METHACIN 100mg price in UAE

Overview

Welcome to Dwaey, specifically on METHACIN 100mg Rectal Suppositories page.
This medicine contains an important and useful components, as it consists of Indomethacin.
METHACIN 100mg is available in the market in concentration 100mg/Suppository and in the form of Rectal Suppositories.

THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY is the producer of METHACIN 100mg and it is imported from JORDAN, The most popular alternatives of METHACIN 100mg are listed downward .

Mode Of Action

Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.

Indication

Rheumatoid arthritis
ankylosing spondylitis
and osteoarthritis (degenerative joint disease)
gout
acute non-articular rheumatism (bursitis
synovitis
tendinitis).

Precaution

Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation. Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)

Side Effects

>10% Transient renal insufficiency (40%)
Jaundice (<15%)
Elevated liver function test values (?15%)
Headache (12%) 1-10% Dizziness (3-9%)
Dyspepsia (3-9%)
Epigastric pain (3-9%)
Indigestion (3-9%)
Nausea (3-9%) Symptomatic upper GI ulcers
gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months). Abnormal pain/cramps/distress (<3%)
Constipation (1-3%)
Depression (1-3%)
Diarrhea (1-3%)
Fatigue (1-3%)
Somnolence (1-3%)
Tinnitus (1-3%)
Vertigo (1-3%) <1% Acute interstitial nephritis with hematuria/proteinuria
Acute respiratory distress
Agranulocytosis
Angioedema
Aplastic anemia
Asthma
Bone marrow depression
Congestive heart failure (CHF)
Hemolytic anemia
Leukopenia
Macular and morbilliform eruptions
Pulmonary edema
Thrombocytopenia
Thrombocytopenic purpura
Ulcerative stomatitis
Urticaria

Contra indication

Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin. Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to fatal GI haemorrhage.