KETALAR 10mg/ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Ketamine HClis available in the market in concentration

Name

Ketamine

Precaution

Minimise verbal and tactile stimulation during recovery period. Chronic alcoholic and alcohol-intoxicated patients. Preanaesthetic elevated CSF pressure. Dependence and tolerance may develop. May impair ability to drive or operate machinery. Monitor cardiac function in patients with hypertension or cardiac decompensation. Pregnancy and lactation.

Indication

Induction of anesthesia.

Contra indication

Hypertension, history of cerebrovascular accident. Eye injury, raised ocular and intracranial pressure. Psychotic disorders.

Side Effect

>10% Emergence rxns (Emergence reactions e.g. vivid dreams, hallucinations, confusion, irrational behaviour) HTN,Increased cardiac output,Increased ICP,Tachycardia,Tonic-clonic movements,Visual hallucinations,Vivid dreams 1-10% Bradycardia,Diplopia,Hypotension,Increased IOP,Injection-site pain,Nystagmus <1% Anaphylaxis,Cardiac arrhythmia,Depressed cough reflex,Fasciculations,Hypersalivation,Increased IOP,Increased metabolic rate,Hypertonia,Laryngospasm,Respiratory depression or apnea with large doses or rapid infusions

Pregnancy Category ID

2

Mode of Action

Ketamine is a noncompetitive N-methyl-D-aspartate receptor antagonist that blocks glutamate. It has a direct action on the cortex and limbic system. It produces a cataleptic-like state wherein the patient is withdrawn from the surrounding environment.

Interaction

Prolonged recovery time w/ barbiturates or narcotics. May potentiate neuromuscular blocking effects of atracurium and tubocurarine including resp depression w/ apnoea. May increase risk of bradycardia, hypotension or decreased cardiac output w/ halogenated anaesth. May potentiate CNS depression and risk of resp depression w/ CNS depressants (e.g. phenothiazines, sedating H1-blockers, skeletal muscle relaxants). May antagonise hypnotic effect of thiopental. May increase risk of HTN w/ thyroid hormones. May increase risk of hypotension w/ antihypertensive agents. Reduction in seizure threshold resulting in unpredictable extensor-type seizures when given concurrently w/ theophylline.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration