DECAPEPTYL 3.75mg Price

Overview

Welcome to Dwaey, specifically on DECAPEPTYL 3.75mg page.
This medicine contains an important and useful components, as it consists of
Triptorelinis available in the market in concentration

Name

Triptorelin Acetate

Precaution

Before initiating **Triptorelin Acetate** therapy, it is essential for patients to consult their healthcare provider, especially if they have any of the following conditions: - **Pregnancy and Breastfeeding**: Triptorelin is contraindicated during pregnancy due to its potential to harm the fetus. It is also not recommended for breastfeeding mothers unless the benefits outweigh the risks. - **Bone Health**: Long-term use of Triptorelin can decrease bone mineral density, leading to an increased risk of **osteoporosis**. Bone health should be monitored regularly, and calcium and vitamin D supplements may be advised. - **Cardiovascular Concerns**: Patients with **heart disease** or risk factors for cardiovascular events should be monitored closely as Triptorelin may cause changes in blood pressure, leading to **hypertension** or **cardiovascular instability**. - **Existing Pituitary or Hypothalamic Disorders**: Patients with **pituitary tumors** or disorders affecting the **hypothalamic-pituitary-gonadal axis** should inform their doctor, as the drug may exacerbate these conditions. - **Psychiatric Disorders**: Triptorelin has been associated with mood changes, **depression**, and **anxiety**. Patients with a history of psychiatric disorders should be monitored closely.

Indication

Triptorelin Acetate is a **gonadotropin-releasing hormone (GnRH) agonist** that is used in various medical conditions: - **Prostate Cancer**: It is primarily used in the treatment of **advanced prostate cancer**. By inhibiting the secretion of **testosterone**, it helps slow down cancer progression. - **Endometriosis**: Triptorelin is used to manage **endometriosis**, as it reduces estrogen levels and helps alleviate pain associated with the condition. - **Uterine Fibroids**: It is used to shrink **uterine fibroids** before surgery, reducing bleeding and improving surgical outcomes. - **Central Precocious Puberty**: Triptorelin is used in children to treat **precocious puberty**, a condition where puberty begins too early. It helps delay the onset of puberty by inhibiting the release of sex hormones. - **In Vitro Fertilization (IVF)**: Triptorelin may be used as part of the treatment regimen to control ovarian stimulation and prevent premature ovulation during **IVF procedures**.

Contra indication

Triptorelin should not be used in the following conditions: - **Pregnancy**: Triptorelin is contraindicated during pregnancy due to the risk of fetal harm. It is a category X drug for pregnancy. - **Breastfeeding**: It is not recommended during breastfeeding as it may pass into breast milk. - **Hypersensitivity**: Patients with a known hypersensitivity to Triptorelin or other GnRH analogs should avoid using this drug. - **Women with Undiagnosed Vaginal Bleeding**: The drug should not be used in women with undiagnosed vaginal bleeding, as it may mask underlying pathologies. - **Pituitary Tumors**: Triptorelin is contraindicated in patients with **pituitary tumors** that could be affected by changes in hormone levels caused by the drug. - **Severe Osteoporosis**: As long-term use can decrease bone mineral density, patients with **severe osteoporosis** should not use this drug.

Side Effect

Like all medications, **Triptorelin Acetate** may cause side effects, which can range from mild to severe: - **Common Side Effects**: - **Hot flashes**: Due to the hormonal changes induced by Triptorelin, **hot flashes** are a frequent side effect. - **Headaches**: Patients may experience **headaches** or **migraines**. - **Mood Changes**: Feelings of **depression**, **irritability**, or **anxiety** may occur. - **Injection Site Reactions**: Patients may experience **pain**, **redness**, or **swelling** at the injection site. - **Decreased Libido**: Sexual desire may decrease in both men and women due to the suppression of sex hormones. - **Severe Side Effects**: - **Osteoporosis**: Prolonged use of Triptorelin can reduce bone mineral density, leading to **osteoporosis** or **bone fractures**. - **Cardiovascular Effects**: In rare cases, **arrhythmias**, **hypertension**, or changes in heart function may occur. - **Severe Mood Disturbances**: Some patients may experience severe mood changes, including depression or **suicidal thoughts**, particularly if they have a history of psychiatric conditions. - **Pituitary Apoplexy**: This rare but serious condition, which involves bleeding or damage to the pituitary gland, may occur due to a pre-existing pituitary tumor.

Pregnancy Category ID

5

Mode of Action

Triptorelin Acetate is a **GnRH agonist** that works by binding to the **GnRH receptors** in the pituitary gland. This results in an initial surge in the secretion of **luteinizing hormone (LH)** and **follicle-stimulating hormone (FSH)**, which then stimulates the production of **testosterone** in men and **estrogen** in women. However, with continued administration, Triptorelin causes a **desensitization** of the GnRH receptors, leading to a **long-term suppression** of LH and FSH secretion. This suppression significantly reduces the levels of **testosterone** in men and **estrogen** in women, effectively treating conditions such as **prostate cancer**, **endometriosis**, and **precocious puberty**.

Interaction

Several interactions may occur with **Triptorelin Acetate**, which could either reduce its effectiveness or enhance its side effects: - **Estrogen and Progesterone Therapy**: Concurrent use of **estrogen** or **progesterone** may interfere with the therapeutic effects of Triptorelin, particularly in the treatment of conditions like **endometriosis** or **fibroids**. - **Corticosteroids**: Triptorelin may increase the effectiveness of corticosteroids, and patients may require closer monitoring if these drugs are used together, particularly for conditions like **osteoporosis**. - **Insulin**: Triptorelin may affect **insulin** sensitivity in diabetic patients, potentially requiring an adjustment in their insulin dosage. - **Other GnRH Agonists/Antagonists**: Using Triptorelin together with other **GnRH agonists** or **antagonists** (like **leuprolide** or **buserelin**) may result in **excessive suppression** of gonadal function, leading to enhanced side effects. - **Cytochrome P450 Enzyme Inducers/ Inhibitors**: There may be interactions with drugs that affect liver enzyme systems, although significant clinical consequences are unlikely.

Pregnancy Category Note

Information not available

Adult Dose

The dosing of **Triptorelin Acetate** depends on the condition being treated: - **Prostate Cancer**: A common dose for prostate cancer is **3.75 mg every 4 weeks** via subcutaneous or intramuscular injection, or **11.25 mg every 12 weeks**. - **Endometriosis and Uterine Fibroids**: The typical dose is **3.75 mg every 4 weeks**. - **Precocious Puberty**: For children, the usual dose is **3.75 mg every 4 weeks**, though it may be adjusted based on the child’s response. - **In Vitro Fertilization (IVF)**: In IVF, Triptorelin is administered in a **single dose of 0.1 to 0.2 mg** before ovulation induction.

Child Dose

For the treatment of **central precocious puberty** in children, the recommended dose is typically **3.75 mg every 4 weeks**. For children undergoing IVF treatments or other hormonal therapy, dosages will be based on specific protocols set by the treating fertility or endocrinology specialist. Always consult a healthcare provider before beginning treatment with **Triptorelin Acetate** to ensure it is appropriate for the individual’s medical condition and needs.

Renal Dose

There is no need for dose adjustments for patients with **renal impairment**, as Triptorelin is not significantly excreted through the kidneys. However, careful monitoring is recommended in patients with severe renal dysfunction.

Administration

Information not available