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Overview

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This medicine contains an important and useful components, as it consists of
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Name

Nandrolone

Precaution

Before using **Nandrolone**, patients should consult their healthcare provider to determine if it is suitable for their condition. Some key precautions include: - **Cardiovascular disease**: Nandrolone, like other anabolic steroids, can negatively affect **cardiovascular health**. It may increase the risk of **heart attack**, **stroke**, and **hypertension**. Patients with pre-existing **heart disease** or **hypertension** should use Nandrolone cautiously, with regular monitoring of heart function and blood pressure. - **Liver function**: Nandrolone is metabolized by the liver and may lead to **liver toxicity** with long-term use. It is important to monitor liver function with regular tests, especially in patients with pre-existing liver conditions. - **Endocrine system effects**: Nandrolone can suppress natural testosterone production, leading to **hypogonadism**, **infertility**, and other endocrine disturbances. Patients should be monitored for these effects, and appropriate hormone replacement therapy may be considered. - **Mental health**: Nandrolone has been linked to psychological side effects, including **mood swings**, **aggression**, and **depression**. Long-term use can also result in **anabolic steroid-induced psychosis**. Caution is advised for individuals with a history of mental health disorders. - **Pregnancy and breastfeeding**: Nandrolone is contraindicated during **pregnancy** and **breastfeeding**. It may cause harm to the fetus and is excreted in breast milk, potentially leading to adverse effects in the infant. - **Prostate conditions**: Use of Nandrolone can exacerbate conditions such as **benign prostatic hyperplasia** (BPH) and increase the risk of **prostate cancer** in susceptible individuals. Men with a history of prostate issues should be carefully monitored.

Indication

Nandrolone is an **anabolic steroid** primarily used for the following therapeutic purposes: - **Anemia**: Nandrolone is used to treat **anemia**, particularly in patients with chronic kidney disease (CKD) or those undergoing chemotherapy. The drug helps stimulate **erythropoiesis**, leading to an increase in red blood cell production. - **Muscle wasting and cachexia**: It is prescribed for patients with severe **muscle wasting** due to chronic diseases like **cancer**, **HIV/AIDS**, or **burns**. Nandrolone helps increase muscle mass and strength in these patients. - **Osteoporosis**: Nandrolone is also used to treat **osteoporosis** in postmenopausal women and other individuals at risk for bone loss. It helps increase **bone density** and reduce the risk of fractures. - **Growth hormone deficiency**: It is sometimes used in the treatment of growth hormone deficiency, particularly in children, to help increase **bone growth** and **muscle mass**. - **Off-label uses**: Nandrolone is sometimes used off-label for enhancing athletic performance and bodybuilding due to its anabolic effects. However, its non-medical use is illegal in many countries and banned in professional sports.

Contra indication

Nandrolone should not be used in the following conditions: - **Pregnancy**: Nandrolone is classified as a **Category X** drug during pregnancy, meaning it is contraindicated due to its potential to cause harm to the developing fetus, including virilization in female infants. - **Breastfeeding**: It is contraindicated during breastfeeding because it is excreted in breast milk and may cause harm to the nursing infant. - **Prostate or breast cancer**: Nandrolone is contraindicated in men with **prostate cancer** or in women with **breast cancer**, particularly hormone-sensitive types. It can stimulate the growth of these cancers due to its **androgenic properties**. - **Severe liver disease**: Nandrolone can exacerbate liver damage, so it should not be used in patients with **active liver disease**, including **hepatitis** or **cirrhosis**. - **Hypercalcemia**: Nandrolone may increase **calcium levels** in the blood and should be avoided in patients with **hypercalcemia** or conditions that predispose to elevated calcium levels, such as **hyperparathyroidism**.

Side Effect

Nandrolone, like other anabolic steroids, can cause a range of side effects, both common and severe: - **Common side effects**: - **Fluid retention**: Nandrolone can cause **edema** and water retention, leading to swelling, particularly in the lower limbs. - **Acne**: The use of Nandrolone may increase sebum production, leading to acne outbreaks. - **Mood swings**: Some individuals may experience mood alterations, including **irritability**, **aggression**, and even **mania**. - **Hair loss**: Nandrolone may accelerate **male-pattern baldness** in men predisposed to this condition. - **Gynaecomastia**: The development of **breast tissue** in men (gynecomastia) is a potential side effect due to the androgenic effects of Nandrolone. - **Severe side effects**: - **Cardiovascular issues**: Long-term use of Nandrolone may increase the risk of **heart attack**, **stroke**, and **high blood pressure**. It can also negatively affect **cholesterol levels**, leading to an imbalance in **HDL** and **LDL** cholesterol. - **Liver damage**: Nandrolone can cause **hepatotoxicity**, including **hepatitis**, **jaundice**, and in rare cases, **liver failure**. Regular liver function tests are recommended. - **Endocrine effects**: Nandrolone can suppress the body’s natural production of testosterone, leading to **hypogonadism**, **infertility**, and **testicular atrophy**. In women, it may cause **virilization** (the development of male characteristics). - **Psychiatric effects**: Long-term use of Nandrolone can cause **depression**, **anxiety**, and **psychosis**, including **roid rage**, where users experience severe irritability and aggression.

Pregnancy Category ID

5

Mode of Action

Nandrolone is an **anabolic steroid**, which means it has two primary effects in the body: - **Anabolic effects**: Nandrolone promotes the **growth of muscle tissue** and helps increase muscle mass by enhancing protein synthesis. It also has a positive impact on **bone density**, making it useful in the treatment of osteoporosis and muscle-wasting conditions. - **Androgenic effects**: Nandrolone is derived from **testosterone**, so it retains some **androgenic** properties, which are responsible for male characteristics such as **facial hair**, **deep voice**, and **body hair**. However, it has a lower androgenic effect than testosterone, which may result in fewer masculinizing side effects, especially in women. Nandrolone works by binding to **androgen receptors** on muscle and bone cells, stimulating the production of **growth factors** that promote cell growth and regeneration. This makes it useful for promoting recovery from physical trauma or illness and for increasing strength and stamina.

Interaction

Nandrolone can interact with several medications and substances, affecting its efficacy and safety: - **Anticoagulants**: Nandrolone may enhance the effects of **anticoagulants** (such as **warfarin**), increasing the risk of bleeding. Patients on blood thinners should be monitored closely for signs of excessive bleeding or bruising. - **Insulin and oral hypoglycemics**: Nandrolone may alter glucose metabolism and reduce the effectiveness of **insulin** or **oral hypoglycemic drugs**. Diabetic patients should closely monitor their blood glucose levels when taking Nandrolone. - **Corticosteroids**: The use of corticosteroids in combination with Nandrolone can increase the risk of **fluid retention**, **high blood pressure**, and **edema**. This combination should be avoided unless closely monitored by a healthcare provider. - **Cytochrome P450 inducers**: Drugs that induce **cytochrome P450 enzymes** (such as **phenytoin** and **carbamazepine**) may reduce the effectiveness of Nandrolone by increasing its metabolism. Dosage adjustments may be necessary. - **Alcohol**: Alcohol can enhance the liver toxicity of Nandrolone, so excessive alcohol consumption should be avoided during treatment.

Pregnancy Category Note

Information not available

Adult Dose

The typical **adult dose** of **Nandrolone** depends on the indication: - **For anemia**: The usual dose is **50–100 mg** every 2–4 weeks, depending on the patient’s response and tolerance. - **For muscle wasting or osteoporosis**: A typical dose is **50 mg every 2–4 weeks**. For more severe cases, higher doses may be used, but care should be taken to monitor for side effects. - **For growth hormone deficiency**: The dosing regimen can vary depending on the specific needs of the patient, typically starting at a **low dose** and gradually increasing.

Child Dose

For pediatric patients, Nandrolone is generally used under strict medical supervision in cases of **growth hormone deficiency** or severe **muscle wasting**. The dosage will be individualized based on the child’s age, weight, and condition but typically starts at a low dose with gradual adjustments. As always, patients should consult their healthcare provider prior to initiating Nandrolone to ensure the proper dosing and to monitor for potential side effects.

Renal Dose

In patients with **renal impairment**, dose adjustments may be necessary. However, Nandrolone’s excretion is largely through the liver, so **renal impairment** does not significantly affect its dosing. Nonetheless, close monitoring of renal and hepatic function is recommended in these patients.

Administration

Information not available