DALACIN-C 900mg/6ml I.M/I.V Price

Overview

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This medicine contains an important and useful components, as it consists of
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Name

Allystrenol

Precaution

- Allystrenol should be used with caution in patients with a history of cardiovascular disease, as it can potentially increase blood pressure and affect heart function, especially when used in high doses or over extended periods. - Women with a history of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism) should be monitored closely, as synthetic progestins like allystrenol may increase the risk of blood clots. - It is important to exercise caution when using allystrenol in individuals with liver dysfunction, as the liver plays a key role in metabolizing progestins, and impaired liver function may lead to drug accumulation and increased side effects. - Allystrenol should be used cautiously in women with diabetes or insulin resistance, as it may impact blood sugar levels, particularly when used in high doses or over long periods. - It is essential to monitor patients for signs of depression or mood changes, as synthetic progestins like allystrenol may influence mood and mental health, although this is relatively rare. - Use of allystrenol may affect the timing of menstrual cycles. It should not be used in cases where the woman is trying to conceive or is pregnant. - Allystrenol should be discontinued if any signs of severe adverse reactions, including jaundice, severe headaches, or visual disturbances, are noticed, as these could indicate liver dysfunction or other serious conditions. - If a woman is breastfeeding, caution should be used, as it is not clear whether allystrenol passes into breast milk and what potential effects it may have on a nursing infant.

Indication

- Allystrenol is primarily indicated for the treatment of threatened miscarriage or recurrent miscarriage, as it can help support pregnancy by maintaining the uterine lining and preventing early pregnancy loss. - It is used to treat conditions related to progesterone deficiency, such as luteal phase defects, where there is insufficient progesterone to support pregnancy. - Allystrenol can also be used for the treatment of certain menstrual disorders, such as secondary amenorrhea (absence of menstruation) or irregular bleeding, by stabilizing the menstrual cycle. - It is sometimes used in the treatment of dysfunctional uterine bleeding, a condition in which irregular or heavy bleeding occurs due to hormonal imbalances. - In some cases, allystrenol is prescribed as part of hormone replacement therapy (HRT) for menopausal women to help balance hormone levels and reduce symptoms of menopause. - Allystrenol may also be used off-label in certain cases to manage symptoms of endometriosis or other conditions involving hormonal imbalances, although it is not a first-line treatment.

Contra indication

- Allystrenol is contraindicated in women who are pregnant, unless there is a clear medical need, such as to prevent miscarriage. It is not recommended for use during pregnancy without careful consideration of risks versus benefits. - It should not be used in individuals with a history of breast cancer or any other hormone-sensitive cancer, as progestins like allystrenol may exacerbate these conditions by stimulating hormone receptors. - Allystrenol is contraindicated in women with a history of thromboembolic disorders (e.g., stroke, deep vein thrombosis), as progestins may increase the risk of clot formation. - It should not be used in patients with undiagnosed vaginal bleeding, as the cause of bleeding should be evaluated before initiating treatment. - Women with severe liver dysfunction or cirrhosis should avoid allystrenol, as the drug is metabolized in the liver, and its clearance may be compromised in patients with liver disease. - Allystrenol is contraindicated in women with a known hypersensitivity or allergy to any of the components of the drug. - The drug should not be used in patients with undiagnosed or untreated endometrial hyperplasia, as it may exacerbate the condition. - Caution is advised in patients with a history of depression or mental health disorders, as synthetic progestins can sometimes exacerbate mood symptoms.

Side Effect

- Common side effects of allystrenol include gastrointestinal disturbances, such as nausea, vomiting, or abdominal discomfort, especially during the early stages of treatment. - Some women may experience headaches, dizziness, or fatigue, which can impact daily activities. - There is a potential for weight gain due to fluid retention or increased appetite, a common side effect of progestins like allystrenol. - Mood changes, including irritability, anxiety, or depression, may occur, particularly during long-term use. - Breast tenderness or enlargement is another possible side effect, as allystrenol can influence breast tissue in a manner similar to other hormonal medications. - Changes in menstrual patterns, such as spotting or irregular bleeding, may occur, especially during the initiation of therapy. - Some women may experience skin changes such as acne or a rash as a result of allystrenol. - In rare cases, allystrenol can cause more serious side effects, such as jaundice (yellowing of the skin or eyes), visual disturbances, or severe abdominal pain, which may indicate liver dysfunction. - Long-term use of allystrenol may be associated with an increased risk of certain hormonal-related conditions, such as endometrial hyperplasia, particularly if not monitored properly. - If a patient experiences signs of a blood clot (swelling, pain in the legs, difficulty breathing), they should seek medical attention immediately, as progestins can increase the risk of clotting disorders.

Pregnancy Category ID

0

Mode of Action

- Allystrenol is a synthetic progestin that mimics the natural hormone progesterone, which plays a crucial role in regulating the menstrual cycle and supporting pregnancy. - The primary mode of action of allystrenol is to enhance the secretory activity of the endometrial lining of the uterus, making it more receptive to a fertilized egg. This action helps support pregnancy and prevent early miscarriage in cases of luteal phase deficiency. - Allystrenol acts on progesterone receptors in the uterus and other reproductive tissues, where it promotes the thickening of the uterine lining, necessary for maintaining early pregnancy. - It also inhibits the action of estrogen, which can be important in preventing excessive uterine bleeding and stabilizing menstrual cycles. - Allystrenol’s effects on the pituitary gland reduce the secretion of gonadotropins (FSH and LH), thus helping regulate the menstrual cycle and prevent ovulation when used as part of hormone therapy. - Additionally, allystrenol can suppress uterine contractions and increase cervical mucus viscosity, creating a more favorable environment for pregnancy maintenance. - In hormone replacement therapy (HRT), allystrenol helps alleviate menopausal symptoms by stabilizing hormonal levels and preventing the overgrowth of the uterine lining.

Interaction

- Allystrenol may interact with other medications that affect the liver enzymes responsible for metabolizing drugs, such as CYP450 inhibitors or inducers. Drugs that increase or decrease the activity of these enzymes may alter allystrenol's effectiveness. - The use of allystrenol with other hormonal medications, such as estrogens, may increase the risk of side effects, including blood clotting or mood changes. If used together, monitoring for adverse effects is recommended. - Certain anticonvulsants (e.g., phenytoin, carbamazepine) or antibiotics (e.g., rifampin) may reduce the effectiveness of allystrenol by increasing the metabolism of the drug. - The combination of allystrenol with anticoagulants (e.g., warfarin) may alter the anticoagulant effect. Close monitoring of blood clotting parameters (INR) is recommended if both drugs are used together. - Allystrenol may affect the metabolism of diabetes medications, leading to potential changes in blood glucose levels. Monitoring is recommended for diabetic patients. - When used with corticosteroids, allystrenol may increase the risk of fluid retention or other corticosteroid-related side effects, and dose adjustments may be required. - Alcohol can exacerbate some of the side effects of allystrenol, including dizziness and mood changes, so its consumption should be limited during treatment. - The use of allystrenol with other progestins should be avoided unless advised by a healthcare provider, as the combined effects may increase the risk of adverse effects such as thromboembolic events.

Pregnancy Category Note

Information not available

Adult Dose

- The typical adult dose of allystrenol for treating threatened miscarriage or recurrent miscarriage is 5 mg taken orally, 2 to 3 times daily. The exact dose and frequency may vary depending on the patient's condition and response to treatment. - For menstrual disorders, such as secondary amenorrhea or dysfunctional uterine bleeding, the usual dosage is 5 mg to 10 mg once daily, with treatment often lasting several days to weeks. - In hormone replacement therapy (HRT), allystrenol is often used in combination with estrogen. The dose will vary depending on the specific HRT regimen, but doses of 5-10 mg daily are common. - Doses may be adjusted based on the patient’s response to treatment, and the lowest effective dose should be used to minimize the risk of side effects.

Child Dose

- Allystrenol is not commonly used in pediatric patients, and its safety and efficacy in children have not been established. Therefore, it is generally not recommended for use in children. - If used in rare cases under the guidance of a healthcare provider, the dosage would be carefully adjusted based on the child’s weight, age, and condition, but this is uncommon.

Renal Dose

- Allystrenol does not typically require dose adjustments for patients with mild to moderate renal impairment. However, in individuals with severe renal dysfunction, caution should be exercised when using any hormonal therapy, including allystrenol, as the metabolism and elimination of the drug may be altered. - Close monitoring of renal function is recommended during treatment, particularly if the patient has a history of renal issues or is on other medications that affect renal function.

Administration

Information not available