Active Substance: Etodolac.
Overview
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This medicine contains an important and useful components, as it consists of
Etodolacis available in the market in concentration
Etodolac
CHF, dehydration, impaired renal, hepatic function, history of GI disease. Elderly, patients receiving anticoagulant. Lactation: Unknown whether drug is excreted in breast milk; not recommended
Rheumatoid arthritis, Pain, Osetoarthritis
Peptic ulcer, hypersensitivity to etodolac/NSAIDs. Childn; pregnancy (3rd trimester) and lactation.
1-10% Dyspepsia (10%),Dizziness (3-9%),Nervousness (1-3%),Pruritus (1-3%),Blurred vision (1-3%),Depression (1-3%),Chills/fever (1-3%) >1% Asthenia, malaise,Blurred vision,Bronchospasm,Dysuria, urinary frequency,Edema,Melena,Rash,Tinnitus Potentially Fatal: Acute renal failure; blood disorder; nephrotoxicity; angioedema, arrhythmia, bone marrow suppression, CHF, dyspnoea, erythema multiforme, exfoliative dermatitis, hepatitis, hypertension, peripheral neuropathy, Stevens-Johnson syndrome, syncope, tachycardia, toxic amblyopia, toxic epidermal necrolysis, urticaria.
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Etodolac is an NSAID derived from pyrano-indoleacetic acid, inhibits cyclooxygenase 2 (COX-2) resulting in decreased prostaglandin precursor formation.
Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin. Effect may be reduced with aspirin. Reduced effect of some diuretics and ?-blockers. Alcohol enhances gastric mucosal irritation.
Pregnancy category: C; D in 3rd trimester or near delivery. Avoid in late pregnancy (may cause premature closure of ductus arteriosus)