DYAZIDE Price

Overview

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This medicine contains an important and useful components, as it consists of
Triamterene, Hydrochlorothiazideis available in the market in concentration

Name

Hydrochlorothiazide + Triamterene

Precaution

Renal and hepatic impairment; cirrhosis; DM; hyponatraemia; hyperuricaemia; history of nephrolithiasis; depleted folic acid stores. Monitor electrolyte concentrations closely, especially potassium levels. Observe for signs of liver damage, blood dyscrasias or other idiosyncratic reactions. Discontinue treatment if urinary calculus is passed. Pregnancy and elderly. Lactation: Not recommended; discontinue drug or do not nurse

Indication

Hypertension, Oedema

Contra indication

severe renal or hepatic impairment, preexisting or drug-induced hyperkalemia, patients at risk of respiratory or metabolic acidosis. Lactation.

Side Effect

Triamterene Jaundice,Weaknes,Headache,Azotemia,Dizziness,Fatigue,Xerostomia,Photosensitivity,Rash,Diarrhea,Nausea,Vomiting,Hyperuricemia,Hyper/hypokalemia,Interstitial nephritis Hydrochlorothiazide Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia

Pregnancy Category ID

3

Mode of Action

Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions. Triamterene is a potassium sparing diuretic which appears to act mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of potassium. It adds to the natriuretic but reduces the kaliuretic effects of other diuretics. It is structurally similar to folate and has anti-folate activity.

Interaction

May enhance toxicity of digitalis glycosides, neuromuscular-blocking action of competitive muscle relaxants, effect of antihypertensives. Increased risk of postural hypotension w/ alcohol, barbiturates, opioids. K-depleting effect enhanced by corticosteroids, lithium, ACTH, carbenoxolone.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration