NEWEST Price

Overview

Welcome to Dwaey, specifically on NEWEST page.
This medicine contains an important and useful components, as it consists of
Polynucleotides , Sodium Hyaluronateis available in the market in concentration

Name

Neomycin Sulphate 0.35% + Polymixin B Sulphate 0.127% + Prednisolone 0.5% Eye prep

Precaution

Before using **Neomycin Sulphate 0.35% + Polymyxin B Sulphate 0.127% + Prednisolone 0.5% Eye Prep**, it is crucial to consult a healthcare provider to ensure proper usage. Key precautions include: - **Allergic reactions**: Patients should be aware of the potential for **allergic reactions** to any of the components, particularly **Neomycin**, which is a known allergen in some individuals. Symptoms of an allergic reaction include itching, swelling, and difficulty breathing. - **Glaucoma**: Prolonged use of **Prednisolone**, a corticosteroid, can increase the intraocular pressure, potentially leading to **glaucoma**. Patients with a history of glaucoma or increased intraocular pressure should be monitored closely during treatment. - **Corneal healing**: Prednisolone can delay corneal wound healing. Patients with any corneal injury, **ulcerations**, or **abrasions** should use this combination cautiously and under medical supervision. - **Infections**: Prolonged use of **steroid-containing eye drops** like **Prednisolone** can suppress the immune response, increasing the risk of eye infections, including **fungal** and **viral** infections. The medication should be used only for the prescribed duration to minimize this risk. - **Pregnancy and breastfeeding**: It is important for pregnant or breastfeeding women to discuss potential risks with their healthcare provider. The safety of **Prednisolone** during pregnancy is not well established, and the medication can be passed to the infant through breast milk. It should only be used if the benefits outweigh the risks. - **Contact lenses**: This medication is not recommended for use with **contact lenses**, especially if the lenses are not removed before application. This is due to the risk of **increased eye irritation**.

Indication

This combination eye preparation is typically prescribed for the treatment of eye conditions involving both **bacterial infections** and **inflammation**. Key indications include: - **Bacterial conjunctivitis**: This medication is often used for treating **bacterial eye infections**, such as **conjunctivitis** (pink eye), which may be caused by susceptible organisms. Neomycin and Polymyxin B are both antibiotics that target a broad range of bacteria, providing effective treatment. - **Ocular inflammation**: The **Prednisolone** in this combination is a corticosteroid that helps to reduce inflammation, redness, swelling, and irritation in the eye. It is often used for inflammatory conditions such as **iritis** (inflammation of the iris) or **uveitis** (inflammation of the eye’s uveal tract). - **Post-surgical inflammation**: After eye surgeries, such as cataract removal or corneal transplants, this eye preparation can be used to reduce inflammation and prevent infection. - **Allergic eye reactions**: This combination may also be indicated in treating eye conditions triggered by allergic reactions that cause inflammation and infection.

Contra indication

This medication should not be used in the following circumstances: - **Hypersensitivity**: The combination of **Neomycin**, **Polymyxin B**, or **Prednisolone** is contraindicated in patients with a known **allergy** or **hypersensitivity** to any of the components. Symptoms of an allergic reaction may include itching, swelling, rash, and difficulty breathing. - **Viral eye infections**: This eye preparation is contraindicated for use in patients with viral eye infections, such as **herpes simplex** keratitis. The corticosteroid component, **Prednisolone**, can exacerbate viral infections by suppressing the immune response, potentially leading to severe complications. - **Fungal eye infections**: If the eye infection is caused by **fungus**, the use of **Prednisolone** can worsen the infection by reducing the body’s ability to fight the infection, thus contraindicating its use in fungal eye conditions. - **Purulent eye discharge**: If the eye discharge is thick and **purulent**, indicating a severe infection, this medication may not be appropriate, and an alternate antibiotic treatment may be necessary. - **Open eye injuries or ulcers**: **Prednisolone** can delay the healing of corneal wounds or ulcers, so the combination should not be used in patients with **open eye injuries** or active **corneal ulcers** unless specifically advised by a healthcare provider.

Side Effect

Common side effects of this eye preparation include: - **Eye irritation**: Temporary **burning**, **stinging**, or **discomfort** in the eye after application is common, but it generally subsides quickly. - **Blurred vision**: Some patients may experience **temporary blurred vision** after applying the eye drops. This typically resolves within a few minutes after application. - **Increased intraocular pressure**: The **Prednisolone** in this preparation can lead to **elevated intraocular pressure**, which may result in **glaucoma** with prolonged use. Regular eye pressure monitoring is recommended. - **Allergic reactions**: As with any medication, allergic reactions can occur, including **rash**, **swelling**, **redness**, or **itchiness** in or around the eyes. Severe allergic reactions are rare but should be addressed immediately by discontinuing the medication. - **Eye infections**: Overuse or prolonged use can increase the risk of **secondary fungal or viral eye infections** due to the immunosuppressive effect of **Prednisolone**. Severe side effects to monitor for include: - **Vision changes**: Any significant changes in vision, such as **cloudiness** or **eye pain**, should be immediately reported to a healthcare provider. - **Signs of infection**: Symptoms like increased **redness**, **swelling**, or **discharge** may indicate an exacerbation or development of a new infection. - **Corneal damage**: Prolonged use of **Prednisolone** can lead to **corneal thinning** or **ulceration**, which may impair vision. Any persistent discomfort or eye injury should be promptly reported.

Pregnancy Category ID

3

Mode of Action

This eye preparation is a combination of an **antibiotic** and a **corticosteroid**, which work synergistically to treat both infection and inflammation: - **Neomycin** and **Polymyxin B** are **antibiotics** that target bacterial infections in the eye. Neomycin inhibits protein synthesis in bacteria by binding to bacterial ribosomes, leading to bacterial cell death. Polymyxin B disrupts the bacterial cell membrane, causing leakage of cellular contents and subsequent cell death. Together, these antibiotics provide a broad spectrum of activity against gram-positive and gram-negative bacteria. - **Prednisolone** is a **corticosteroid** that reduces inflammation by inhibiting **phospholipase A2**, which leads to a decrease in the production of **pro-inflammatory mediators** like **prostaglandins**. It also suppresses the immune response, which is beneficial in treating inflammatory eye conditions. However, prolonged use of corticosteroids can impair the body’s ability to combat infections, which is why careful monitoring is required.

Interaction

While **Neomycin Sulphate 0.35% + Polymyxin B Sulphate 0.127% + Prednisolone 0.5% Eye Prep** is a topical medication, potential interactions should still be considered: - **Other eye medications**: If the patient is using other topical eye drops or ointments, they should allow a **5-10 minute gap** between applications. Using multiple eye medications in close succession can reduce their effectiveness or increase the risk of irritation. - **Systemic corticosteroids**: When using oral **corticosteroids** in combination with topical **Prednisolone**, the risk of **systemic side effects**, including **glaucoma**, **hypertension**, and **immunosuppression**, may be heightened. Patients should monitor for adverse effects and consult with their healthcare provider if other corticosteroids are being used concurrently. - **Topical antibiotics**: Co-administration of **antibiotics** (oral or topical) with **Neomycin** and **Polymyxin B** may not result in any adverse effects, but careful monitoring is required, especially when dealing with resistant bacterial strains. - **Immunosuppressants**: The use of **Prednisolone** may interact with other **immunosuppressive** drugs, such as **methotrexate** or **azathioprine**, increasing the risk of infections or adverse effects related to immune suppression.

Pregnancy Category Note

Information not available

Adult Dose

The usual adult dose for **Neomycin Sulphate 0.35% + Polymyxin B Sulphate 0.127% + Prednisolone 0.5% Eye Prep** is: - **1-2 drops** in the affected eye(s) **2-4 times daily** or as prescribed by the healthcare provider. - For more severe infections or inflammation, the dosage may be increased to **every 1-2 hours** initially, tapering down as symptoms improve. Patients should follow their healthcare provider's instructions and not exceed the prescribed dosage.

Child Dose

For pediatric patients, the dosage is generally: - **1 drop** in the affected eye(s) **2-4 times daily**. The frequency and dosage may vary depending on the severity of the condition and the child’s response to the medication. - **Children under 2 years**: Should only use this medication under strict medical supervision due to the risk of potential side effects.

Renal Dose

Since **Neomycin Sulphate 0.35% + Polymyxin B Sulphate 0.127% + Prednisolone 0.5% Eye Prep** is used topically and is not significantly absorbed systemically, no renal dose adjustment is typically required. However, patients with **severe kidney disease** should use caution, as **Neomycin** is nephrotoxic when absorbed in larger amounts, although this is rare with topical use.

Administration

Information not available