METHOTREXATE 1g/10ml Price

Overview

Welcome to Dwaey, specifically on METHOTREXATE 1g/10ml Injection page.
This medicine contains an important and useful components, as it consists of Methotrexate.
METHOTREXATE 1g/10ml is available in the market in concentration 100mg/ml and in the form of Injection.

DAVID BULL LABORATORIES is the producer of METHOTREXATE 1g/10ml and it is imported from AUSTRALIA, The most popular alternatives of METHOTREXATE 1g/10ml are listed downward .

Mode Of Action

Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

Indication

• Burkitt's lymphoma
• Choriocarcinoma
• Mycosis fungoides
• Crohn's disease
• Psoriasis
• Osteosarcoma
• Breast cancer
• lymphosarcoma
• Acute lymphoblastic leukaemia
• Rheumatoid arthritis

Precaution

Hepatic or renal impairment, bone marrow depression, elderly, neonates. Ulcerative disorders of the GI tract. Monitor haematological, renal and hepatic function, and GI toxicity regularly. Lactation: Drug excreted in breast milk; do not nurse

Side Effects

• >10% Arachnoiditis with intrathecal administration
• Subacute toxicity with intrathecal administration (paralysis of extremities
• cranial nerve palsy
• seizure or coma)
• Demyelinating encephalopathy with cranial irradiation or other systemic chemotherapy
• Reddening of skin
• Hyperuricemia
• Ulcerative stomatitis
• Glossitis
• Gingivitis
• Nausea and vomiting
• Diarrhea
• Anorexia
• Intestinal perforation
• Mucositis (dose-dependent)
• Leukopenia
• Thrombocytopenia
• Renal failure
• Azotemia
• Nephropathy
• Pharyngitis 1-10% Alopecia
• Photosensitivity
• Rash
• Abdominal distress
• Malaise
• Fatigue
• Chills
• fever
• Decreased resistance to infection
• Gastrointestinal hemorrhage
• Myelosuppression
• Disorders of lung
• interstitial pneumonia (acute
• chronic)
• Atrophy of liver
• cirrhosis
• hepatic fibrosis or necrosis
• elevated liver function tests
• hepatic failure Potentially Fatal: Pulmonary reactions (e.g. interstitial lung disease); neurotoxicity (e.g. leukoencephalopathy
• paresis
• demyelination) with intrathecal use; foetal deaths.

Contra indication

Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver disease, AIDS, pre-existing blood dyscrasias, pregnancy (in patients with psoriasis or rheumatoid arthritis), breast-feeding.

Pregnancy and lactation

Pregnancy category: X

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.