EPIVIR 10mg/ml Price
Active Substance: Lamivudine.
Overview
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This medicine contains an important and useful components, as it consists of
Lamivudineis available in the market in concentration
Name
Lamivudine
Precaution
Discontinue use if there is rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin. Discontinue use if clinical signs, symptoms or lab abnormalities suggestive of pancreatitis develop. Hepatomegaly or other risk factors for hepatic impairment. Monitor hepatic function in chronic hepatitis B patients. Exclude HIV infection prior to hepatitis B therapy. Renal impairment. Pregnancy.
Indication
HIV infection, Chronic hepatitis B
Contra indication
Hypersensitivity. Lactation.
Side Effect
>10% Cough,Diarrhea,Fatigue & malaise,Fever (peds),Headache,Musculoskeletal pain,Nausea,Nervous system neuropathy,Pancreatitis,Peripheral neuropathy,Nasal S/S,Vomiting 1-10% Abdominal cramps, abdominal pain,Anorexia &/or decr appetite,Arthralgia,Chills,Depression,Dizziness,Dyspepsia,Insomnia,Myalgia,Rash,Thrombocytopenia,Creatine phosphokinase increased Frequency Not Defined Body fat redistribution,Elevated amylase,Neutropenia,Hepatitis B exacerbation Potentially Fatal: Lactic acidosis associated with severe hepatomegaly and hepatic steatosis.
Pregnancy Category ID
3
Mode of Action
Lamivudine, a nucleoside analogue, is phosphorylated in the body to the active triphosphate form. In the active form, it inhibits hepatitis B virus polymerase and HIV reverse transcriptase enzymes.
Interaction
Renal excretion may be inhibited by high doses of trimethoprim (co-trimoxazole). May antagonise the antiviral action of zalcitabine.
Pregnancy Category Note
Information not available
Adult Dose
Child Dose
Renal Dose
Administration
