INFLUVAC Tetra 15mcg/0.5 ml Price

Overview

Welcome to Dwaey, specifically on INFLUVAC Tetra 15mcg/0.5 ml page.
This medicine contains an important and useful components, as it consists of
1. A/Guangdong-Maonan/SWL1536/2019 (H1N1)pdm09-like strain(A/Guangdong-Maonan/SWL1536/2019, CNIC-1909) 2. A/Hong Kong/2671/2019 (H3N2)-like strain (A/Hong Kong/2671/2019, IVR-208) - 3. B/Washington/02/2019-like strain (B/Washington/02/2019, wild type)is available in the market in concentration

Name

Elemental Iron + Folic Acid + Vitamin C + Zinc

Precaution

The combination of **Elemental Iron**, **Folic Acid**, **Vitamin C**, and **Zinc** is commonly used to address deficiencies in iron, folate, vitamin C, and zinc, and to support overall health, especially in conditions such as **iron deficiency anemia** or **nutritional deficiencies**. However, caution must be taken in specific populations or situations: - **Iron supplementation** is contraindicated in individuals with **iron overload** conditions like **hemochromatosis** or **thalassemia**, as excessive iron can lead to toxic accumulation in organs such as the **liver**, **heart**, and **pancreas**, causing significant damage. - High doses of **Vitamin C** can lead to **gastrointestinal disturbances** such as **nausea**, **cramps**, and **diarrhea**, particularly in individuals with sensitive stomachs. Patients with a history of **kidney stones** or **renal impairment** should be cautious, as excessive vitamin C can increase the risk of **kidney stone formation**. - **Zinc** should be used with caution in patients with **renal impairment**, as the kidneys are involved in zinc metabolism. Overuse or prolonged supplementation can lead to **zinc toxicity**, interfering with **copper absorption** and causing **neurological damage**. - **Folic acid** supplementation can mask symptoms of **vitamin B12 deficiency**, which is important to note in populations who are at risk of B12 deficiency, such as those with **pernicious anemia** or **vegetarian diets**. - Monitoring for **iron toxicity** is important, especially in children, as iron overdose can cause **gastrointestinal distress**, **liver damage**, and in severe cases, **shock** or **death**.

Indication

This combination is primarily indicated for the **prevention and treatment of iron deficiency anemia**, a condition where there is a lack of sufficient iron in the body, leading to reduced hemoglobin production and impaired oxygen transport. The inclusion of **folic acid** helps address **megaloblastic anemia**, which occurs due to folate deficiency, and is especially important during **pregnancy** to prevent neural tube defects in the fetus. **Vitamin C** is included to enhance the absorption of **iron**, as it reduces iron to a more absorbable form in the gastrointestinal tract. This combination is also beneficial for **people with inadequate dietary intake** or those at risk of **nutrient deficiencies**, such as individuals with **poor diet**, **malabsorption syndromes**, or those undergoing **chronic blood loss**. **Zinc** is involved in **immune function**, **protein synthesis**, and **cell division**, and its inclusion helps address **zinc deficiencies** that may lead to impaired immune function, poor wound healing, and other metabolic disturbances. - **Off-label uses** might include the management of **wound healing**, **immune system support**, and in certain cases of **chronic disease states** where these micronutrients are depleted, such as in **chronic kidney disease** or **malabsorption syndromes**.

Contra indication

This combination should not be used in certain conditions: - **Iron overload conditions**, such as **hemochromatosis**, **thalassemia**, or **sideroblastic anemia**, where iron supplementation could exacerbate iron accumulation and lead to organ damage, especially in the **liver**, **heart**, and **pancreas**. - **Known hypersensitivity** to any component, including **iron**, **folic acid**, **vitamin C**, or **zinc**. - **Vitamin C toxicity**: Patients with a history of **kidney stones** or **renal dysfunction** should avoid high doses of **Vitamin C**, as it can increase the risk of **oxalate kidney stones**. - **Vitamin B12 deficiency**: Folic acid supplementation should be used cautiously in patients with a **vitamin B12 deficiency**, as it can mask the symptoms of **pernicious anemia** and delay the diagnosis of B12 deficiency, leading to potential neurological damage. - In patients with **severe gastrointestinal diseases**, including **gastritis** or **ulcerative conditions**, care should be taken as **iron** supplements can exacerbate these conditions and cause discomfort or gastrointestinal bleeding.

Side Effect

The side effects of **Elemental Iron + Folic Acid + Vitamin C + Zinc** are generally mild but can vary based on the individual's sensitivity and dosage: - **Iron** supplementation can cause common side effects such as **nausea**, **vomiting**, **constipation**, and **dark stools**. These effects are typically dose-dependent and may be minimized by taking iron with food, though food can reduce absorption. - **Vitamin C** at high doses can lead to **gastrointestinal upset**, including **diarrhea**, **cramps**, and **gastritis**. High doses should be avoided in individuals with a history of **kidney stones** or **gastric issues**. - **Zinc** supplementation can cause **nausea**, **vomiting**, and **abdominal pain**, particularly when taken in excess. Chronic high doses of zinc may cause **copper deficiency** and neurological symptoms. - **Folic acid** is generally well-tolerated but may cause **insomnia**, **irritability**, or **mild gastrointestinal discomfort**. High doses can mask symptoms of **vitamin B12 deficiency**, which is an important consideration for older adults or those with poor diet quality. - **Iron toxicity** is a serious concern, especially in **children**, leading to **gastrointestinal bleeding**, **liver damage**, and in severe cases, **shock** or **death**. Therefore, it’s critical to store iron-containing supplements out of reach of children. To minimize these side effects, it is recommended to **start with a lower dose** and **gradually increase** as tolerated, and to take supplements with food if gastrointestinal discomfort occurs.

Pregnancy Category ID

0

Mode of Action

This combination works synergistically to treat and prevent various nutritional deficiencies: - **Elemental Iron** is critical for the formation of **hemoglobin** in red blood cells, which carries oxygen throughout the body. The body’s ability to produce red blood cells depends on an adequate supply of iron. - **Folic Acid (Vitamin B9)** is vital for **DNA synthesis**, particularly in **red blood cell formation**, and helps prevent **megaloblastic anemia**. It also supports fetal development during pregnancy, particularly in the formation of the neural tube. - **Vitamin C** is a powerful antioxidant that **enhances iron absorption** in the gut. It helps **reduce iron to its ferrous form**, making it easier for the body to absorb and utilize. Vitamin C also contributes to **collagen formation**, supporting tissue repair and immunity. - **Zinc** plays a central role in **immune function**, **cell growth**, **protein synthesis**, and **wound healing**. It also supports **DNA synthesis** and is necessary for proper enzymatic function in the body. The **pharmacokinetics** of these nutrients vary: **Iron** is absorbed in the small intestine and is often better absorbed when taken on an empty stomach or with **vitamin C**. **Folic acid** is absorbed in the small intestine and is stored primarily in the liver. **Zinc** is absorbed in the small intestine, but its absorption can be impaired by other minerals. **Vitamin C** is well absorbed and widely distributed in the body, with excess being excreted in the urine.

Interaction

Several drug-drug and nutrient interactions should be considered when taking **Elemental Iron + Folic Acid + Vitamin C + Zinc**: - **Iron** interacts with **antacids**, **proton pump inhibitors (PPIs)**, and certain **calcium supplements**, which may reduce its absorption. Iron should be taken **separately** from these medications, ideally **2 hours before or after** their administration. - **Vitamin C** enhances the absorption of **non-heme iron** (the type of iron found in plant-based foods and supplements), but this could be problematic for individuals who do not need additional iron or have **iron overload** conditions. - **Folic acid** may interact with **methotrexate** or other **chemotherapy agents**, as it may affect their effectiveness by competing for the same metabolic pathways. - **Zinc** competes with **copper** for absorption, so **excessive zinc supplementation** over time could lead to **copper deficiency**, affecting neurological function. It is also important to note that zinc may **interfere with the absorption** of other minerals, such as **iron** and **calcium**. - **Tetracyclines** and **fluoroquinolones**: **Iron** and **zinc** can reduce the absorption of these antibiotics, diminishing their effectiveness. It is recommended to take these medications at least **2 hours apart** from iron or zinc supplements. - **Alcohol** can interfere with the absorption of **iron** and **vitamin C**, and chronic alcohol use may exacerbate deficiencies of **zinc** and **folic acid**.

Pregnancy Category Note

Information not available

Adult Dose

For adults, the typical dosage is: - **Iron**: 20–65 mg of elemental iron per day, depending on the severity of the deficiency. - **Folic Acid**: 400 mcg–1 mg per day, particularly for women of reproductive age or during pregnancy. - **Vitamin C**: 60–100 mg per day, which may be higher in individuals with certain deficiencies. - **Zinc**: 11–15 mg per day for general supplementation. The combination is typically administered **once daily**, but higher doses may be prescribed in cases of significant deficiencies or specific clinical conditions.

Child Dose

For children, the doses vary depending on age, weight, and clinical need: - **Iron**: 1–5 mg/kg/day of elemental iron, depending on the child's age and severity of deficiency. - **Folic Acid**: 200–400 mcg/day for children aged 1–18 years. - **Vitamin C**: 25–75 mg/day, depending on the child's age and nutritional requirements. - **Zinc**: 5–15 mg/day for children aged 1–18 years. It is important to avoid excessive doses, particularly of **iron**, in children due to the risk of toxicity. In summary, this combination of **Elemental Iron + Folic Acid + Vitamin C + Zinc** is useful for the **prevention and treatment** of deficiencies in these essential nutrients. Proper dosing and monitoring are key, especially for individuals with underlying health conditions such as **renal impairment** or **iron overload**.

Renal Dose

In patients with **renal impairment**, particularly those with **chronic kidney disease** or **dialysis**, doses of **zinc** and **iron** should be adjusted to avoid toxicity. **Vitamin C** should also be used cautiously in patients with **renal stones** or **impaired renal function**. Regular monitoring of **zinc**, **iron**, and **vitamin C** levels is recommended in these patients to avoid excess accumulation and complications.

Administration

Information not available