DOXYLAG 100mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Doxycyclineis available in the market in concentration

Name

Doxycycline

Precaution

The use of drugs of tetracycline group during tooth development (last half of pregnancy, infancy and childhood to the age of 12 years) may cause permanent discoloration of the teeth. Tetracyclines, therefore, should not be used in this age group unless other drugs are not likely to be effective or are contraindicated. Lactation: Enters breast milk; Not recommended

Indication

Acne, Susceptible infections, Syphilis, Uncomplicated gonorrhoea, Relapsing fever and louse-borne typhus, Scrub typhus

Contra indication

It is contraindicated to patients with known hypersensitivity to any of the tetracyclines. It is also contraindicated in severe hepatic disorder and patients with systemic lupas erythematosus. Concomitant intake of alkalis, antacids and iron may interfere with the absorption of Doxycycline. It is advisable to avoid giving doxycycline in conjunction with penicillin. Doxycycline should not be used in pregnant women unless, in the judgment of the physician, it is essential for the welfare of the patient.

Side Effect

Hypotension, pericarditis, angioneurotic oedema, dyspnoea, serum sickness, peripheral oedema, tachycardia, urticaria, haemolytic anaemia, thrombocytopenia, neutropenia, porphyria, eosinophilia, brown-black microscopic discolouration of thyroid tissue, headache, bulging fontanelles in infants and benign intracranial HTN in adults, blurring of vision, scotomata, diplopia, tinnitus, abdominal pain, stomatitis, anorexia, nausea, vomiting, diarrhoea, dyspepsia, oesophageal ulceration, discolouration of teeth, enamel hypoplasia, transient increases in LFT and BUN, jaundice, pancreatitis, rashes, exfoliative dermatitis, photo-onycholysis, photosensitivity, arthralgia, myalgia, vaginitis. Potentially Fatal: Anaphylactoid reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, Clostridium difficile-associated disease (CDAD), hepatotoxicity.

Pregnancy Category ID

4

Mode of Action

Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has bacteriostatic activity against a broad range of gm+ve and gm-ve bacteria.

Interaction

Concomitant use w/ isotretinoin is known to cause pseudotumour cerebri. Prolonged prothrombin time w/ anticoagulants (e.g. warfarin). May interfere w/ the bactericidal action of penicillin. Impaired absorption w/ antacids containing Al, Ca, or Mg, oral Zn, Fe salts, and bismuth preparations. Increased metabolism w/ phenobarbital, carbamazepine, primidone and phenytoin. Risk of breakthrough bleeding w/ oral contraceptives. Increased plasma concentration of ciclosporin. Decreased half-life w/ hepatic enzymes inducers (e.g. rifampicin). Potentially Fatal: Concurrent use w/ methoxyflurane may result to fatal renal toxicity.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration