HERRON BIO C 1000mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Bioflavonoids, Calcium ascorbate, Hesperidin, Rosa canina fruit ext. dry conc., Rutin, Sodium Ascorbateis available in the market in concentration

Name

Trifluoperazine

Precaution

Before starting **Trifluoperazine**, it is important for patients to consult their healthcare provider, especially if they have any of the following conditions or concerns: - **Cardiovascular Conditions**: **Trifluoperazine** can cause **orthostatic hypotension**, leading to dizziness or fainting when standing up. It should be used with caution in individuals with **heart disease** or **blood pressure disorders**. - **Parkinson's Disease**: As an **antipsychotic**, **Trifluoperazine** may worsen symptoms of **Parkinson’s disease**, so it should generally be avoided unless absolutely necessary. - **Liver and Kidney Disease**: Patients with **liver** or **kidney disease** may experience altered drug metabolism and clearance, requiring dose adjustments. - **Neuroleptic Malignant Syndrome (NMS)**: **Trifluoperazine**, like other **antipsychotics**, has been associated with **NMS**, a life-threatening condition characterized by **fever**, **muscle rigidity**, **altered mental status**, and **autonomic instability**. If these symptoms occur, immediate medical attention is necessary. - **Pregnancy and Breastfeeding**: **Trifluoperazine** is classified as a **Category C** drug, meaning it may cause harm to the fetus. It should only be used if the benefits outweigh the risks. Caution is also required when breastfeeding, as the drug may pass into breast milk. - **Elderly Patients**: Older adults may be more sensitive to the sedative effects and risk of side effects like **tardive dyskinesia**, a disorder causing involuntary movements. Careful monitoring is essential.

Indication

**Trifluoperazine** is primarily used to manage several psychiatric and behavioral disorders, including: - **Schizophrenia**: It is commonly prescribed as an **antipsychotic** to treat **schizophrenia** and reduce symptoms like delusions, hallucinations, and disorganized thinking. - **Anxiety Disorders**: **Trifluoperazine** can be used for the short-term treatment of **anxiety** or severe agitation, particularly in cases where other medications have not been effective. - **Behavioral Symptoms in Neurological Disorders**: It is sometimes prescribed to manage **aggressive behaviors** associated with certain neurological disorders, like **dementia** or **severe autism**. - **Severe Nausea**: In some cases, **Trifluoperazine** may be used to treat **severe nausea** and vomiting, especially when related to underlying medical conditions or treatments.

Contra indication

**Trifluoperazine** should not be used in the following circumstances: - **Hypersensitivity**: It is contraindicated in patients with a known allergy to **Trifluoperazine** or other **phenothiazines**. - **Severe CNS Depression**: **Trifluoperazine** should not be used in patients with a history of **severe central nervous system depression**, including conditions like **coma** or **alcohol intoxication**, due to the increased risk of sedation and respiratory depression. - **Severe Liver Disease**: Patients with **severe liver dysfunction** should avoid **Trifluoperazine**, as it can worsen liver function and increase the risk of toxicity. - **Bone Marrow Depression**: **Trifluoperazine** is contraindicated in individuals with a history of **bone marrow depression**, as it may exacerbate the condition. - **Concomitant Use with Other CNS Depressants**: Combining **Trifluoperazine** with other **central nervous system depressants** (e.g., benzodiazepines, barbiturates, alcohol) can increase the risk of respiratory depression and sedation.

Side Effect

Common side effects of **Trifluoperazine** include: - **Sedation and Drowsiness**: It can cause **drowsiness**, especially when starting treatment or increasing the dose. - **Extrapyramidal Symptoms**: This includes symptoms such as **tremors**, **muscle stiffness**, **restlessness**, and **bradykinesia**. These side effects are more common with higher doses and long-term use. - **Weight Gain**: **Trifluoperazine** may cause **weight gain**, which can be particularly concerning for patients on long-term therapy. - **Hypotension**: **Orthostatic hypotension** (a sudden drop in blood pressure when standing up) is a common effect, especially when the medication is first started. - **Dry Mouth and Constipation**: These are typical **anticholinergic** side effects and can cause discomfort. - **Sexual Dysfunction**: Some individuals may experience **sexual dysfunction**, including reduced libido or difficulty achieving an erection. - **Tardive Dyskinesia**: Long-term use of **Trifluoperazine** increases the risk of **tardive dyskinesia**, which is characterized by involuntary, repetitive movements, often involving the face, tongue, or limbs. Severe side effects are rare but may include: - **Neuroleptic Malignant Syndrome (NMS)**: This is a life-threatening reaction characterized by **fever**, **muscle rigidity**, **altered mental status**, and **autonomic instability**. Immediate medical attention is required if these symptoms occur. - **Severe Cardiac Effects**: Prolonged use may cause **QT prolongation**, which can lead to **serious heart rhythm disturbances**. - **Agranulocytosis**: Rarely, **Trifluoperazine** can cause **agranulocytosis**, a condition where there is a severe decrease in white blood cells, increasing the risk of infection.

Pregnancy Category ID

3

Mode of Action

**Trifluoperazine** is a **typical antipsychotic** belonging to the **phenothiazine** class. It works by: - **Dopamine Receptor Antagonism**: **Trifluoperazine** blocks **dopamine (D2) receptors** in the brain, particularly in areas involved in mood regulation, thought processes, and behavior. This helps control symptoms of **schizophrenia** and other psychoses by reducing **dopaminergic activity** in overactive areas of the brain. - **Calming Effects on the CNS**: By modulating **dopamine** and other neurotransmitters like **serotonin**, **Trifluoperazine** reduces **agitation**, anxiety, and the severity of **psychotic** symptoms. - **Anti-emetic Action**: It also has **antiemetic properties**, making it effective in treating nausea and vomiting.

Interaction

Several drugs and substances may interact with **Trifluoperazine**, altering its effectiveness or increasing side effects: - **CNS Depressants**: Combining **Trifluoperazine** with other sedative medications, including **alcohol**, **benzodiazepines**, **barbiturates**, or **opioids**, can increase the risk of sedation, respiratory depression, and overdose. - **Anticholinergic Drugs**: Concurrent use with **anticholinergics** (e.g., **atropine**, **antihistamines**) can increase the risk of anticholinergic side effects like **dry mouth**, **constipation**, and **urinary retention**. - **Other Antipsychotics**: Combining **Trifluoperazine** with other **antipsychotic** medications may increase the risk of severe side effects such as **neuroleptic malignant syndrome (NMS)** or **extrapyramidal symptoms** (e.g., tremors, rigidity). - **Antihypertensive Drugs**: Since **Trifluoperazine** can lower blood pressure, combining it with other **antihypertensive medications** may lead to excessive hypotension or dizziness. - **CYP450 Enzyme Interactions**: **Trifluoperazine** is metabolized by the **CYP450 enzyme system**, particularly **CYP2D6**. Drugs that inhibit or induce this enzyme may alter the drug’s levels and effectiveness. For example, **fluoxetine** (a **CYP2D6 inhibitor**) can increase **Trifluoperazine** levels.

Pregnancy Category Note

Information not available

Adult Dose

For **Trifluoperazine**, the typical adult dosing for **schizophrenia** or related psychotic disorders is: - **Initial Dose**: 2-5 mg orally **2-3 times daily**. - **Maintenance Dose**: Depending on the patient’s response, the dose may be adjusted, typically ranging from **5-10 mg daily**. - For **anxiety** or **nausea**, lower doses are used, typically starting at **1-2 mg** once or twice daily, and adjusted as needed. It’s important to note that the exact dosage and frequency should be determined by a healthcare provider, based on the individual patient’s needs.

Child Dose

**Trifluoperazine** is generally not recommended for children under the age of **12 years** due to limited safety data and the potential for serious side effects. In older children or adolescents, the dosage must be carefully adjusted by a healthcare provider, typically starting at a **low dose** (e.g., **0.5-1 mg daily**) with gradual adjustments. As always, it is essential for patients or caregivers to consult a healthcare provider before initiating treatment with **Trifluoperazine**, as the medication requires careful monitoring for side effects and optimal dosing.

Renal Dose

In patients with **renal impairment**, the dose of **Trifluoperazine** may need to be adjusted due to reduced drug clearance. **Monitoring kidney function** is important to minimize the risk of accumulation and potential side effects. The prescribing physician will adjust the dose based on the degree of renal dysfunction.

Administration

Information not available