Active Substance: Captopril.
Overview
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This medicine contains an important and useful components, as it consists of
Captoprilis available in the market in concentration
Dextrose + Lidocaine Hydrochloride
Hepatic or renal impairment; CHF and following cardiac surgery; bradycardia; respiratory depression; porphyria; elderly or debilitated patients; pregnancy.
Ventricular fibrillation, Ventricular tachycardia, Arrhythmias, Spinal anesthesia, Epidural anesthesia, Haemorrhoids, Surface anesthesia, Regional anesthesia, Cataract surgery, Sympathetic nerve block, Peripheral nerve block, Perianal pain and itching
Hypovolaemia; heart block or other conduction disturbances.
Dizziness, paraesthesia, drowsiness, confusion, respiratory depression and convulsions. Potentially Fatal: Hypotension and bradycardia leading to cardiac arrest; anaphylaxis.
2
Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced. Dextrose is a monosaccharide that is used as a source of calories and water for hydration. It helps to reduce loss of body protein and nitrogen. It also promotes glycogen deposition in the liver.
May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ beta-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.
Information not available