FENISTIL 0.5mg/5ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Dimethindene maleateis available in the market in concentration

Name

Megestrol Acetate

Precaution

Before starting **Megestrol Acetate**, it is crucial for patients to consult their healthcare provider. This drug should be used with caution under the following conditions: - **Cardiovascular Disease**: Megestrol Acetate may increase the risk of **blood clots**, **stroke**, or **heart disease**, particularly in those with pre-existing cardiovascular conditions. Close monitoring is recommended. - **Diabetes**: Megestrol can alter **blood glucose levels**, leading to either increased or decreased blood sugar, so diabetic patients should monitor their levels regularly. - **Liver Disease**: As **megestrol acetate** is metabolized in the liver, caution should be exercised in patients with **liver disease** (such as **cirrhosis** or **hepatitis**), as liver dysfunction may affect the drug's metabolism. - **Thromboembolic Disorders**: Patients with a history of **deep vein thrombosis (DVT)**, **pulmonary embolism (PE)**, or other thromboembolic events should avoid this medication unless otherwise advised by their doctor. - **Pregnancy and Breastfeeding**: Megestrol Acetate is contraindicated in **pregnancy** as it can cause harm to the fetus. It is also excreted in breast milk, so it should be avoided while breastfeeding unless deemed necessary by a healthcare provider. - **Mood and Behavioral Changes**: Megestrol may cause **mood swings**, **depression**, or **aggressive behavior** in some individuals, and it should be used with caution in patients with a history of mental health conditions.

Indication

Megestrol Acetate is used for various therapeutic indications: - **Appetite Stimulation**: It is primarily prescribed to treat **anorexia** and **weight loss** in patients with **cancer** or **HIV/AIDS**, particularly in cases where these conditions lead to unintended weight loss and poor appetite. - **Endometrial Cancer**: Megestrol is used as a **hormonal therapy** for **endometrial carcinoma**, often in combination with other cancer treatments. - **Breast Cancer**: It is also used as a **palliative treatment** for certain types of **hormone-sensitive breast cancer**. - **Uterine Cancer**: Similar to endometrial cancer, it can be used in the treatment of **uterine cancer**, particularly in cases of advanced or metastatic disease. - **Hormonal Therapy for Postmenopausal Women**: In some cases, Megestrol Acetate may be used as part of a treatment regimen for postmenopausal women with **breast cancer** or **endometrial cancer**.

Contra indication

Megestrol Acetate should not be used under the following conditions: - **Pregnancy**: It is contraindicated in pregnant women due to the risk of **fetal harm**, including potential **miscarriage** or **birth defects**. - **Hypersensitivity**: It should not be used in individuals who have a known hypersensitivity or allergic reaction to **megestrol acetate** or any of its components. - **Active Thromboembolic Disorders**: Patients with a history of **blood clots**, **pulmonary embolism**, or **stroke** should not use this medication as it can increase the risk of **thromboembolic events**. - **Liver Impairment**: Individuals with severe **liver disease**, such as **hepatitis** or **cirrhosis**, should avoid using this medication as the liver plays a significant role in its metabolism.

Side Effect

Common side effects of **Megestrol Acetate** include: - **Weight gain**: This medication is commonly associated with **weight gain**, which is often intentional for patients suffering from significant weight loss. - **Increased appetite**: Megestrol is often used to increase **appetite**, but this can also lead to overeating in some individuals. - **Edema (fluid retention)**: Swelling in the **hands**, **ankles**, or **feet** may occur due to **fluid retention**. - **Mood changes**: It can cause **mood swings**, **irritability**, and, in some cases, **depression** or **aggressive behavior**. - **Gastrointestinal issues**: Some people may experience **nausea**, **vomiting**, or **diarrhea**. - **Acne**: Acne or other **skin rashes** may develop during treatment. - **Hot flashes**: Some individuals may experience **hot flashes** as a result of hormonal changes caused by the drug. Severe side effects (though rare) include: - **Blood clots**: There is an increased risk of **deep vein thrombosis** (DVT) or **pulmonary embolism**. - **Vision changes**: **Blurred vision** or other visual disturbances may occur in some patients. - **Liver dysfunction**: Symptoms such as **yellowing of the skin or eyes** (jaundice) may indicate liver damage. - **Severe allergic reactions**: Rare, but some patients may experience a severe allergic reaction, including swelling of the **face**, **lips**, or **throat**, and difficulty breathing. Patients should report any severe side effects to their healthcare provider immediately.

Pregnancy Category ID

5

Mode of Action

Megestrol Acetate is a **synthetic progestin**, which mimics the effects of the natural hormone **progesterone** in the body. Its mechanism of action involves several key actions: - **Appetite Stimulation**: Megestrol acetate increases appetite by acting on the **hypothalamus**, the part of the brain that regulates hunger. - **Antitumor Effect**: In **breast cancer** and **endometrial cancer**, Megestrol works by inhibiting the actions of **estrogen** on hormone-sensitive tumors. It may slow or stop the growth of these cancers. - **Endometrial Regulation**: Megestrol alters the **endometrial lining** and can be used as a therapeutic agent for endometrial cancer by reducing abnormal cell growth. - **Hormonal Effects**: In certain cancers, Megestrol can suppress **gonadotropin secretion** and alter hormonal signaling, inhibiting the growth of tumor cells that rely on hormones for growth.

Interaction

Megestrol Acetate may interact with a variety of medications and substances, affecting its effectiveness or leading to potential side effects: - **Corticosteroids**: Concurrent use with **corticosteroids** (e.g., **prednisone**) may increase the risk of fluid retention and **edema**. - **Anticoagulants**: Megestrol may alter the effects of **anticoagulants** (e.g., **warfarin**), potentially leading to an increased risk of **bleeding** or **clotting**. Blood clotting parameters should be monitored. - **Cytochrome P450 Enzyme Inhibitors/Inducers**: Drugs that affect **CYP3A4** (such as **ketoconazole**, **ritonavir**, or **phenytoin**) may influence the metabolism of Megestrol Acetate, either increasing or decreasing its effectiveness. - **Diabetes Medications**: Megestrol can affect **blood glucose** levels, so patients taking **insulin** or **oral hypoglycemic agents** should monitor their glucose levels closely. - **Herbal Supplements**: Some herbal products, such as **St. John's Wort**, can induce liver enzymes and may reduce the effectiveness of Megestrol Acetate. Patients should inform their healthcare provider about any other medications, supplements, or herbal products they are taking before starting Megestrol Acetate.

Pregnancy Category Note

Information not available

Adult Dose

The typical dose of **Megestrol Acetate** depends on the condition being treated: - **Anorexia or Weight Loss (Cancer, HIV/AIDS)**: The standard dose is **400 mg to 800 mg orally** per day, taken in divided doses. - **Breast Cancer**: A common dose is **160 mg per day**, divided into 2 doses. - **Endometrial Cancer**: The recommended dose is **160 mg per day**, divided into 2 doses. - **Palliative Care for Cancer**: Megestrol may be used at doses of **40 mg to 320 mg** daily for **appetite stimulation**.

Child Dose

Megestrol Acetate is generally not recommended for use in children unless specifically prescribed by a healthcare provider. It is more commonly used in **adults** for appetite stimulation or cancer therapy. If prescribed, the pediatric dose will depend on the condition being treated and the child’s specific health needs, and it should be adjusted by a pediatric specialist. As with all medications, patients should always consult their healthcare provider before starting, stopping, or changing their treatment regimen with **Megestrol Acetate** to ensure its safety and appropriateness for their health condition.

Renal Dose

There are no specific dosage adjustments required for **Megestrol Acetate** in patients with **renal impairment**. However, it is still important for patients with kidney problems to be monitored closely during treatment.

Administration

Information not available