DIALAG MICROCLYSMA 10mg/2.5ml price in UAE

Overview

Welcome to Dwaey, specifically on DIALAG MICROCLYSMA 10mg/2.5ml Rectal Solution page.
This medicine contains an important and useful components, as it consists of Diazepam.
DIALAG MICROCLYSMA 10mg/2.5ml is available in the market in concentration 4mg/ml and in the form of Rectal Solution.

LAGAP SA is the producer of DIALAG MICROCLYSMA 10mg/2.5ml and it is imported from SWITZERLAND, The most popular alternatives of DIALAG MICROCLYSMA 10mg/2.5ml are listed downward .

Mode Of Action

Diazepam is a long-acting benzodiazepine w/ anticonvulsant, anxiolytic, sedative, muscle relaxant and amnestic properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.

Indication

Agitation
Anxiety
Anaesthesia
Seizures
Insomnia
Muscle spasms
Alcohol withdrawal syndrome

Precaution

mpaired renal and hepatic function, respiratory disease, organic cerebral changes, elderly, psychotic patients, epileptics, history of alcohol or drug addiction, impaired gag reflux, obese patients. May cause CNS depression. Discontinue treatment if patient develops psychiatric and paradoxical reactions. Caution when used in patients with depression or anxiety associated with depression, especially if patient has suicidal risk. May increase risk of falls. Safety and efficacy of the inj have not been established in children <1 mth of age. Safety and efficacy of oral use have not been established in children <6 mth of age. Safety and efficacy of rectal gel have not been established in children <2 yr of age. Abrupt withdrawal or large dose reduction may cause rebound or withdrawal symptoms. Lactation: Enters breast milk; not recommended

Side Effects

1-10% Atax (3%)
Euphoria (3%
rectal gel)
Incoordination (3%
rectal gel)
Somnolence (>1%)
Rash (3%
rectal gel)
Diarrhea (4%
rectal gel) Frequency Not Defined Common
Hypotension
Fatigue
Muscle weakness
Respiratory depression
Urinary retention
Depression
Incontinence
Blurred vision
Dysarthria
Headache
Skin rash
Changes in salivation
Serious
Neutropenia
Jaundice Local effects: Pain
swelling
thrombophlebitis
carpal tunnel syndrome
tissue necrosis
Phlebitis if too rapid IV push Potentially Fatal: Respiratory and CNS depression
coma.

Contra indication

Hypersensitivity; myasthenia gravis, preexisting CNS depression or coma, respiratory depression; acute pulmonary insufficiency or sleep apnoea syndrome; severe hepatic impairment; acute narrow angle glaucoma; children <6 mth (oral); pregnancy and lactation.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Interaction

May significantly enhance CNS depressant effect w/ antivirals (e.g. amprenavir, ritonavir). May enhance CNS depressant effect w/ anaesth, narcotic analgesics, antidepressants, antipsychotics, anxiolytics, antiepileptics, antihistamines, antihypertensives, muscle relaxants (e.g. tizanidine, baclofen), nabilone. May decrease clearance w/ antibacterials that interfere w/ metabolism by hepatic enzymes (e.g. isoniazid and erythromycin), OC, cimetidine, omeprazole. May increase clearance w/ antibacterials which are known inducers of hepatic enzymes (e.g. rifampicin). May increase serum level w/ disulfiram. May reduce clearance of digoxin. May reduce therapeutic effect w/ theophylline. Reversible deterioration of parkinsonism w/ levodopa.