INDOLAG RETARD 75mg price in UAE

Overview

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This medicine contains an important and useful components, as it consists of Indomethacin.
INDOLAG RETARD 75mg is available in the market in concentration 75mg/Capsule and in the form of Capsules (Hard Gelatin).

LAGAP SA is the producer of INDOLAG RETARD 75mg and it is imported from SWITZERLAND, The most popular alternatives of INDOLAG RETARD 75mg are listed downward .

Mode Of Action

Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.

Indication

Rheumatoid arthritis
ankylosing spondylitis
and osteoarthritis (degenerative joint disease)
gout
acute non-articular rheumatism (bursitis
synovitis
tendinitis).

Precaution

Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation. Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)

Side Effects

>10% Transient renal insufficiency (40%)
Jaundice (<15%)
Elevated liver function test values (?15%)
Headache (12%) 1-10% Dizziness (3-9%)
Dyspepsia (3-9%)
Epigastric pain (3-9%)
Indigestion (3-9%)
Nausea (3-9%) Symptomatic upper GI ulcers
gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months). Abnormal pain/cramps/distress (<3%)
Constipation (1-3%)
Depression (1-3%)
Diarrhea (1-3%)
Fatigue (1-3%)
Somnolence (1-3%)
Tinnitus (1-3%)
Vertigo (1-3%) <1% Acute interstitial nephritis with hematuria/proteinuria
Acute respiratory distress
Agranulocytosis
Angioedema
Aplastic anemia
Asthma
Bone marrow depression
Congestive heart failure (CHF)
Hemolytic anemia
Leukopenia
Macular and morbilliform eruptions
Pulmonary edema
Thrombocytopenia
Thrombocytopenic purpura
Ulcerative stomatitis
Urticaria

Contra indication

Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin. Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to fatal GI haemorrhage.