JANUVIA 50 Price

Overview

Welcome to Dwaey, specifically on JANUVIA 50 Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Sitagliptin (as monohydrate phosphate).
JANUVIA 50 is available in the market in concentration 50mg/Tablet and in the form of Tablets/Film-coated.

MERCK SHARP & DOHME LIMITED is the producer of JANUVIA 50 and it is imported from UK, The most popular alternatives of JANUVIA 50 are listed downward .

Mode Of Action

Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV), resulting in prolonged active incretin levels. Incretin hormones increases insulin synthesis and release from pancreatic ?-cells and reduces glucagon secretion from pancreatic ?-cells. Reduced glucagon secretion leads to decreased hepatic glucose production.

Indication

• Type 2 diabetes mellitus

Precaution

Patient w/ type 1 diabetes, history of angioedema. Not intended for the treatment of diabetic ketoacidosis. Moderate and severe renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor glycosylated Hb (HbA1c), serum glucose. Assess renal function prior to initiation of therapy and periodically thereafter. Lactation: Not known whether excreted in breast milk: use caution

Side Effects

• 1-10% Nasopharyngitis (5%)
• Diarrhea (4%)
• Headache (3.6%)
• Constipation (3%)
• Peripheral edema (2%)
• Nausea (2%)
• Pharyngitis (1%)
• Osteoarthritis (1%)
• URI (1%) <1% Hypersensitivity reactions such as anaphylaxis
• angioedema
• rash
• urticaria
• cutaneous vasculitis
• and exfoliative skin conditions (including Stevens-Johnson syndrome) Hepatic enzyme elevations
• Acute pancreatitis
• including fatal and nonfatal hemorrhagic and necrotizing pancreatitis.Constipation.Vomiting.Worsening renal function
• including acute renal failure (sometimes requiring dialysis)
• Severe and disabling arthralgia
• Myalgia
• Pain in extremity
• Back pain

Contra indication

Hypersensitivity reactions such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome can occur. Type 1 diabetes. Diabetic ketoacidosis.

Pregnancy and lactation

Pregnancy category: B

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.