NONPYROGENIC ACID CONCENTRATE FOR BICARBONATE HEMODIALYSIS (3-017-005) Price

Overview

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This medicine contains an important and useful components, as it consists of
Acetic acid, Calcium, Chloride, Glucose, Magnesium, Potassium, Sodiumis available in the market in concentration

Name

Iron Polymaltose + Vitamin B Complex + Zinc

Precaution

**Iron Polymaltose + Vitamin B Complex + Zinc** should be used with caution in certain populations. Iron supplementation (Iron Polymaltose) can lead to **iron toxicity**, especially in children, so it must be stored safely out of reach. In patients with **iron overload disorders** (such as **hemochromatosis** or **thalassemia**), this combination should be avoided due to the risk of exacerbating **iron accumulation**. Vitamin B Complex should be administered with care in individuals with a history of **renal impairment**, as high doses of certain B vitamins (like **B6**) may accumulate in the body and worsen kidney function. Caution is also advised for those with **gastrointestinal issues**, such as **ulcers** or **gastritis**, as iron can irritate the stomach lining, potentially leading to nausea, **stomach cramps**, or even **bleeding**. **Zinc** supplementation should be used carefully in those with **renal dysfunction**, as excessive zinc intake can affect **kidney function**. In pregnant women, this combination is generally safe, but the doses should align with the standard **prenatal recommendations**, avoiding excessive amounts that could lead to adverse effects like **iron overload** or **copper deficiency**. Monitoring for any gastrointestinal side effects and regular follow-up on zinc levels, especially in long-term use, is crucial. ---

Indication

**Iron Polymaltose + Vitamin B Complex + Zinc** is indicated for the **treatment and prevention of iron deficiency anemia**, especially in individuals with **iron** and **B-vitamin deficiencies**. It is often prescribed to address iron, B-vitamins, and zinc deficiencies, which are common in individuals with poor dietary intake, **malabsorption conditions**, or **pregnant women**. This combination aids in the formation of **red blood cells**, promotes **DNA synthesis**, and supports **immune function**. Additionally, it can be beneficial for individuals with **low hemoglobin levels** or **reduced red blood cell production**, particularly in conditions like **iron-deficiency anemia**, **megaloblastic anemia** (caused by folic acid or B12 deficiency), and **zinc deficiency**. **Zinc** supports **wound healing**, **growth**, and **immune function**. **Vitamin B Complex** (including **B1**, **B2**, **B6**, **B12**, **niacin**, and **folate**) is vital for **energy production**, **nervous system health**, and **cellular metabolism**. In some cases, this combination may be used as a preventative measure for people at high risk of these deficiencies, such as those with **poor diets**, **malnutrition**, or **chronic diseases** that impair nutrient absorption. ---

Contra indication

**Iron Polymaltose + Vitamin B Complex + Zinc** is contraindicated in individuals with **iron overload disorders** such as **hemochromatosis**, **thalassemia**, or **sideroblastic anemia**, where excessive iron accumulation can be harmful. It should not be used in patients with **hypersensitivity** to any of its components (iron, B vitamins, or zinc). Patients with **gastrointestinal disorders**, such as **gastritis**, **peptic ulcers**, or **GI bleeding**, should use this combination cautiously due to the potential for **gastric irritation** and worsening symptoms. Additionally, high doses of **B6** or **B12** can cause neurological issues in some individuals, so patients with **neurological conditions** should consult a healthcare provider before using this combination. In patients with **severe renal impairment**, the use of zinc should be monitored closely, as the kidneys play a key role in **zinc excretion**, and impaired function may lead to **zinc accumulation**. ---

Side Effect

The most common side effects of **Iron Polymaltose + Vitamin B Complex + Zinc** are related to **iron supplementation**: - **Gastrointestinal upset**: **Nausea**, **vomiting**, **constipation**, and **diarrhea** are common with iron supplements. **Dark stools** are also a frequent side effect and are harmless but can cause concern. - **Zinc toxicity**: Excessive zinc intake can lead to **nausea**, **vomiting**, **abdominal pain**, and **diarrhea**. Long-term high doses may cause **copper deficiency**, leading to **anemia** and **neurological issues**. - **B vitamin side effects**: While generally safe, high doses of **vitamin B6** can cause **neuropathy** and **nerve damage** when used long-term. **B12** supplementation is generally safe, but in rare cases, high doses can cause **skin reactions** or **mild diarrhea**. - **Iron toxicity**: In children, accidental **iron overdose** can cause **liver damage**, **gastrointestinal bleeding**, and in severe cases, **death**. In adults, excessive iron intake may also contribute to **iron overload** conditions like **hemochromatosis**, leading to organ damage. The side effects are usually dose-dependent, and most are mild and transient. If any serious side effects like **GI bleeding**, **fatigue**, or **neurological changes** occur, medical attention should be sought immediately. ---

Pregnancy Category ID

0

Mode of Action

- **Iron Polymaltose** is a form of iron that is easier on the stomach and is used to treat **iron deficiency anemia** by providing the body with **iron** necessary for **oxygen transport** in red blood cells. - **Vitamin B Complex** contains several essential vitamins (B1, B2, B6, B12, folic acid, and niacin) that play critical roles in **energy production**, **nerve function**, and **cellular metabolism**. These vitamins help maintain a healthy **nervous system**, **digestive system**, and **cardiovascular health**. - **Zinc** is involved in **immune function**, **protein synthesis**, and **cell division**. It also plays a key role in **wound healing** and the maintenance of **skin integrity**. Together, these nutrients help address deficiencies that can lead to **anemia**, **immune system issues**, and **neurological problems**. Iron helps improve **oxygen transport**, B vitamins support **metabolic health**, and zinc enhances **wound healing** and **immune defense**. ---

Interaction

**Iron Polymaltose + Vitamin B Complex + Zinc** has several interactions with other drugs and nutrients that should be taken into account: - **Iron and Antacids**: **Antacids**, **calcium**, and **magnesium** supplements can reduce iron absorption, so iron should be taken at least **2 hours apart** from these medications. - **Iron and Tetracycline Antibiotics**: **Iron** can decrease the absorption of **tetracyclines**, such as **doxycycline** or **minocycline**, leading to decreased effectiveness of these antibiotics. It is advised to take iron and antibiotics **at least 2 hours apart**. - **Vitamin B6 and Levodopa**: **Vitamin B6** can reduce the effectiveness of **levodopa**, a medication used in the treatment of **Parkinson’s disease**. Patients taking **levodopa** should consult their healthcare provider before using vitamin B complex supplements. - **Vitamin B12 and Metformin**: Long-term use of **metformin** may reduce **vitamin B12** absorption. Supplemental **B12** may be needed in some patients on **metformin therapy**. - **Zinc and Copper**: **Zinc** competes with **copper** for absorption in the intestine. Prolonged use of high-dose zinc may lead to **copper deficiency**, which can affect red blood cell production and cause **neurological problems**. Regular monitoring of **copper levels** may be necessary for long-term use. - **Vitamin C and Iron**: **Vitamin C** can enhance **iron absorption**, and this combination is often used together to improve iron bioavailability, especially in patients with **iron deficiency**. ---

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dose for **Iron Polymaltose + Vitamin B Complex + Zinc** is as follows: - **Iron Polymaltose**: 100-200 mg of iron daily, depending on the severity of the deficiency. - **Vitamin B Complex**: 1-2 tablets or as recommended by a healthcare provider, depending on the formulation and patient needs. - **Zinc**: 15-25 mg per day. Dosing adjustments should be made based on individual needs, clinical response, and the presence of any underlying health conditions. ---

Child Dose

For pediatric patients, the dose should be adjusted based on **age**, **weight**, and **clinical condition**. Typically: - **Iron Polymaltose**: 1-5 mg/kg/day of elemental iron, depending on the child's weight and degree of deficiency. - **Vitamin B Complex**: 200–400 mcg/day for children aged 1–18 years. - **Zinc**: 5-15 mg/day based on the child’s age and nutritional needs. Careful monitoring of **vital signs** and **nutrient levels** is crucial for pediatric patients to avoid the risk of side effects, particularly **gastrointestinal upset** or **zinc toxicity**. ---

Renal Dose

In patients with **renal impairment**, special care must be taken with the **zinc** component of this combination, as **zinc** may accumulate in the body and adversely affect **renal function**. **Renal dosing adjustments** may be necessary, particularly for those with severe kidney disease. Monitoring of **zinc levels** and **renal function** (including creatinine and eGFR) is crucial during treatment. If kidney function is significantly impaired, the use of this combination should be reconsidered or adjusted. ---

Administration

Information not available