NONPYROGENIC ACETATE HEMODIALYSIS CONCENTRATE F2 (3-002-010) Price

Overview

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Acetate, Calcium, Chloride, Glucose, Magnesium, Potassium, Sodiumis available in the market in concentration

Name

Econazole Nitrate 1% + Triamcinolone Acetonide 0.1 Topical

Precaution

Econazole nitrate 1% + Triamcinolone acetonide 0.1% is a combination topical treatment used for fungal infections and associated inflammation. When using this combination product, it is important to exercise caution in certain patient populations. The use of **topical corticosteroids**, such as triamcinolone acetonide, can suppress the **immune response** and **wound healing**, leading to an increased risk of infections, including fungal infections. As such, this combination product should be used with care in **immunocompromised** patients, those with **diabetes**, or patients with **chronic skin conditions**. For **pregnant women**, this product is generally classified under category **C** for pregnancy. Although minimal systemic absorption occurs, prolonged use of corticosteroids during pregnancy should be avoided unless absolutely necessary, as it can lead to potential fetal risk, including **low birth weight** and **intrauterine growth restriction**. **Lactating women** should also exercise caution and avoid application near the breast to prevent potential absorption of the drug by the infant. Topical steroids should be used cautiously in patients with **skin infections**, particularly if there is broken skin or ulcers. The use of this combination product may exacerbate fungal infections if used improperly, so continuous monitoring for signs of worsening fungal infection is advised.

Indication

Econazole nitrate 1% + Triamcinolone acetonide 0.1% topical combination is primarily indicated for the **treatment of superficial dermatological fungal infections** with associated inflammation. This combination is often used for conditions like **tinea corporis**, **tinea cruris**, **tinea pedis**, and **candidiasis**, where both an antifungal treatment (econazole nitrate) and anti-inflammatory (triamcinolone acetonide) effect are required. Econazole, a **azole antifungal**, works by inhibiting the synthesis of **ergosterol**, disrupting the fungal cell membrane, and ultimately killing the fungus. Triamcinolone, a **potent corticosteroid**, works by suppressing the **inflammatory response** and **reducing swelling**, itching, and redness associated with inflammatory skin conditions. **Off-label uses** may include treating conditions where inflammation accompanies a fungal infection, such as in certain **chronic dermatophyte infections**. However, its use in these cases should be based on clinical judgment, as prolonged corticosteroid use on fungal infections may lead to resistance or worsening of infection.

Contra indication

Econazole nitrate 1% + Triamcinolone acetonide 0.1% topical preparation is contraindicated in individuals who are **hypersensitive** to either of the components—econazole nitrate or triamcinolone acetonide. Patients with a history of **allergic reactions** to azole antifungals or corticosteroids should avoid using this medication. The product is also contraindicated for use on **active viral skin infections** (e.g., herpes simplex, chickenpox) or in areas with **tuberculosis** or **fungal infections** that have not yet been properly diagnosed or treated. Because of the corticosteroid component, it should not be used in areas with **open wounds** or **severe skin irritation**, as these conditions may increase absorption and risk of systemic side effects. Triamcinolone acetonide, a corticosteroid, is contraindicated in patients with a history of **systemic fungal infections** or those with untreated **bacterial** or **viral infections**.

Side Effect

Common side effects of **Econazole nitrate 1% + Triamcinolone acetonide 0.1% topical** combination include **skin irritation**, such as **burning**, **itching**, or **redness** at the site of application. These effects are typically mild and transient. Long-term use of **topical corticosteroids** like triamcinolone acetonide may lead to **skin thinning (atrophy)**, **striae (stretch marks)**, or **delayed wound healing**. Some users may experience **dryness** or **peeling** of the skin. Prolonged application to large areas of the body may increase the risk of **systemic absorption**, leading to potential side effects associated with corticosteroid use, including **Cushing’s syndrome**, **hypertension**, and **hyperglycemia**. Rare but serious side effects may include **allergic contact dermatitis**, **systemic side effects**, or **secondary bacterial or fungal infections** due to suppression of the immune response. If signs of **superinfection** (worsening infection or new infection) occur, the use of the product should be discontinued, and appropriate treatment should be initiated. If **eye irritation** or **vision changes** occur, especially if the product is used near the eyes, it should be discontinued, as corticosteroids can increase the risk of **cataracts** or **glaucoma** with prolonged use.

Pregnancy Category ID

3

Mode of Action

Econazole nitrate 1% + Triamcinolone acetonide 0.1% acts through a dual mechanism. **Econazole nitrate**, as an **azole antifungal**, inhibits the synthesis of **ergosterol**, which is crucial for the integrity of the fungal cell membrane. This results in disruption of the membrane, leading to leakage of cellular contents and ultimately fungal cell death. **Triamcinolone acetonide**, a **potent corticosteroid**, works by binding to glucocorticoid receptors in the skin. This binding leads to the **inhibition of phospholipase A2**, an enzyme involved in the synthesis of **prostaglandins** and **leukotrienes**, which are key mediators of the **inflammatory response**. This reduces **inflammation**, **itching**, and **swelling** associated with fungal infections. Together, the two components target both the fungal pathogen and the inflammatory response, making this combination particularly effective for treating **inflammatory fungal skin conditions**.

Interaction

Due to the local application of this combination product, **systemic drug interactions** are unlikely. However, some interactions may still occur when the product is used in combination with other **topical corticosteroids** or **antifungal treatments**. The combination of other topical corticosteroids can increase the risk of **skin atrophy** or systemic absorption, especially when used over large areas of skin or for prolonged periods. Caution should be taken when using this product with other **immunosuppressive agents**, as the corticosteroid component may further suppress the immune system. Concurrent use of **antifungal oral agents** like fluconazole or ketoconazole can theoretically enhance the antifungal effects, but there are no known direct interactions. It is recommended to **avoid using alcohol-based products** in the same area to reduce the risk of skin irritation. In general, **lifestyle factors**, such as smoking, do not significantly alter the pharmacodynamics of this topical combination, but they may influence the overall health of the skin and its response to treatment.

Pregnancy Category Note

Information not available

Adult Dose

For adults, **Econazole nitrate 1% + Triamcinolone acetonide 0.1%** is typically applied as a **thin layer to the affected area once or twice daily**. The duration of treatment varies depending on the severity and location of the infection, but it usually lasts between **2 to 4 weeks**. For **tinea infections**, therapy should be continued for **2-4 weeks**, even if symptoms improve, to ensure complete resolution of the infection. For **cutaneous candidiasis**, treatment may take up to **2 weeks**, depending on the response. Patients should apply the medication **sparingly**, ensuring the product covers the affected area without overuse, as prolonged use of corticosteroids can lead to side effects like skin thinning and increased absorption.

Child Dose

In pediatric patients, the use of **Econazole nitrate 1% + Triamcinolone acetonide 0.1%** should be done with caution, particularly in **children under 12 years**. While the dosing for children is generally similar to that for adults, **topical corticosteroids** should be used sparingly to reduce the risk of side effects such as **skin atrophy** and systemic absorption. The recommended dose for children is typically **a thin layer applied once or twice daily** to the affected area. Treatment should be limited to the smallest effective area to minimize potential side effects. Pediatric patients should be carefully monitored for **local irritation**, **delayed wound healing**, or signs of **systemic corticosteroid effects** such as weight gain or growth suppression. In summary, **Econazole nitrate 1% + Triamcinolone acetonide 0.1%** provides an effective treatment for **inflammatory fungal skin infections**, but care should be taken due to the potential side effects of corticosteroids and the risk of exacerbating fungal infections if not used appropriately. Monitoring for **local irritation**, **skin thinning**, and **systemic corticosteroid effects** is essential during therapy.

Renal Dose

Since **Econazole nitrate 1% + Triamcinolone acetonide 0.1%** is applied **topically**, there are no specific **renal dose adjustments** necessary. The systemic absorption of the medication is minimal. However, caution should be exercised in patients with **renal impairment**, as they may have an increased risk of systemic corticosteroid effects if the product is used excessively or on large surface areas of the body. In patients with **severe renal dysfunction**, topical corticosteroids should be used with great care, particularly when the drug is applied over broken or damaged skin.

Administration

Information not available