LONQUEX¨ 6 mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Lipegfilgrastim is available in the market in concentration

Name

Tamsulosin + Dutasteride

Precaution

Before initiating treatment with **Tamsulosin + Dutasteride**, it is essential for patients to consult their healthcare provider to ensure the therapy is appropriate for their specific health condition. Both of these medications are commonly used in combination to treat benign prostatic hyperplasia (BPH), but several precautions need to be considered: - **Orthostatic Hypotension**: Tamsulosin, an alpha-1 adrenergic antagonist, can cause a sudden drop in blood pressure, especially when standing up (orthostatic hypotension). This may lead to dizziness, fainting, or falls. Patients should be advised to rise slowly from sitting or lying positions, particularly when starting therapy or increasing the dose. - **Liver Impairment**: Both Tamsulosin and Dutasteride are metabolized in the liver. Patients with hepatic impairment (liver problems) should use this combination cautiously, as the liver may not process the drugs as effectively, leading to increased concentrations and potential side effects. - **Prostate Cancer**: Both medications reduce the size of the prostate, which can mask the symptoms of prostate cancer. Men receiving this treatment should undergo regular screenings for prostate cancer, including prostate-specific antigen (PSA) testing, as this combination may impact PSA levels. - **Pregnancy and Female Contact**: Dutasteride is contraindicated in women who are pregnant or may become pregnant, as it may cause birth defects in a male fetus. Women should avoid handling Dutasteride capsules if broken, as the active ingredient may be absorbed through the skin. - **Kidney Impairment**: While Tamsulosin does not require dosage adjustments in mild to moderate kidney impairment, patients with severe renal dysfunction may need dose adjustments or monitoring. Dutasteride, however, should be used cautiously in patients with significant renal impairment. Patients must follow their healthcare provider's instructions and undergo routine monitoring while on this treatment.

Indication

The combination of **Tamsulosin + Dutasteride** is primarily indicated for the management of **benign prostatic hyperplasia (BPH)**, a condition in which the prostate gland becomes enlarged, causing urinary symptoms. This combination therapy works in different ways to treat BPH: - **Benign Prostatic Hyperplasia (BPH)**: This is the primary indication for the use of Tamsulosin and Dutasteride. Tamsulosin helps relax the muscles of the prostate and bladder neck, which improves urine flow and reduces the symptoms of BPH, such as difficulty urinating, frequent urination, or urgency. Dutasteride, a 5-alpha reductase inhibitor, reduces the size of the prostate by blocking the conversion of testosterone to dihydrotestosterone (DHT), which is a hormone responsible for prostate growth. - **Prevention of BPH Progression**: This combination is used to slow the progression of BPH in men, especially in those with moderate to severe symptoms. It helps prevent the need for surgical intervention or prostatectomy. Both medications address the underlying causes of BPH and help alleviate symptoms, improving quality of life for patients with this condition.

Contra indication

There are several contraindications to be aware of when using the **Tamsulosin + Dutasteride** combination: - **Hypersensitivity**: Individuals with a known hypersensitivity or allergy to Tamsulosin, Dutasteride, or any of the inactive ingredients in the formulation should not use this combination. - **Women of Childbearing Potential**: Due to the teratogenic effects of Dutasteride, this combination should not be used by pregnant women or those who may become pregnant. The drug can cause birth defects in male fetuses and can be absorbed through the skin if the capsule is broken. - **Children**: This combination is not approved for use in children, as there is insufficient data to support its safety and efficacy in pediatric populations. - **Severe Liver Disease**: Both Tamsulosin and Dutasteride are metabolized in the liver, so patients with severe liver disease should avoid using this combination due to the potential for altered drug metabolism and increased risk of side effects. - **Hypotension**: Tamsulosin can cause low blood pressure, particularly in individuals who are already prone to hypotension, such as those with certain cardiovascular conditions. It is contraindicated in such patients unless specifically prescribed and monitored by a healthcare provider. As always, individuals should consult with their healthcare provider to assess whether this treatment is appropriate for their specific health needs.

Side Effect

The combination of **Tamsulosin + Dutasteride** is generally well-tolerated, but like all medications, it can cause side effects. Common and severe side effects include: - **Common Side Effects**: - **Ejaculatory Dysfunction**: One of the most common side effects of Dutasteride is a reduction in semen volume or changes in ejaculatory function. This may include decreased libido or erectile dysfunction. - **Dizziness and Orthostatic Hypotension**: Tamsulosin can cause dizziness, especially when standing up quickly. This is due to the blood pressure-lowering effect and may lead to falls or fainting. - **Decreased Libido**: Both medications can cause a reduction in sexual drive or libido in some men. - **Fatigue**: Some patients report feeling unusually tired or fatigued while on this combination. - **Headache**: Headaches are a common side effect of Tamsulosin and may occur in some individuals. - **Serious Side Effects**: - **Allergic Reactions**: Although rare, some individuals may experience severe allergic reactions, including rash, swelling, or difficulty breathing. - **Breast Tenderness and Enlargement**: Dutasteride may cause breast tenderness, enlargement, or pain in some individuals. In rare cases, gynecomastia (male breast enlargement) may occur. - **Depression**: There have been reports of mood changes, including depression, associated with Dutasteride, though this is not a common side effect. - **Prostate Cancer**: Long-term use of Dutasteride may mask the symptoms of prostate cancer. Regular screenings are necessary to detect prostate cancer, as it may alter PSA (prostate-specific antigen) levels. Patients should contact their healthcare provider if they experience any of these side effects, particularly if they are severe or persistent.

Pregnancy Category ID

5

Mode of Action

The **Tamsulosin + Dutasteride** combination works through complementary mechanisms to address the symptoms and progression of **benign prostatic hyperplasia (BPH)**: - **Tamsulosin**: Tamsulosin is an alpha-1 adrenergic blocker that works by relaxing the smooth muscles in the prostate and bladder neck. This relaxation eases urine flow, reducing symptoms such as frequent urination, difficulty urinating, and urgency associated with BPH. - **Dutasteride**: Dutasteride is a **5-alpha reductase inhibitor**, which works by blocking the conversion of testosterone to dihydrotestosterone (DHT). DHT is a hormone that plays a major role in prostate growth. By reducing DHT levels, Dutasteride helps shrink the prostate over time, alleviating symptoms of BPH and reducing the risk of progression. The combined effect of these medications provides both short-term symptom relief and long-term prostate shrinkage, improving urinary function and quality of life for men with BPH.

Interaction

The **Tamsulosin + Dutasteride** combination may interact with several other medications and substances. Patients should inform their healthcare provider about all the medications they are taking, including over-the-counter drugs and supplements: - **Alpha-blockers**: When taken with other alpha-1 blockers, such as doxazosin, prazosin, or terazosin, the risk of hypotension (low blood pressure) and dizziness may be increased. Combining these medications should be done under close supervision by a healthcare provider. - **CYP3A4 Inhibitors**: Dutasteride is metabolized by the enzyme CYP3A4. Medications that inhibit this enzyme, such as ketoconazole, ritonavir, and certain antibiotics, can increase the concentration of Dutasteride in the blood, potentially leading to increased side effects. - **Blood Pressure Medications**: Tamsulosin, when used with other antihypertensive medications, can enhance the blood pressure-lowering effect, increasing the risk of orthostatic hypotension. Regular monitoring is recommended when combining these drugs. - **Warfarin**: Caution is advised when using Tamsulosin with warfarin or other anticoagulants, as there may be an increased risk of bleeding, though this interaction is not well established. Patients should also be cautious when using this combination with medications that may affect the liver or kidney function, as these organs play a crucial role in metabolizing these drugs.

Pregnancy Category Note

Information not available

Adult Dose

The recommended **adult dose** of **Tamsulosin + Dutasteride** typically involves a single daily dose: - **Tamsulosin**: The usual starting dose is **0.4 mg** once daily, taken approximately 30 minutes after the same meal each day to minimize the risk of side effects like dizziness. - **Dutasteride**: The usual dose is **0.5 mg** once daily, taken at the same time each day. These medications are often taken together as part of a combined formulation. Dosing may be adjusted depending on the patient's response to treatment and any side effects experienced. It's important to follow the healthcare provider's instructions and not adjust the dose without consultation.

Child Dose

This combination of **Tamsulosin + Dutasteride** is **not approved for use in children**. There is insufficient data on the safety and efficacy of these medications in pediatric populations. The treatment is specifically indicated for adult men with BPH and should not be prescribed to children under any circumstances. Patients should always consult their healthcare provider for the appropriate treatment options based on their specific health conditions.

Renal Dose

For patients with **renal impairment** (kidney issues), the dosage of **Tamsulosin** may require adjustment, particularly in those with severe kidney dysfunction (creatinine clearance <10 mL/min). Tamsulosin should be used with caution in these individuals, and the starting dose may be reduced to **0.4 mg** once daily. **Dutasteride**, however, does not require any specific dose adjustment for renal impairment, as it is not significantly excreted by the kidneys. Nonetheless, patients with severe renal impairment should still be monitored for any adverse effects or drug interactions.

Administration

Information not available