GLYCILAX FOR ADULT 1g Price

Overview

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This medicine contains an important and useful components, as it consists of
Glycerol (85%)is available in the market in concentration

Name

Glyceryl Trinitrate 0.4% (nitroglycerine) Rectal prep

Precaution

Take special care with Glyceryl Trinitrate 0.4% ointment if patient has: liver or kidney disease to be given heparin haemorrhoids (piles) and notice more bleeding than usual, severe headaches when using ointment, The ointment may lower blood pressure. Blood pressure is more likely to be lowered if drink alcohol whilst you are using ointment. Ointment is not indicated for patients under the age of 18 years.

Indication

Chronic anal fissure

Contra indication

Do not use Glyceryl Trinitrate 0.4% ointment if the patients: are allergic to glyceryl trinitrate or to similar medicines suffer from low blood pressure suffer from heart or blood vessel disorders suffer from closed-angle glaucoma suffer from migraine or recurrent headaches suffer from increased intracranial pressure or high pressure within your skull suffer from anaemia are taking any of the following medicines: sildenafil citrate, tadalafil, vardenafil, medicines for angina or heart pain such as glyceryl trinitrate (GTN), isosorbide dinitrate, amyl or butyl nitrite, medicines for high blood pressure or depression (tricyclic anti-depressants), acetyl cysteine or alteplase

Side Effect

Headache is the most common side-effect when glyceryl trinitrate 0.4% ointment is used. Other side-effects include dizziness, faintness on standing, light-headedness, blurred vision and tiredness & nausea.

Pregnancy Category ID

3

Mode of Action

Glyceryl trinitrate acts on the enzyme nitric oxide stimulating guanylate cyclase in the vascular smooth muscle cells resulting in the relaxation of smooth muscles. It reduces venous return (preload) and facilitates subendocardial blood flow with redistribution into ischaemic areas. It relieves coronary vasospasm and dilates arterioles reducing afterload. It is useful for relief and prevention of anginal attacks.

Interaction

Enhances bioavailability of dihydroergotamine. Glyceryl trinitrate infusion may prolong pancuronium-induced neuromuscular blockade. May reduce the efficacy of heparin, alteplase and noradrenaline when used together. Efficacy of buccal and sublingual preparations may be reduced by drugs that can cause dry mouth due to decreased dissolution. Aspirin and other NSAIDs may reduce the therapeutic response to glyceryl trinitrate. Potentially Fatal: Orthostatic hypotension may be produced by combined use of calcium channel blockers, antihypertensives, phenothiazines and TCAs. Alcohol may cause severe hypotension and collapse.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration