CORTIMYCINE Price

Overview

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This medicine contains an important and useful components, as it consists of
Neomycin, Hydrocortisone acetateis available in the market in concentration

Name

Retapamulin 1% Topical

Precaution

Before using **Retapamulin 1% topical**, it is important for patients to consult their healthcare provider to ensure it is appropriate for their condition. The following precautions should be considered: - **Allergic Reactions**: As with any medication, there is a risk of hypersensitivity. If a rash, itching, or swelling occurs, the patient should stop using the medication and contact their healthcare provider. - **Pregnancy and Lactation**: The safety of Retapamulin during pregnancy and breastfeeding has not been fully established. Pregnant or breastfeeding women should consult their healthcare provider before using the medication. - **Application to Sensitive Areas**: Retapamulin is intended for **topical use only**. It should not be applied to the eyes, mouth, or mucous membranes, and care should be taken to avoid contact with broken skin or open wounds, as these areas may increase systemic absorption. - **Bacterial Resistance**: Overuse or misuse of Retapamulin can contribute to the development of bacterial resistance. It should only be used as directed by a healthcare provider and should not be used for viral or fungal infections. - **Infection Type**: Retapamulin is effective for **skin infections** caused by certain bacteria. It is important to confirm that the infection is bacterial and not due to a viral or fungal cause before initiating therapy.

Indication

Retapamulin 1% topical is indicated for the treatment of **bacterial skin infections**, including: - **Impetigo**: A common and highly contagious bacterial skin infection, often caused by **Streptococcus pyogenes** or **Staphylococcus aureus**, including **methicillin-sensitive Staphylococcus aureus** (MSSA). - **Other Superficial Skin Infections**: Retapamulin is used for other localized skin infections caused by susceptible bacteria, typically involving the epidermis or upper layers of the dermis. - **Wound Infections**: It can be used for superficial wound infections, though it should only be applied to intact skin or superficial wounds. - **Off-label Use**: While primarily used for impetigo and other superficial skin infections, healthcare providers may use it off-label for other bacterial skin conditions when appropriate.

Contra indication

Retapamulin should not be used in the following situations: - **Hypersensitivity to Retapamulin**: The drug is contraindicated in patients who are allergic to **Retapamulin** or any of its components. Allergic reactions may include rash, pruritus, or swelling. - **Infections Caused by Non-Susceptible Organisms**: Retapamulin is only effective against certain bacterial pathogens. It should not be used to treat infections caused by **viruses**, **fungi**, or **non-susceptible bacteria** (such as **methicillin-resistant Staphylococcus aureus** [MRSA]).

Side Effect

Retapamulin is generally well-tolerated, but like any medication, it may cause side effects. These include: **Common Side Effects**: - **Application Site Reactions**: These include **itching**, **burning**, **stinging**, or **redness** at the site of application. These are typically mild and go away once the medication is discontinued. - **Dry Skin**: Some patients may experience **dryness** or peeling in the treated area. - **Rash**: A mild **rash** may appear on the skin around the treated area. **Serious Side Effects**: - **Severe Allergic Reaction**: Although rare, some patients may experience a severe allergic reaction, including **swelling of the face or throat**, **difficulty breathing**, or **hives**. If these symptoms occur, treatment should be discontinued immediately, and emergency medical help should be sought. - **Signs of Infection**: If the skin infection worsens or does not improve after a few days of treatment, the patient should contact their healthcare provider as this may indicate an infection caused by bacteria not susceptible to Retapamulin.

Pregnancy Category ID

2

Mode of Action

Retapamulin is a **topical antibiotic** that works by inhibiting bacterial protein synthesis. Its mechanism involves: - **Inhibition of Protein Synthesis**: Retapamulin binds to the **50S ribosomal subunit** of bacteria, inhibiting the formation of proteins necessary for bacterial growth and reproduction. This effectively halts bacterial replication, leading to the clearance of the infection. - **Bacteriostatic Action**: Retapamulin is **bacteriostatic**, meaning it prevents the growth and multiplication of bacteria, rather than killing them directly. It helps control the bacterial load in infected areas and facilitates healing. Retapamulin has a **narrow spectrum of activity**, primarily targeting **Gram-positive bacteria**, including **Streptococcus pyogenes** and **Staphylococcus aureus** (including **MSSA**).

Interaction

Topical **Retapamulin 1%** is unlikely to interact significantly with other medications when used topically, as it has minimal systemic absorption. However, the following interactions should be considered: - **Topical Medications**: When using multiple topical treatments, including corticosteroids or other antibiotics, it is important to allow time between the application of different products to avoid potential interactions or reduced effectiveness. Topical steroids may interfere with the action of Retapamulin if applied in large amounts or over extended periods. - **Other Antibiotics**: If patients are using oral or systemic antibiotics, there may be overlapping effects, but there is no significant direct interaction with oral antibiotics like **penicillins** or **cephalosporins**. - **Antifungal or Antiviral Treatments**: Retapamulin should not be used in combination with antifungal or antiviral treatments unless otherwise directed by a healthcare provider, as it is specifically designed for bacterial infections.

Pregnancy Category Note

Information not available

Adult Dose

The recommended dose for **Retapamulin 1% topical** in adults is: - **Impetigo**: Apply a thin layer of **Retapamulin** to the affected area **twice daily** for up to **5 days**. The treatment should be continued for the full duration, even if symptoms improve before completing the course. - **Other Skin Infections**: For other bacterial skin infections, follow the instructions provided by the healthcare provider, typically involving application **twice daily** for several days.

Child Dose

The recommended dose for children aged **9 months and older** is: - **Impetigo**: A thin layer of **Retapamulin 1%** should be applied to the affected area **twice daily** for up to **5 days**. - **Other Skin Infections**: For other types of superficial bacterial skin infections, follow the healthcare provider's dosing instructions. Retapamulin is **not recommended** for children younger than 9 months. As always, it is essential to consult a healthcare provider before beginning any treatment with **Retapamulin**, particularly to confirm that the infection is bacterial and suitable for treatment with this specific antibiotic.

Renal Dose

There are no specific dose adjustments for patients with **renal impairment** as Retapamulin is applied topically and has minimal systemic absorption. However, patients with **severe renal impairment** should consult their healthcare provider before using the medication.

Administration

Information not available