KEPROGEL 2.5% w/w Price

Overview

Welcome to Dwaey, specifically on KEPROGEL 2.5% w/w page.
This medicine contains an important and useful components, as it consists of
Ketoprofenis available in the market in concentration

Name

Ketoprofen

Precaution

History of GI disease (e.g. bleeding or ulcer). Hypertensive patients; renal or hepatic impairment. Pregnancy, lactation, elderly. Monitoring Parameters Close monitoring of BP during initiation and throughout the therapy. Complete blood cell count, chemistry profile, liver and renal function test performed periodically for patients receiving long-term ketoprofen therapy.

Indication

Rheumatic disorders, Pain and inflammation, Musculoskeletal and joint disorders,

Contra indication

For all routes: Hypersensitivity to aspirin or other NSAIDs or those suffering from asthma, angioedema, urticaria or rhinitis. Active GI disease (e.g. bleeding or ulcer). Severe heart failure, and renal insufficiency. Treatment of perioperative pain in the setting CABG surgery. Rectal: Patients w/ history of proctitis or haemorrhoids.

Side Effect

>10% Increased liver function test (up to 15%),Dyspepsia (12%) 1-10% Dizziness (3-9%),Headache (3-9%),Impaired renal function disorder (3-9%),Upper GI ulcers, 3-6 mth treatment; 2-4%,1 yo treatment),Nausea (>3%),Diarrhea (>3%),Abdominal pain (>3%),Constipation (>3%),Flatulence (>3%),Rash (1-3%),Stomatitis (1-3%),Insomnia (1-3%),Malaise (1-3%),Depression (1-3%),Ketoprofen-induced peptic ulcer, GI bleeding (>2% in long-term studies);,Peripheral edema (2%),Bronchospasm (<2%),Myocardial infarction (<2%) <1% Congestive heart failure (<1%),Hypertension (<1%),Scaling eczema, Stevens-Johnson syndrome (<0.1%),Gastrointestinal hemorrhage (<1%),Gastrointestinal perforation (<1%),Melena (<1%),Agranulocytosis (<1%),Anemia (<1%),Thrombocytopenia (<1%),Hepatitis (<1%),Anaphylactoid reaction (<1%),Immune hypersensitivity reaction,Cerebrovascular accident,Interstitial nephritis (<1%),Renal failure (<1%) Potentially Fatal: Anaphylaxis, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Pregnancy Category ID

2

Mode of Action

Ketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.

Interaction

Increases plasma concentrations of lithium and methotrexate. Reduces effects of antihypertensives (e.g. ACE inhibitors, angiotensin II receptor antagonists). Increased risk of GI bleeding w/ warfarin. Decreased protein binding of ketoprofen and increased risk for serious GI events w/ aspirin and other NSAIDs. Increased risk of developing renal failure w/ diuretics. Increased risk of GI bleeding and ulceration w/ corticosteroids. Increased plasma levels w/ probenecid. Salicylate reduces conjugation and renal elimination of ketoprofen.

Pregnancy Category Note

Pregnancy Category: B; D in 3rd trimester or near delivery.

Adult Dose

Child Dose

Renal Dose

Administration