FACTIVE 320mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Gemifloxacin (as mesylate)is available in the market in concentration

Name

Gemifloxacin

Precaution

Patient w/ known or suspected CNS disorders (e.g. seizure disorders) or other risk factors predisposing to seizures, myasthenia gravis, previous tendon disorders (e.g. rheumatoid arthritis), history of QT interval prolongation, significant bradycardia or acute myocardial ischaemia, uncorrected electrolyte disorders. Kidney, heart or lung transplant recipients. Renal impairment. Pregnancy and lactation. Patient Counselling May impair ability to perform activities that require mental alertness or coordination (e.g. driving, operating machinery). Rest and refrain from doing strenuous physical activity as it may increase risk of tendon rupture. Avoid excessive exposure to sunlight or artificial UV light (e.g. tanning beds) and use protective measures (e.g. sunscreen, wear loose-fitting clothes) if staying outdoors is necessary during therapy. Monitoring Parameters Monitor WBC, signs and symptoms of infection and renal function. Lactation: excretion in milk unknown; do not use unless benefit to mother outweighs risk

Indication

Chronic bronchitis, Community-acquired pneumonia

Contra indication

Hypersensitivity. Patients receiving class IA or III antiarrhythmics.

Side Effect

1-10% Diarrhea (5%),Headache (4%),Nausea (4%),Rash (4%),Transaminases increased (1-4%),Abdominal pain (2%),Dizziness (2%),Vomiting (2%),Neutropenia (1%),Platelets increased (1%),Thrombocythemia (1%),GGT increased (1%) <1% Peripheral neuropathy,Photosensitivity,Tendon rupture

Pregnancy Category ID

3

Mode of Action

The bactericidal action of gemifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Interaction

Additive effect on QT interval prolongation w/ class IA (e.g. quinidine) or class III (e.g. amiodarone) antiarrhythmics and other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Renal clearance reduced w/ probenecid. Decreased absorption w/ Al or Mg-containing antacids, buffered didanosine, sucralfate or dietary supplements containing metal cations (e.g. Zn, Mg, Fe). Increased risk of severe tendon disorders esp in elderly (>60 yr) w/ corticosteroids. May increase prothrombin time, INR and/or bleeding w/ warfarin.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration