FLEXIBAN 10mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Cyclobenzaprine HClis available in the market in concentration

Name

Cyclobenzaprine Hydrochloride

Precaution

Cardiac disease, history of epilepsy, hepatic impairment, hyperthyroidism, pheochromocytoma, history of mania, psychoses, close-angle glaucoma, history of urinary retention, concurrent electroconvulsive therapy, diabetes. Pregnancy and lactation; elderly, child. Unsafe for use in patients with porphyria. Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended. Lactation: Excretion in milk unknown; use with caution

Indication

Fibromyalgia, Muscle spasm

Contra indication

Recent MI, arrhythmias, severe liver disease.

Side Effect

>10% Drowsiness (up to 39% immediate-release),Dry mouth (21-32%),Dizziness (3-11%) 1-10% Pharyngitis (1-3%),Headache (1-5%),Fatigue (6%),Palpitations (6%),Bad taste in mouth (1-6%),Indigestion (4%),Blurred vision (3%),Constipation (1-3%),Asthenia (1-3%),Confusion (1-3%),Nausea (1-3%),Nervousness (1-3%) <1% Arrhythmia,Hypotension,Palpitation,Syncope,Tachycardia,Vasodilation,Cardiac dysrhythmia (rare),Cholestasis (rare),Hepatitis,Jaundice,Anaphylaxis (rare),Immune hypersensitivity reaction

Pregnancy Category ID

2

Mode of Action

Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the ? and ? motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions.

Interaction

Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol. Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone, artemether with lumefantrine, or sibutramine. CNS effects may be enhanced by other CNS depressants.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration