VASCEPA Price

Overview

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This medicine contains an important and useful components, as it consists of
Icosapent ethylis available in the market in concentration

Name

Guaiphenesin + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride

Precaution

Guaifenesin, pseudoephedrine hydrochloride, and triprolidine hydrochloride are commonly combined in over-the-counter medications for the relief of cold and allergy symptoms such as congestion, cough, and runny nose. However, caution is needed when prescribing or administering this combination to individuals with certain medical conditions. Pseudoephedrine, a sympathomimetic drug, can elevate blood pressure and heart rate, so it should be used with caution in patients with hypertension, cardiovascular disease, hyperthyroidism, or glaucoma. Triprolidine, an antihistamine, can cause sedation and anticholinergic effects such as dry mouth, urinary retention, and blurred vision, which may be more pronounced in elderly individuals. Patients with a history of prostate issues, such as benign prostatic hyperplasia, should be monitored closely due to the risk of urinary retention. Guaifenesin, an expectorant, is generally well tolerated but may cause gastrointestinal upset, so taking the medication with food may help mitigate these effects. Monitoring is particularly important for patients taking medications for other conditions, such as antidepressants (especially monoamine oxidase inhibitors) or anticholinergic agents, as interactions may lead to adverse effects. Pregnant and breastfeeding women should consult their healthcare provider before using this combination, as pseudoephedrine has been associated with potential risks during pregnancy, particularly in the first trimester. This medication may also be contraindicated in young children (under 6 years) due to the risk of severe side effects.

Indication

This combination of guaifenesin, pseudoephedrine hydrochloride, and triprolidine hydrochloride is typically used to treat symptoms associated with upper respiratory tract infections, such as the common cold, allergic rhinitis, and sinusitis. Guaifenesin acts as an expectorant, helping to loosen and thin mucus, making it easier to expel from the respiratory tract. Pseudoephedrine is a decongestant that works by narrowing the blood vessels in the nasal passages, reducing swelling and congestion. Triprolidine is an antihistamine that helps to reduce symptoms of allergy, such as runny nose, sneezing, and watery eyes. This combination is effective in alleviating the broad range of symptoms that accompany respiratory infections and allergic reactions. Off-label uses of this combination may include relief from symptoms of seasonal allergies or environmental irritants, though it is not typically used for conditions outside the respiratory tract. It should not be used for chronic conditions or prolonged use without a healthcare provider’s guidance, as it may mask underlying issues.

Contra indication

This medication is contraindicated in individuals with known hypersensitivity to any of its components, including guaifenesin, pseudoephedrine, or triprolidine. It is also contraindicated in patients with severe hypertension or significant cardiovascular disease due to the vasoconstrictive properties of pseudoephedrine. Individuals with glaucoma, particularly narrow-angle glaucoma, should avoid this combination as the anticholinergic effects of triprolidine may exacerbate intraocular pressure. This combination is not recommended for use in patients with urinary retention or severe prostate enlargement, as the anticholinergic effects can worsen these conditions. Additionally, this combination should be avoided in individuals taking monoamine oxidase inhibitors (MAOIs), as the interaction with pseudoephedrine may lead to dangerous increases in blood pressure. It is contraindicated in children under the age of 6 due to the potential for severe, potentially life-threatening side effects. Pregnant and breastfeeding women should avoid using this medication unless deemed absolutely necessary by a healthcare provider, as pseudoephedrine can pose risks during pregnancy, particularly in the first trimester. The combination should also be avoided in patients with a history of seizures, as pseudoephedrine may lower the seizure threshold in some individuals.

Side Effect

The combination of guaifenesin, pseudoephedrine, and triprolidine may cause a variety of side effects, which can vary in severity. Common side effects include mild dizziness, dry mouth, drowsiness, or nausea. The sedative effects of triprolidine may cause drowsiness or impaired coordination, particularly in elderly individuals, which can increase the risk of falls. Pseudoephedrine may lead to restlessness, insomnia, or increased blood pressure, especially when used in higher doses or in sensitive individuals. Gastrointestinal upset, such as stomach discomfort, may occur due to guaifenesin’s expectorant effects. Other side effects may include urinary retention, blurred vision, or difficulty breathing, which are primarily related to the anticholinergic effects of triprolidine. Serious side effects, although rare, include severe allergic reactions, such as difficulty breathing or swelling of the face, throat, or tongue. If any of these occur, immediate medical attention is required. The use of this combination should be discontinued if side effects become severe or persist. Long-term use of this combination is generally not recommended, as it may mask the underlying cause of symptoms and lead to adverse reactions.

Pregnancy Category ID

3

Mode of Action

The combination of guaifenesin, pseudoephedrine, and triprolidine works synergistically to alleviate multiple symptoms associated with respiratory conditions. Guaifenesin, an expectorant, enhances the clearance of mucus from the respiratory tract by reducing the viscosity of the mucus, which facilitates its removal through coughing. This helps to clear the airways and reduce congestion. Pseudoephedrine acts as a decongestant by stimulating alpha-adrenergic receptors in the smooth muscles of blood vessels in the nasal mucosa, leading to vasoconstriction. This vasoconstriction reduces swelling and congestion in the nasal passages, making it easier to breathe. Triprolidine, an antihistamine, blocks the action of histamine at H1 receptors, which reduces the symptoms of allergy such as runny nose, sneezing, and itchy eyes. By addressing multiple pathways involved in cold and allergy symptoms (mucus production, nasal congestion, and histamine release), this combination provides comprehensive symptom relief.

Interaction

Guaifenesin, pseudoephedrine, and triprolidine may interact with a variety of other medications, leading to either increased side effects or reduced effectiveness. Pseudoephedrine, as a sympathomimetic drug, may interact with other sympathomimetics, such as those used for treating asthma (e.g., albuterol), leading to an increased risk of hypertension, tachycardia, or arrhythmias. It can also interact with medications that raise blood pressure, such as certain antidepressants (e.g., tricyclics, SSRIs) and antihypertensive medications, potentially diminishing their effectiveness. Triprolidine, being an antihistamine, may increase sedation when combined with other CNS depressants, such as alcohol, benzodiazepines, or sedative-hypnotics. This may result in excessive drowsiness and impaired coordination. Additionally, the combination of triprolidine with other anticholinergic drugs (e.g., atropine, scopolamine) can lead to a higher risk of dry mouth, urinary retention, and constipation. There may also be interactions with monoamine oxidase inhibitors (MAOIs), which can lead to dangerous elevations in blood pressure when combined with pseudoephedrine. To minimize the risk of interactions, it is important to consult with a healthcare provider or pharmacist before using this combination with any other prescription or over-the-counter medications, including herbal supplements and vitamins.

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dose for the combination of guaifenesin (200 mg), pseudoephedrine (30 mg), and triprolidine hydrochloride (2.5 mg) is one tablet every 4 to 6 hours as needed, not exceeding 6 tablets per day. This dosing regimen helps to provide symptom relief for the common cold, allergy-related symptoms, and other upper respiratory conditions. The exact dosage may vary based on the severity of symptoms and individual patient needs. For some patients, especially those with underlying conditions such as hypertension or heart disease, lower doses may be recommended to minimize the risk of adverse cardiovascular effects. It is important to follow the prescribed dosage and avoid exceeding the maximum daily limit to reduce the risk of side effects such as hypertension, tachycardia, and CNS depression. Patients should take this combination with a full glass of water and consider taking it with food to minimize gastrointestinal upset.

Child Dose

For pediatric patients, the dosage of guaifenesin, pseudoephedrine, and triprolidine varies depending on the child’s age and weight. This combination is typically not recommended for children under 6 years of age due to the potential for severe side effects. For children aged 6 to 12 years, the usual dose is typically one-half of the adult dose, typically given every 4 to 6 hours as needed, not exceeding the recommended daily limit. In younger children, especially those under 6, other medications or treatments may be more appropriate. Careful monitoring of side effects, such as sedation, increased heart rate, and gastrointestinal symptoms, is necessary when prescribing this combination for pediatric patients. Additionally, parents or caregivers should be advised to avoid giving multiple over-the-counter products containing pseudoephedrine, as this could result in an overdose.

Renal Dose

In patients with renal impairment, dose adjustments for the combination of guaifenesin, pseudoephedrine, and triprolidine may be necessary. Since pseudoephedrine is primarily excreted in the urine, its clearance may be reduced in individuals with renal dysfunction, leading to an increased risk of side effects, such as elevated blood pressure and tachycardia. In cases of moderate to severe renal impairment, it is advisable to reduce the dose or increase the time between doses to minimize the risk of adverse effects. Kidney function should be monitored regularly in these patients. There is no specific dosing recommendation for renal impairment, so individualized adjustments based on the degree of dysfunction and patient response are recommended.

Administration

Information not available