Active Substance: Naloxone HCl.
Overview
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This medicine contains an important and useful components, as it consists of
Naloxone HClis available in the market in concentration
Naloxone Hydrochloride
Patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated). Pregnancy and lactation. Lactation: Not known if distributed in milk; use caution
Opioid dependence, Opioid overdosage, Opioid-induced depression
Hypersensitivity.
Occur secondarily to reversal (withdrawal) of narcotic analgesia and sedation. Mental depression, apathy, inability to concentrate, sleepiness, irritability, anorexia, nausea, and vomiting in high oral doses during initial treatment of opiate addiction. Potentially Fatal: Severe cardiopulmonary effects (e.g. hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnoea, pulmonary oedema, cardiac arrest) in postoperative patients, most frequently in those with preexisting CV disease. Recurrence of respiratory depression in long-acting opioids.
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Naloxone is a pure opioid antagonist that acts competitively at opioid receptors.
Decreased effect of opioid analgesics. Potentially Fatal: Acute withdrawal reaction in physically dependent patients may occur with opioid analgesics. Severe cardiopulmonary effects may occur with cardiotoxic drugs.
Information not available