance could be affected. Dosing frequency should be evaluated by a healthcare provider based on the individual’s renal function. - **Monitoring**: In patients with renal impairment, monitoring for any adverse systemic effects like increased heart rate or hypertension is recommended.

Administration

Information not available