GLUCOSE-Na-K Baxter 50 mg/ml Price

Overview

Welcome to Dwaey, specifically on GLUCOSE-Na-K Baxter 50 mg/ml page.
This medicine contains an important and useful components, as it consists of
Glucose Monohydrate - Sodium acetate trihydrate- Potassium chloride - Magnesium Chloride hexahydrate- Sodium Chlorideis available in the market in concentration

Name

Suxamethonium Chloride

Precaution

Prior to starting **Suxamethonium Chloride**, it is essential for patients to consult their healthcare provider due to the potential for severe side effects and its specific usage in medical settings: - **History of Malignant Hyperthermia**: Suxamethonium can trigger **malignant hyperthermia** in susceptible individuals, a rare but life-threatening condition characterized by rapid increase in body temperature, muscle rigidity, and metabolic acidosis. Patients with a family history of this condition should not use Suxamethonium. - **Neuromuscular Disorders**: Patients with **neuromuscular diseases** like **myasthenia gravis** or **Duchenne muscular dystrophy** are at risk for prolonged paralysis. These conditions can increase the sensitivity to neuromuscular blockers like Suxamethonium, requiring close monitoring and possible dosage adjustment. - **Renal Impairment**: In individuals with **renal failure**, the metabolism of Suxamethonium may be impaired, leading to prolonged effects. Caution is advised, and dosage may need to be adjusted accordingly. - **Cardiovascular Conditions**: Suxamethonium may induce **bradycardia** (slow heart rate), especially during the initial stages of administration. It may also cause **hypotension**. Careful monitoring of heart rate and blood pressure is advised, especially in patients with pre-existing cardiovascular conditions. - **Electrolyte Imbalance**: Suxamethonium can cause **hyperkalemia** (elevated potassium levels), which can be dangerous, particularly in patients with underlying **renal disease**, **burns**, **trauma**, or those who are immobile. **Potassium levels** should be checked before administration. - **Pregnancy and Lactation**: Suxamethonium should be used with caution in **pregnant** or **breastfeeding** women. Its safety during pregnancy has not been well established, and it should only be used when absolutely necessary, with careful monitoring.

Indication

Suxamethonium Chloride is primarily used as a **depolarizing neuromuscular blocker** in clinical settings for: - **Induction of Muscle Paralysis during Surgery**: Suxamethonium is used to induce short-term muscle relaxation or paralysis during surgeries or medical procedures, such as intubation, to facilitate easier ventilation and control of the airway. - **Facilitation of Endotracheal Intubation**: It is commonly used in the **emergency setting** to assist with the placement of an **endotracheal tube** when rapid muscle relaxation is necessary. - **Electroconvulsive Therapy (ECT)**: Suxamethonium may be used during **ECT** to prevent injury from muscle contractions. - **Facilitation of Mechanical Ventilation**: In some cases, it is used to assist with mechanical ventilation in patients who need temporary paralysis due to respiratory distress or surgery.

Contra indication

Suxamethonium should be avoided in the following conditions: - **History of Malignant Hyperthermia**: As mentioned earlier, this life-threatening condition is triggered by **Suxamethonium**. Patients with a known history of malignant hyperthermia or those who are at risk should avoid this drug. - **Severe Burns or Trauma**: Patients with severe burns or extensive trauma, especially within the first few days, are at higher risk for **hyperkalemia** when given Suxamethonium due to the upregulation of **muscle acetylcholine receptors**. - **Renal Failure**: Suxamethonium is metabolized by the liver, and its elimination is affected by renal function. In patients with severe renal impairment, its effects may be prolonged, increasing the risk of **respiratory failure** and **prolonged paralysis**. - **Myopathies or Neuromuscular Disorders**: Individuals with **muscular dystrophies** (e.g., Duchenne) or **myasthenia gravis** are more sensitive to Suxamethonium, and its use should be avoided or used cautiously under close supervision.

Side Effect

The common and serious side effects of **Suxamethonium** include: - **Hyperkalemia**: The most serious side effect of Suxamethonium is an **increase in potassium levels** in the blood, which can lead to **cardiac arrhythmias** and **cardiac arrest**. Patients should have their potassium levels checked before administration, especially those with risk factors like **renal failure**, **burns**, or **muscle disorders**. - **Bradycardia**: **Suxamethonium** can cause a temporary slowing of the heart rate, especially after the initial administration. This is often managed with **atropine** to counteract the bradycardia. - **Malignant Hyperthermia**: As mentioned previously, Suxamethonium can trigger **malignant hyperthermia**, leading to a rapid rise in body temperature, muscle rigidity, and metabolic abnormalities. Immediate treatment with **dantrolene sodium** is required to manage this condition. - **Prolonged Paralysis**: Some individuals, especially those with **genetic variations** (e.g., **pseudocholinesterase deficiency**), may experience **prolonged paralysis** or **respiratory depression** after the drug wears off. - **Allergic Reactions**: Although rare, Suxamethonium can cause **anaphylactic reactions**, which may present with **swelling**, **difficulty breathing**, or **rash**. - **Muscle Pain**: **Muscle soreness** or **myalgia** is a frequent side effect following Suxamethonium use, particularly in adults. - **Increased Intracranial Pressure (ICP)**: Because of the muscle contraction caused by Suxamethonium, there is a potential for **increased intracranial pressure**, making it unsuitable for patients with **head injuries** or **intracranial hemorrhage**.

Pregnancy Category ID

3

Mode of Action

Suxamethonium is a **depolarizing neuromuscular blocker**, which works by mimicking **acetylcholine** at the neuromuscular junction: - **Initial Depolarization**: When Suxamethonium is administered, it binds to the **acetylcholine receptors** on the muscle cell membrane, causing an initial **depolarization** (muscle contraction). This results in a brief muscle twitch or fasciculation. - **Sustained Blockade**: Unlike acetylcholine, Suxamethonium is not broken down quickly by **acetylcholinesterase**, leading to **persistent depolarization** of the muscle. This prevents the muscle from repolarizing, effectively causing **muscle paralysis**. - **Short Duration**: The paralysis induced by Suxamethonium is short-lived due to its rapid metabolism by **plasma cholinesterase**. However, in patients with **genetic variations** or **liver dysfunction**, this process may be slower, leading to prolonged effects.

Interaction

Suxamethonium interacts with several classes of drugs, including: - **Antibiotics**: Certain **antibiotics** like **aminoglycosides** (e.g., gentamicin, tobramycin) can enhance the neuromuscular blocking effect of Suxamethonium. **Polymyxins** and **clindamycin** can also increase the risk of respiratory depression and muscle paralysis. - **Local Anesthetics**: **Local anesthetics** (e.g., lidocaine) may potentiate the effects of Suxamethonium, causing prolonged paralysis or respiratory distress. - **Other Neuromuscular Blockers**: **Non-depolarizing neuromuscular blockers** (e.g., vecuronium, rocuronium) may interact with Suxamethonium, either enhancing or antagonizing its effects. If used together, careful dosing and monitoring are required. - **Diuretics**: **Thiazide diuretics** may increase the risk of **hyperkalemia** when combined with Suxamethonium, especially in patients with underlying renal or cardiac issues. - **Cholinesterase Inhibitors**: Medications that inhibit **cholinesterase** (e.g., **neostigmine**) may reverse the effects of **non-depolarizing** neuromuscular blockers but may enhance the effect of **Suxamethonium**.

Pregnancy Category Note

Information not available

Adult Dose

The typical dosage for **Suxamethonium Chloride** in adults is: - **Intubation**: A **single bolus dose** of **1–1.5 mg/kg** intravenously is usually sufficient to achieve muscle paralysis for **2–5 minutes**, allowing for **endotracheal intubation**. - **Maintenance**: If additional doses are required for prolonged procedures, they are typically given in small increments of **0.5–1 mg/kg**. The dosing should always be adjusted based on the patient's response and condition, with close monitoring of vital signs, especially **respiratory function**.

Child Dose

In pediatric patients, the recommended dose of **Suxamethonium** is generally: - **0.5–1 mg/kg** intravenously, with a maximum dose of **1.5 mg/kg**. Pediatric patients may have a quicker response to the drug than adults, so the onset and duration of muscle relaxation should be monitored. As always, it is crucial for patients to consult with their healthcare provider prior to the administration of **Suxamethonium Chloride**, particularly for those with underlying medical conditions or who are undergoing surgeries or procedures.

Renal Dose

Suxamethonium is primarily metabolized in the **plasma**, so **renal impairment** does not typically require dosing adjustments. However, care should be taken in patients with severe renal dysfunction as the drug’s effects may be prolonged due to impaired metabolism.

Administration

Information not available