JANUMET XR 50mg/500mg price in UAE

Overview

Welcome to Dwaey, specifically on JANUMET XR 50mg/500mg Tablets/Extended Release page.
This medicine contains an important and useful components, as it consists of Sitagliptin (as phosphate monohydrate), Metformin HCl.
JANUMET XR 50mg/500mg is available in the market in concentration 50mg, 500mg/Tablet and in the form of Tablets/Extended Release.

MERCK SHARP & DOHME CORPORATION is the producer of JANUMET XR 50mg/500mg and it is imported from USA, The most popular alternatives of JANUMET XR 50mg/500mg are listed downward .

Mode Of Action

Sitagliptin: Dipeptidyl peptidase 4 (DPP-4) inhibitor, thereby increasing and prolonging incretin hormone activity which are inactivated by DPP-4 enzyme. Incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion pancreatic alpha cells. Metformin: Biguanide; acts by decreasing endogenous hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; improves glucose tolerance and lowers both basal and postprandial plasma glucose .

Indication

Type 2 DM

Precaution

Not for use in type 1 DM or treatment of ketoacidosis. Discontinue use if pancreatitis is suspected. Renal & hepatic impairment. Sulfonylurea- or insulin-induced hypoglycemia, risk of lactic acidosis, hypoxic states, surgical procedures, alcohol intake, decreased vit B12 absorption, loss of glycemic control. Pregnancy. Elderly. Childn <18 yr. Lactation: not known if crosses into breast milk, use caution Pregnancy Categories

Side Effects

1-10% Abdominal pain (2.2%)
Diarrhea (2.4%)
Hypoglycemia (2.1%)
Nausea (1.3%)
Vomiting (1.1%) Frequency Not Defined Exfoliative disorder of skin of scalp
Stevens-Johnson syndrome
Lactic acidosis (rare )
Anaphylaxis/hypersensitivity reaction
Rhabdomyolysis
Acute renal failure
Angioedema

Contra indication

Renal dysfunction, e.g., serum creatinine >1.5 mg/dL [males], >1.4 mg/dL [females] or abnormal creatinine clearance. Metabolic acidosis, including diabetic ketoacidosis. History of a serious hypersensitivity reaction (e.g., anaphylaxis or angioedema) to Sitagliptin + Metformin or to one of its components.

Pregnancy and lactation

Pregnancy category: B

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Interaction

Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid may exacerbate loss of glycaemic control. ACE inhibitors may reduce fasting blood glucose concentrations. May increase serum level w/ cimetidine. Potentially Fatal: Concurrent use w/ iodinated contrast agents may increase the risk of metformin-induced lactic acidosis.