GLUCAGEN 1mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Glucagon (GE) HClis available in the market in concentration

Name

Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenyl propionate + Testosterone Propionate

Precaution

Before using a combination of **Testosterone Decanoate**, **Testosterone Isocaproate**, **Testosterone Phenylpropionate**, and **Testosterone Propionate**, patients should consider the following precautions: - **Hypersensitivity**: Individuals with known **allergic reactions** to any form of testosterone or components of this combination should avoid its use. - **Pregnancy and Breastfeeding**: These formulations are **contraindicated during pregnancy** as they can cause virilization (development of male characteristics) in a female fetus. Additionally, **testosterone** can be excreted in **breast milk**, so it should not be used during breastfeeding. - **Prostate Health**: Testosterone therapy can stimulate **prostate cancer** growth. It should not be used in men with **prostate cancer** or **benign prostatic hyperplasia (BPH)** without careful medical supervision. Regular monitoring of prostate health is advised. - **Cardiovascular Disease**: Testosterone therapy can increase the risk of **heart attack**, **stroke**, and **venous thromboembolism**. Individuals with a history of **heart disease**, **high blood pressure**, or **stroke** should use this medication with caution. - **Liver Function**: Caution is advised in patients with existing **liver disease** or dysfunction. Regular monitoring of liver function is recommended. - **Diabetes**: Testosterone may affect **blood glucose** levels, potentially altering the effectiveness of **insulin** or other antidiabetic drugs. - **Polycythemia**: Long-term testosterone therapy may increase **red blood cell count**, increasing the risk of **thrombosis** (blood clots). Regular monitoring is essential for patients on testosterone therapy.

Indication

This combination of testosterone esters is typically used for the following indications: - **Male Hypogonadism**: It is most commonly used for **testosterone replacement therapy (TRT)** in men with **hypogonadism** or **testosterone deficiency**. Symptoms of testosterone deficiency include **low energy**, **decreased libido**, **erectile dysfunction**, **loss of muscle mass**, and **mood changes**. - **Delayed Puberty**: In adolescent boys with **delayed puberty**, this combination may help initiate the development of secondary sexual characteristics such as **facial hair growth**, **deepening of the voice**, and **increased muscle mass**. - **Testosterone Deficiency**: This treatment is also indicated for symptomatic testosterone deficiency, which can affect various aspects of physical and mental health.

Contra indication

This medication should not be used in the following conditions: - **Pregnancy**: Testosterone is contraindicated during pregnancy due to its potential to cause virilization in female fetuses. - **Breastfeeding**: It should be avoided in nursing mothers as **testosterone** can pass into breast milk. - **Prostate Cancer**: It should not be used in men with **prostate cancer** or those at risk for prostate cancer as testosterone therapy may stimulate the growth of prostate cancer cells. - **Breast Cancer**: This combination is contraindicated in men with **breast cancer**, as testosterone may promote tumor growth. - **Hypersensitivity to Testosterone**: It is contraindicated in individuals who are allergic to testosterone or any of its components.

Side Effect

The common side effects of this combination may include: - **Skin Reactions** at the injection site, such as **redness**, **pain**, or **swelling**. - **Acne** and **oily skin** are common with testosterone therapy due to increased sebaceous gland activity. - **Fluid Retention** or **edema**, leading to swelling in the extremities or face. - **Mood Changes**: Some individuals may experience **irritability**, **mood swings**, or even **aggression** ("roid rage"). - **Sleep Apnea**: **Testosterone therapy** has been linked to an increased risk of **sleep apnea**, especially in older individuals or those who are overweight. - **Gynecomastia**: Testosterone therapy may lead to **breast enlargement** in men, a condition known as **gynecomastia**. - **Erythrocytosis (Increased Red Blood Cell Count)**: Long-term use of testosterone can increase red blood cell production, leading to **polycythemia**, which increases the risk of **blood clots**. More serious, but less common side effects include: - **Prostate Problems**: Exacerbation of **benign prostatic hyperplasia (BPH)** or the development of **prostate cancer**. - **Liver Toxicity**: Although rare with injectable testosterone, long-term use can affect liver function and lead to liver damage. - **Cardiovascular Issues**: Testosterone therapy can elevate the risk of **heart attack**, **stroke**, and **deep vein thrombosis** (DVT), particularly in individuals with pre-existing cardiovascular conditions.

Pregnancy Category ID

5

Mode of Action

This combination of testosterone esters works by mimicking the action of naturally occurring testosterone in the body. - **Testosterone Decanoate**: A long-acting ester that provides a slow and steady release of testosterone over time. It allows for less frequent dosing compared to other forms. - **Testosterone Isocaproate** and **Testosterone Phenylpropionate**: Intermediate esters that provide a balance between the **rapid onset** of action (for immediate therapeutic effect) and prolonged duration. - **Testosterone Propionate**: A fast-acting ester, ensuring that the body receives a quick peak in testosterone levels after injection. These esters, once injected, are absorbed into the bloodstream and bind to **androgen receptors** throughout the body, including in **muscle**, **bone**, and **reproductive tissues**. The binding of testosterone to these receptors results in various biological effects, including: - **Muscle growth** and **increased strength** due to enhanced protein synthesis. - **Development of male secondary sexual characteristics** such as facial hair, deep voice, and increased libido. - **Improvement in mood**, **energy levels**, and **cognitive function**. - **Stimulation of erythropoiesis**, leading to an increase in red blood cell count.

Interaction

**Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenylpropionate + Testosterone Propionate** can interact with several medications and substances: - **Anticoagulants**: **Testosterone** can enhance the effects of **oral anticoagulants** (such as **warfarin**), leading to an increased risk of bleeding. Close monitoring of **INR (international normalized ratio)** is required. - **Corticosteroids**: The combination of testosterone and **corticosteroids** may increase the risk of **edema** (fluid retention) and affect **electrolyte balance**. - **Insulin and Oral Hypoglycemic Agents**: **Testosterone** can reduce insulin sensitivity, requiring adjustments in **insulin** doses or other **oral hypoglycemic agents** for diabetic patients. - **Cytochrome P450 Enzyme Inhibitors**: Medications that inhibit **CYP3A4**, such as **ketoconazole**, may increase testosterone levels, while **CYP3A4 inducers** (e.g., **carbamazepine**, **phenytoin**) may lower testosterone levels. - **Other Hormonal Treatments**: Using testosterone with other **hormonal therapies** (like **estrogen** or **progestins**) can interfere with hormone levels and may require dose adjustments.

Pregnancy Category Note

Information not available

Adult Dose

For **Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenylpropionate + Testosterone Propionate** injections, the typical dosage is: - **For Hypogonadism or Testosterone Deficiency**: The usual dose is **1-2 mL (200-400 mg)** injected **intramuscularly every 2-4 weeks**. Dosing frequency can vary based on the individual patient’s response and testosterone levels. Adjustments may be needed based on therapeutic response. - **For Delayed Puberty**: Dosage is typically tailored to the individual adolescent’s needs, with injections given every **1-4 weeks**, depending on the desired outcome.

Child Dose

**Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenylpropionate + Testosterone Propionate** is **not recommended** for use in children unless under medical supervision for specific indications such as **delayed puberty**. The exact dosage will depend on the child's condition and developmental needs, and it should be prescribed and monitored by a pediatric endocrinologist. --- This combination of **testosterone esters** is a potent therapy for restoring testosterone levels in individuals with **hypogonadism** or those needing hormone therapy for other conditions. As with all hormone therapies, it is critical to consult a healthcare provider before starting treatment to ensure it is appropriate for your specific condition and to monitor for potential side effects or complications.

Renal Dose

**Testosterone Decanoate + Testosterone Isocaproate + Testosterone Phenylpropionate + Testosterone Propionate** does not generally require dosage adjustment for patients with **renal impairment**. However, care should be taken in individuals with severe renal disease, as testosterone can affect fluid balance and may exacerbate certain conditions in patients with compromised kidney function. Regular monitoring of renal function is recommended.

Administration

Information not available