Active Substance: Hydroxyethylrutosides (Oxerutins).
Overview
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This medicine contains an important and useful components, as it consists of
Hydroxyethylrutosides (Oxerutins)is available in the market in concentration
Iron Hydroxide Polymaltose
Before starting iron hydroxide polymaltose, it is essential to consult a healthcare provider to ensure its safe and appropriate use. Important precautions include: - **Iron Overload**: Iron hydroxide polymaltose should not be used in patients with iron overload disorders, such as hemochromatosis or hemosiderosis, as excessive iron can accumulate in the body and cause tissue damage. - **Anemia Diagnosis**: Ensure the anemia is due to iron deficiency before initiating treatment. This medication is specifically designed for iron-deficiency anemia, and it is important to rule out other causes of anemia. - **Liver Disease**: Use caution in patients with liver dysfunction. Although iron hydroxide polymaltose is less likely to affect liver function compared to other forms of iron, liver monitoring may still be necessary in patients with pre-existing liver conditions. - **Gastrointestinal Conditions**: Individuals with gastrointestinal disorders (e.g., peptic ulcers, inflammatory bowel disease, or irritable bowel syndrome) should be monitored closely when taking iron hydroxide polymaltose, as iron supplementation can sometimes exacerbate these conditions. - **Pregnancy and Lactation**: Iron hydroxide polymaltose can be used during pregnancy to treat iron deficiency anemia, but it should only be used under medical supervision. While it is generally considered safe during lactation, it is important to discuss with a healthcare provider whether the benefits outweigh any potential risks. - **Hypersensitivity**: Patients with a known allergy or hypersensitivity to iron compounds or any component of iron hydroxide polymaltose should avoid using it.
Iron hydroxide polymaltose is mainly used to treat iron deficiency anemia. Its primary therapeutic uses include: - **Iron Deficiency Anemia**: It is commonly prescribed for the treatment of iron deficiency anemia, which is caused by insufficient iron levels to produce hemoglobin. This medication helps increase iron levels in the body, improving red blood cell production and alleviating symptoms of anemia such as fatigue, weakness, and shortness of breath. - **Prevention of Iron Deficiency**: Iron hydroxide polymaltose may also be used as a preventive measure for individuals at risk of developing iron deficiency, such as pregnant women, people with poor dietary intake, or those with certain chronic conditions that impair iron absorption.
Iron hydroxide polymaltose should not be used in the following conditions: - **Iron Overload**: It is contraindicated in patients with iron overload disorders such as hemochromatosis, thalassemia, or other conditions that lead to excessive iron storage in the body. - **Anemia of Non-Iron Deficiency Etiology**: If the anemia is caused by something other than iron deficiency (e.g., vitamin B12 or folic acid deficiency, chronic disease), iron supplementation is not appropriate and could worsen the underlying condition. - **Hypersensitivity**: Individuals who are hypersensitive to iron hydroxide polymaltose or any of its components should avoid its use, as allergic reactions could occur. - **Gastrointestinal Disorders**: Iron hydroxide polymaltose should not be used in patients with active peptic ulcer disease or in cases of gastrointestinal bleeding, as it could aggravate these conditions.
Iron hydroxide polymaltose is generally well-tolerated, but it may cause side effects in some individuals. Common and serious side effects include: - **Common Side Effects**: - **Gastrointestinal Distress**: Constipation, diarrhea, abdominal pain, bloating, and nausea are common, especially when starting iron supplements. These symptoms typically resolve as the body adjusts to the supplement. - **Dark Stools**: Iron supplementation often causes dark or black-colored stools, which is harmless and a typical side effect. - **Metallic Taste**: Some individuals may experience a metallic taste in their mouth after taking iron hydroxide polymaltose. - **Serious Side Effects**: - **Iron Toxicity**: Overdose of iron can lead to iron toxicity, characterized by symptoms such as nausea, vomiting, abdominal pain, and even organ damage in severe cases. Iron toxicity is more likely in children and should be treated as a medical emergency. - **Allergic Reactions**: Although rare, hypersensitivity reactions such as rash, swelling, or difficulty breathing may occur and require immediate medical attention. - **Gastrointestinal Bleeding**: In individuals with pre-existing gastrointestinal conditions (such as ulcers), iron supplementation could exacerbate bleeding. Patients should report any severe side effects, particularly symptoms of iron overdose or allergic reactions, to their healthcare provider immediately.
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Iron hydroxide polymaltose is a form of iron supplement used to correct iron deficiency in the body. Its mechanism of action includes: - **Iron Delivery**: It provides elemental iron to the body in a form that is absorbed through the gastrointestinal tract. Once absorbed, iron is incorporated into hemoglobin, the protein in red blood cells that carries oxygen throughout the body. - **Restoration of Hemoglobin**: The body uses the iron from the supplement to produce hemoglobin, which is essential for carrying oxygen in the blood. By restoring iron levels, iron hydroxide polymaltose helps correct the anemia associated with iron deficiency. Unlike other iron formulations, iron hydroxide polymaltose is designed to be less irritating to the gastrointestinal system, reducing the likelihood of side effects such as nausea or constipation.
Iron hydroxide polymaltose may interact with several other medications, potentially affecting its effectiveness or increasing the risk of adverse effects. These interactions include: - **Antacids and Proton Pump Inhibitors (PPIs)**: Medications that reduce stomach acid (e.g., antacids, PPIs) can impair the absorption of iron, making iron hydroxide polymaltose less effective. It is advisable to take iron supplements at least 2 hours before or after taking these medications. - **Tetracyclines and Fluoroquinolones**: Iron supplements may interfere with the absorption of certain antibiotics like tetracyclines (e.g., doxycycline) and fluoroquinolones (e.g., ciprofloxacin). It is recommended to separate the administration of these drugs and iron by 2 to 4 hours. - **Vitamin C**: High doses of vitamin C may enhance the absorption of iron, potentially leading to excessive iron levels in the body, increasing the risk of side effects. - **Levothyroxine**: Iron hydroxide polymaltose may decrease the absorption of levothyroxine, a thyroid hormone replacement. Therefore, it is advised to take levothyroxine at least 4 hours apart from iron supplements. - **Other Iron Supplements**: Taking multiple forms of iron supplements concurrently can increase the risk of iron toxicity. It is important to follow prescribed dosages and avoid unnecessary supplementation.
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The usual adult dose of iron hydroxide polymaltose is: - **For Iron Deficiency Anemia**: The typical starting dose is 100–200 mg of elemental iron per day, which may be taken in divided doses. The dosage may vary depending on the severity of the deficiency and the patient’s response to treatment. - **For Preventive Use**: The usual dose for preventing iron deficiency is typically 50–100 mg of elemental iron per day. Iron hydroxide polymaltose should be taken with food to reduce the risk of gastrointestinal upset, although it may be taken on an empty stomach for better absorption if tolerated.
Iron hydroxide polymaltose may be used in pediatric patients with iron deficiency anemia, but the dose should be adjusted based on age and weight: - **Children (6 months to 12 years)**: The typical dose is 2–4 mg of elemental iron per kg of body weight per day, divided into 1 to 3 doses. - **Children (over 12 years)**: The dose for adolescents is similar to the adult dose, typically 100–200 mg of elemental iron per day, depending on the severity of iron deficiency. The use of iron hydroxide polymaltose in children should always be under the supervision of a healthcare provider to ensure appropriate dosing and monitoring. --- As always, it is crucial for patients to consult their healthcare provider before starting iron hydroxide polymaltose to ensure it is the right medication for their condition and to discuss any potential risks or interactions.
In patients with renal impairment, dose adjustments may be necessary: - **Mild to Moderate Renal Impairment**: No specific dose adjustment is typically required for patients with mild to moderate renal dysfunction. However, iron levels should be monitored regularly. - **Severe Renal Impairment**: In patients with severe renal impairment, close monitoring is necessary, as the absorption and metabolism of iron may be affected. Iron hydroxide polymaltose should be used with caution, and dosage may need to be adjusted based on the patient's iron levels.
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