VIRGAN 1.5mg/g Price

Overview

Welcome to Dwaey, specifically on VIRGAN 1.5mg/g page.
This medicine contains an important and useful components, as it consists of
Gancicloviris available in the market in concentration

Name

Ganciclovir

Precaution

Renal impairment; preexisting cytopenias or history of cytopenic reactions to drugs; child; contraceptive precautions to be followed during and at least 90 days thereafter; care in administering only into veins with good blood flow. Avoid contact with the skin and eyes. Maintain adequate hydration during infusion. Monitor WBC and platelet counts regularly during treatment. Eye examinations should be conducted at least once every 4-6 wk during treatment for CMV retinitis. Lactation: excretion in milk unknown; use with caution

Indication

CMV retinitis, Pneumonitis, Cytomegaloviral infections

Contra indication

Hypersensitivity; absolute neutrophil count <500 cells/mm3; platelet count <25,000/mm3; pregnancy, lactation. Not to be used as a bolus inj.

Side Effect

Opthalmic >10% Blurred vision (60%),Eye irritation (20%) 1-10% Punctate keratitis (5%),Conjunctival hyperemia (5%) Intravenous >10% Neutropenia w/ ANC <1000/cu.mm (25-50%),Thrombocytopenia (20%) 1-10% Abnl LFTs,Anemia,Confusion,Headache,Nausea/vomiting,Neuropathy,Paresthesia,Pruritus,Retinal detachment,Rash,Sepsis,Weakness

Pregnancy Category ID

3

Mode of Action

Ganciclovir is a synthetic guanine nucleoside analogue with activity against cytomegalovirus (CMV). It competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase, thus inhibiting viral DNA synthesis.

Interaction

Increased risk of haematologic toxicity w/ zidovudine. May increase serum levels of didanosine. Increased serum concentration w/ probenecid and other drugs that inhibit renal tubular secretion and resorption. Use of IV ganciclovir w/ oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Concomitant use w/ immunosuppressive agents (e.g. azathioprine, ciclosporin, corticosteroids) may result in excessive suppression of bone marrow or the immune system. Generalised seizure may occur when taken w/ imipenem and cilastatin. Concurrent use w/ drugs that inhibit replication of rapidly dividing cells (e.g. dapsone, pentamidine, pyrimethamine, flucytosine, cytotoxic antineoplastic agents, amphotericin B, co-trimoxazole, other nucleoside analogues) may result in additive toxicity.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration