Active Substance: Azilsartan medoxomil (as potassium).
Overview
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This medicine contains an important and useful components, as it consists of
Azilsartan medoxomil (as potassium)is available in the market in concentration
Azilsartan Medoxomil
Correct vol or salt depletion prior to administration. Renal (moderate to severe) & hepatic (severe) impairment. Pregnancy (1st trimester) & lactation. Childn <18 yr. Monitor serum K in patients taking K-sparing diuretics, salt substitutes containing K & drugs that increase K levels (eg heparin) & creatinine levels in patients w/ renal impairment & type 2 DM. Aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy. Lactation: unknown whether distributed in breast milk, decide on alternate antihypertensive therapy or do not breastfeed
Treatment of Hypertension, alone or in combination w/ other antihypertensive agents.
Hypersensitivity. Pregnancy.
1-10% Diarrhea (2%) <1% Nausea,Asthenia,Fatigue,Muscle spasm,Dizziness,Postural hypotension,Cough
4
Angiotensin II blocker; displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water absorption, and hypertrophic responses. May induce more complete inhibition of renin-angiotensin system compared with ACE inhibitors; does not affect response to bradykinin. Inhibits the pressor effects of an angiotensin II infusion in a dose-related manner.
Reversibly increases serum conc & toxicity of lithium; attenuated antihypertensive effects & risk of worsening of renal function may occur w/ NSAIDs. Hyperkalemia w/ K-sparing diuretics & K supplements.
Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)