Active Substance: Bumetanide.
Overview
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This medicine contains an important and useful components, as it consists of
Bumetanideis available in the market in concentration
Bumetanide
Pregnancy, lactation; regular monitoring of serum electrolytes (especially potassium, calcium, magnesium); in case of hypokalemia, potassium supplements/potassium-sparing diuretics added. Monitor blood-glucose, BUN, creatinine levels as well as blood counts. Sulfonamide allergy. CHF patients on digitalis, K losing nephropathy, hepatic cirrhosis and ascitis, diarrhoeal states. Lactation: Unknown whether drug is excreted in breast milk; use with caution
Hypertension, Heart failure, Oedema, Nephrotic syndrome
Hypersensitivity, progressive renal failure and anuria, hepatic coma, severe electrolyte depletion.
>10% Hyperuricemia (18%),Hypochloremia (15%),Hypokalemia (15%),Azotemia (11%) 1-10% Hyponatremia (9%),Hyperglycemia (7%),Increased serum creatinine (7%),Variations in phosphorus (5%),Variations in CO2 content (4%),Variations in bicarbonate (3%),Variations in calcium (2%),Dizziness (1%),Muscle cramps (1%),Ototoxicity (1%) <1% Asterixis,Dehydration,Hypotension,Orthostatic hypotension,Pruritus,Rash,Renal failure,Serious skin reactions (ie, Stevens-Johnson syndrome, toxic epidermal necrolysis),Vertigo,Vomiting Potentially Fatal: Encephalopathy (in patients with preexisting liver disease).
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Bumetanide induces diuresis by inhibiting reabsorption of water and electrolytes (sodium and chloride) in the ascending loop of Henle and proximal renal tubule.
Reduced diuretic and natriuretic actions by probenecid. Indometacin blunts action of bumetanide; concurrent usage with antihypertensives may increase risk of orthostatic hypotension. Potentially Fatal: Avoid concurrent usage with ototoxic drugs such as aminoglycoides and nephrotoxic drugs. Reduced lithium excretion via kidneys.
Information not available