NAVELBINE 50mg/5ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Vinorelbineis available in the market in concentration

Name

Vinorelbine

Precaution

Hepatic impairment. Compromised bone marrow reserve due to prior irradiation or chemotherapy; recovering marrow function from the effects of previous chemotherapy. Prior radiation therapy; past history or pre-existing neuropathy. CBC with differentials to be monitored prior to admin of subsequent doses. Delay subsequent doses, if neutrophil count < 2000 cells/mm3. Each admin to be followed by at least 250 ml of normal saline to flush the vein. Avoid extravasation. If extravasation occurs, stop infusion immediately, and flush the vein with normal saline solution; admin the remaining solution in another vein. Do not father a child during and up to six mth after treatment and females of childbearing potential to use effective method of contraception during treatment and three mth thereafter. When admin orally, capsules must be swallowed whole with water and not chewed or sucked. Lactation: not known if excreted in breast milk; do not nurse

Indication

Breast cancer, Ovarian cancer, Cervical cancer, Non-small cell lung cancer

Contra indication

Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.

Side Effect

>10% Leukopenia (92%),Granulocytopenia (90%),Anemia (83%),Elev AST (67%),Nausea (44%),Asthenia (36%),Constipation (35%),Fatigue (27%),Peripheral neuropathy (25%),Vomiting (20%),Anorexia (20%),Stomatitis (20%),Alopecia (12%) 1-10% Dyspnea (7%),Chest pain (5%),Rash (5%),SOB (3%),Hemorrhagic cystitis (1%),SIADH (1%)

Pregnancy Category ID

4

Mode of Action

Vinorelbine, a semisynthetic vinblastine derivative, binds to tubulin and inhibits microtubule formation. This disrupts the formation of the mitotic spindle thereby arresting the cell at metaphase.

Interaction

Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration