Overview

Welcome to Dwaey, specifically on DERMOVATE NN Cream page.
This medicine contains an important and useful components, as it consists of Clobetasol propionate / Neomycin (as sulphate) / Nystatin.
DERMOVATE NN is available in the market in concentration 0.5mg, 5mg, 100000 Units/g and in the form of Cream.

GLAXO is the producer of DERMOVATE NN and it is imported from UK, The most popular alternatives of DERMOVATE NN are listed downward .

Mode Of Action & Indication

Clobetasol Propionate is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis. Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template. Nystatin works by binding to ergosterol in the cell membrane of fungus resulting in a change in the cell wall permeability and leakage of cellular components.

Indication

• Psoriasis
• Eczema
• Severe inflammatory skin disorders

Precaution

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. If used in psoriasis careful patient supervision is important. Scalp Application: Keep away from eye. Flammable. Do not use or dry the hair near a fire or flame.

Side Effects

• Perioral dermatitis
• striae esp in flexures. Dermal and epidermal atrophy esp on the face
• steroid purpura. Potentially Fatal: Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression
• Cushing's syndrome
• diabetes and hypertension.

Contra indication

Long-term treatment of ulcerative conditions, rosacea, pruritus; presence of acute infections. Hypersensitivity.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks