Active Substance: Memantine HCl.
Overview
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This medicine contains an important and useful components, as it consists of
Memantine HClis available in the market in concentration
Memantine Hydrochloride
Renal impairment; epilepsy. Pregnancy and lactation. Closely monitor patients with recent MI, uncompensated CHF, uncontrolled hypertension. Predisposition to convulsions; conditions that increase urinary pH. Lactation: Unknown whether drug is excreted into breast milk; use with caution
Alzheimer's dementia.
Hypersensitivity to memantine or components of the formulation. Severe renal impairment.
1-10% Dizziness (7%),Confusion (6%),Headache (6%),Constipation (5%),Cough (4%),Hypertension (4%),Backache (3%),Pain (3%),Somnolence (3%),Syncope (3%),Vomiting (3%),Dyspnea (2%),Fatigue (2%) <1% Acute renal failure,Cerebral infarction,Cerebrovascular accident,Deep venous thrombosis,Hepatitis, liver failure,Intracranial hemorrhage,Neuroleptic malignant syndrome,Seizure (including grand mal),Stevens-Johnson syndrome,Transient ischemic attack
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Memantine, a derivative of amantadine, is a noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist. It affects transmission of glutamate, the primary excitatory neurotransmitter in the CNS. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in excitotoxicity and neuronal cell death.
May increase effects of antimuscarinics and dopaminergics. May reduce effects of antipsychotics and barbiturates. May alter effects of dantrolene, baclofen. Reduced clearance with carbonic anhydrase inhibitors and sodium bicarbonate. Potentially Fatal: Increased risk of adverse effects with amantadine, dextromethorphan or ketamine.
Information not available