CASPOFUNGIN ANFARM 50 mg Price in UAE

Overview

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This medicine contains an important and useful components, as it consists of
Caspofungin acetate is available in the market in concentration

Name

Glucose Monohydatel, Sodium chloride

Precaution

Caution should be exercised when administering glucose monohydrate and sodium chloride solutions to patients with renal impairment, diabetes mellitus, congestive heart failure, or hypertension due to the risk of fluid overload and hyperglycemia. Frequent monitoring of serum electrolytes, fluid balance, and blood glucose levels is advised. Use with care in elderly individuals and in patients receiving corticosteroids or other drugs that affect electrolyte balance. Rapid or excessive infusion may result in dilutional hyponatremia or osmotic diuresis. Solutions should be clear and free from particulates before use; do not administer if discolored or if the container is damaged.

Indication

This intravenous solution is indicated for fluid and electrolyte replenishment in cases of dehydration, sodium depletion, or caloric support. It is commonly used in clinical settings for rehydration following surgery, burns, trauma, or infections when oral intake is not possible. The glucose component provides a readily available source of energy, while sodium chloride helps in restoring extracellular fluid volume and maintaining osmotic balance. It is also used as a vehicle for the administration of compatible intravenous medications.

Contra indication

Contraindicated in patients with known hypersensitivity to any component of the formulation. It should not be used in individuals with hypernatremia, hyperchloremia, or clinically significant fluid retention conditions such as pulmonary edema or congestive heart failure. Use is also contraindicated in patients with uncompensated diabetes mellitus or other glucose intolerance syndromes where intravenous glucose may worsen hyperglycemia. Caution is advised in anuric patients or those with severe renal dysfunction.

Side Effect

Common side effects include local infusion site reactions such as redness, swelling, or pain. Systemic adverse effects may include hyperglycemia, electrolyte imbalance (especially hypernatremia), fluid overload, and edema. Rarely, thrombophlebitis or hypersensitivity reactions may occur. Prolonged administration or overdose may lead to dilutional states, metabolic acidosis, or osmotic diuresis. Inappropriate or excessive administration can result in circulatory overload, particularly in patients with cardiac or renal impairment.

Pregnancy Category ID

Information not available

Mode of Action

Glucose monohydrate serves as a source of calories and energy by entering glycolysis, where it is metabolized into ATP for cellular function. Sodium chloride dissociates into sodium and chloride ions in the body, contributing to extracellular fluid volume and osmolality. Sodium ions aid in nerve transmission, muscle contraction, and acid-base regulation, while chloride ions maintain osmotic pressure and electrolyte balance. Together, the solution restores fluid volume, corrects electrolyte imbalances, and supplies energy during intravenous therapy.

Interaction

This solution may interact with drugs affecting sodium or fluid balance, such as diuretics, corticosteroids, or lithium, potentially increasing the risk of sodium retention or electrolyte imbalance. Insulin requirements may change due to the glucose content, especially in diabetic patients. Concurrent use with hypertonic or hypotonic solutions should be carefully evaluated. Compatibility must be ensured when used as a vehicle for drug administration to avoid precipitation or inactivation of active ingredients.

Pregnancy Category Note

This solution is generally considered safe for use during pregnancy when clinically indicated. It falls under Pregnancy Category C (FDA classification) due to a lack of controlled studies in pregnant women. However, because the components are naturally occurring substances in the body and essential for physiological function, risks to the fetus are minimal when used appropriately. Caution should still be observed to prevent fluid overload and electrolyte disturbances in pregnant patients.

Adult Dose

The typical adult dose depends on the patient's fluid and electrolyte needs and clinical condition. Usually, 500–1000 mL may be infused intravenously over 24 hours. Rate and volume should be adjusted based on laboratory values, hydration status, and comorbid conditions. In critical settings, dose titration must be guided by serum electrolytes and glucose levels. Maximum daily dose should not exceed limits that would cause fluid overload or hypernatremia.

Child Dose

Pediatric dosing should be carefully calculated based on body weight and age. A typical range is 10–20 mL/kg/day, adjusted according to the child’s hydration status, serum sodium, and glucose monitoring. Neonates and infants require particular caution to prevent electrolyte imbalance or glucose-related complications. Continuous infusion rates should not exceed 5–10 mL/kg/hour unless under strict clinical supervision.

Renal Dose

In patients with renal impairment, dose adjustments are necessary to prevent sodium and fluid accumulation. Infusion rates should be reduced, and frequent monitoring of fluid balance and serum electrolytes is essential. Consider alternative formulations with reduced sodium if risk of hypernatremia or fluid overload is high. Avoid use in severe renal failure with oliguria or anuria unless under specialist supervision.

Administration

Administer via intravenous route using sterile techniques. Ensure compatibility with other intravenous drugs before mixing. Infuse at a controlled rate using an infusion pump, especially in children or patients with cardiac/renal impairment. Do not administer the solution if particulate matter or discoloration is observed. Use immediately after opening the container and discard any unused portion. Monitor clinical status and laboratory parameters during administration.