Active Substance: Ibuprofen.
Overview
Welcome to Dwaey, specifically on IBULGAN 400mg page.
This medicine contains an important and useful components, as it consists of
Ibuprofenis available in the market in concentration
Ibuprofen
Asthma; renal or hepatic disorders; bleeding disorders; CV disease. Pregnancy, lactation. Lactation: Drug excreted into breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Rheumatoid arthritis, Osteoarthritis, Pain, Fever, Pericarditis, Dysmenorrhea, Patent ductus arteriosus, Inflammation, Musculoskeletal and joint disorders
Active peptic ulcer; hypersensitivity. Neonates with congenital heart disease, suspected necrotising enterocolitis and active bleeding (parenteral).
1-10% Dizziness (3-9%),Epigastric pain (3-9%),Heartburn (3-9%),Constipation (1-3%),Nausea (3-9%),Rash (3-9%),Tinnitus (3-9%),Edema (1-3%),Fluid retention (1-3%),Headache (1-3%),Vomiting (1-3%) <1% Acute renal failure (sometimes with acute tubular necrosis or hyperkalemia, polyuria, azotemia, cystitis, hematuria, decreased creatinine clearance, elevations in blood urea nitrogen (BUN) or creatinine without other manifestations of renal failure) Agranulocytosis,Aplastic anemia,Erythema multiforme,Erythematous macular rashes,Exfoliative dermatitis,Hemolytic anemia (with or without positive direct antiglobulin test results),Neutropenia,Thrombocytopenia (with or without purpura),Toxic epidermal necrolysis (Lyell syndrome) and photosensitivity reactions Potentially Fatal: Severe CV thrombotic events. Severe GI bleeding, ulceration and perforation.
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Ibuprofen inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase-1 and 2. It has anti-inflammatory, analgesic and antipyretic properties.
Increased risk of GI bleeding w/ warfarin, corticosteroids, SSRIs and aspirin. May reduce the natriuretic effects of diuretics. Reduced antihypertensive effect of ACE inhibitors and angiotensin II receptor antagonists. May increase toxicity of lithium and methotrexate. Increased nephrotoxicity w/ ciclosporin and tacrolimus.
Pregnancy category: C; D in 3rd trimester or near delivery. At >30 weeks' gestation; may cause premature closure of ductus arteriosus