VECTIBIX 20mg/ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Panitumumabis available in the market in concentration

Name

Adenine .0275 % + Citric Acid Anhydrous .3 % + Dextrose

Precaution

Adenine 0.0275% + Citric Acid Anhydrous 0.3% + Dextrose is typically used as a component in formulations aimed at treating metabolic disorders, including certain deficiencies in nucleic acid metabolism. While this formulation is generally safe, there are specific precautions to consider: - **Pregnancy**: The safety of this formulation during pregnancy has not been thoroughly studied. As a precaution, it should be used during pregnancy only when the potential benefits outweigh the potential risks to the fetus. - **Breastfeeding**: There is no specific information available regarding the excretion of this combination in breast milk. Therefore, caution should be used, and it should only be administered during breastfeeding if the potential benefits justify the risks. - **Renal Impairment**: In patients with renal dysfunction, the administration of dextrose, adenine, or citric acid may need to be adjusted. Dextrose is metabolized through the kidneys, and excessive administration in patients with renal insufficiency could lead to fluid imbalance. Monitoring kidney function is necessary in these patients. - **Electrolyte Imbalance**: Citric acid may affect acid-base balance and potentially lead to hyperkalemia or hypocalcemia in sensitive individuals, especially those with pre-existing electrolyte imbalances or renal disorders. - **Diabetes**: Dextrose may raise blood glucose levels. In diabetic patients, glucose levels should be monitored carefully, and insulin adjustments may be required.

Indication

This combination of adenine, citric acid, and dextrose is primarily used for: - **Treatment of Metabolic Disorders**: The formulation is often utilized in treating conditions related to nucleic acid metabolism, such as deficiencies in purine metabolism. Adenine is a purine base that can help in the synthesis of nucleotides, while citric acid helps maintain pH levels and metabolic balance. Dextrose serves as a source of energy. - **Correction of Metabolic Imbalances**: It is also used in specific conditions where there is a need for metabolic support due to the body's inability to properly metabolize purines or glucose. - **Off-Label Uses**: While it is not commonly used for general indications, this mixture may sometimes be used off-label for metabolic correction or energy support in patients with certain deficiencies in purine or nucleotide metabolism.

Contra indication

This combination should be avoided in the following circumstances: - **Severe Renal Impairment**: Patients with severe renal dysfunction may not be able to process or eliminate dextrose and citric acid effectively. This could lead to fluid overload, electrolyte imbalances, or other complications. - **Hypersensitivity**: If the patient is known to have hypersensitivity or an allergic reaction to adenine, citric acid, dextrose, or any components of the formulation, it should be avoided. - **Diabetic Ketoacidosis**: Dextrose should not be used in patients with diabetic ketoacidosis (DKA) as it could exacerbate hyperglycemia and worsen the condition. - **Severe Electrolyte Imbalances**: Patients with significant electrolyte disturbances, such as hyperkalemia or hypocalcemia, should not use this formulation without medical supervision, as citric acid can alter the acid-base balance and affect calcium and potassium levels.

Side Effect

Side effects of adenine 0.0275%, citric acid anhydrous 0.3%, and dextrose are generally mild but may vary depending on the individual patient's health status: - **Common Side Effects**: - **Hyperglycemia**: Dextrose may cause an increase in blood sugar levels, leading to symptoms such as excessive thirst, frequent urination, or increased hunger in susceptible individuals, especially diabetics. - **Gastrointestinal Distress**: Mild gastrointestinal upset, such as nausea, bloating, or abdominal discomfort, may occur, particularly with higher doses. - **Electrolyte Imbalances**: Citric acid may cause minor disturbances in electrolyte balance, leading to symptoms like muscle cramps or weakness if levels of calcium or potassium become altered. - **Serious Side Effects**: - **Hyperkalemia or Hypocalcemia**: Citric acid may cause a shift in electrolyte levels, leading to more severe issues like elevated potassium or decreased calcium, which could result in arrhythmias or muscle dysfunction. These should be monitored regularly. - **Fluid Retention**: In patients with renal impairment, the dextrose and citric acid may lead to fluid retention, resulting in swelling, increased blood pressure, or kidney complications. - **Management of Side Effects**: Regular monitoring of blood glucose, electrolytes, and kidney function is recommended to detect and manage potential adverse effects. Adjusting doses based on clinical response can help prevent complications.

Pregnancy Category ID

0

Mode of Action

The combination of adenine, citric acid, and dextrose works in several ways to support metabolic functions: - **Adenine**: As a purine base, adenine plays a role in nucleotide biosynthesis. It contributes to the synthesis of DNA and RNA, which are essential for cell division and metabolic activity. In patients with purine metabolism disorders, adenine supplementation can help correct deficiencies. - **Citric Acid**: Citric acid is involved in the citric acid cycle (Krebs cycle), which is central to cellular energy production. It helps maintain pH balance in the body and can also act as a chelator for metal ions. It is useful for maintaining optimal metabolic function. - **Dextrose**: Dextrose is a simple sugar that serves as a key source of energy for the body. It is absorbed rapidly into the bloodstream, providing quick energy for cells, tissues, and organs. It is particularly useful for patients with glucose metabolism issues.

Interaction

- **Other Medications**: Adenine may interact with drugs that affect purine metabolism, including allopurinol or certain chemotherapy agents, which inhibit purine metabolism. These interactions could potentially reduce the effectiveness of the adenine component. - **Dextrose and Insulin**: Dextrose can interact with insulin by increasing blood glucose levels, requiring adjustments in insulin dosing for diabetic patients. - **Citric Acid**: Citric acid may interact with certain drugs, especially those affecting the body's acid-base balance. Care should be taken when using this combination in patients taking medications that influence electrolyte levels, such as diuretics or potassium-sparing agents. - **Renal Dysfunction**: In patients with renal impairment, dextrose and citric acid may affect electrolyte levels or acid-base status. Close monitoring is required in patients with compromised kidney function to avoid complications.

Pregnancy Category Note

Information not available

Adult Dose

The exact dosage of adenine 0.0275% + citric acid anhydrous 0.3% + dextrose depends on the specific medical condition and the clinical need for metabolic support. Typically, it is administered under medical supervision with adjustments based on the patient's health status and metabolic requirements. - **General Dosage**: The formulation is usually given in measured doses tailored to individual metabolic needs, starting with low doses and adjusting based on patient response. Specific dosing regimens should be determined by a healthcare provider. - **Administration Method**: This combination may be administered orally or via infusion, depending on the specific formulation and the patient's medical condition.

Child Dose

- **Pediatric Use**: The use of this formulation in children is typically based on specific clinical indications related to metabolic disorders. Pediatric doses are usually adjusted based on weight, age, and metabolic needs. - **Safety and Efficacy**: Due to the presence of dextrose and citric acid, pediatric dosing requires close monitoring for potential changes in blood glucose levels and electrolyte balance, especially in children with underlying metabolic conditions or kidney dysfunction.

Renal Dose

- **Renal Impairment**: In patients with renal impairment, careful dose adjustment is necessary due to the potential accumulation of dextrose or citric acid. Reduced renal function may lead to altered metabolism and the risk of electrolyte imbalances or fluid retention. - **Monitoring**: Renal function should be monitored closely, including serum creatinine, eGFR, and electrolyte levels. Adjustments may be required based on the patient's renal status.

Administration

Information not available