Active Substance: Alendronic acid (as sodium trihydrate).
Overview
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This medicine contains an important and useful components, as it consists of
Alendronic acid (as sodium trihydrate)is available in the market in concentration
Alendronic Acid (Alendronate)
Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min. Lactation: Unknown whether drug is excreted in milk; use with caution.
Osteopetrosis, postmenopausal osteoporosis, Paget's disease of bone.
Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for ?30 min. Pregnancy, lactation.
>10% Hypocalcemia, transient and mild (18%) 1-10% Hypophosphatemia, transient and mild (10%),Abdominal pain (7%),Musculoskeletal pain (4.1%),Dyspepsia (3.6%),Nausea (3.6%),Constipation (3.1%),Diarrhea (3.1%),Flatulence (2.6%),Headache (2.6%),Acid regurgitation (2%),Esophagitis (1.5%),Abdominal distention (1%) <1% Alopecia,Diaphyseal femur fracture,Esophageal cancer,Flu like syndrome,Gastritis,Myalgia,Oropharyngeal ulceration,Pruritus,Rash,Taste perversion,Toxic epidermal necrolysis,Uveitis,Vertigo,Weakness
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Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.
Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.
Information not available