VANSIL 250mg Price

Overview

Welcome to Dwaey, specifically on VANSIL 250mg page.
This medicine contains an important and useful components, as it consists of
Oxamniquineis available in the market in concentration

Name

Rabeprazole

Precaution

Before initiating **Rabeprazole** therapy, patients should consult their healthcare provider to ensure the drug is safe and suitable for their specific condition. Key precautions include: - **Allergic Reactions**: Patients who have had previous allergic reactions to **proton pump inhibitors (PPIs)**, including **rabeprazole**, should avoid using this medication. Symptoms of an allergic reaction include **rash**, **swelling**, and **difficulty breathing**. - **Liver Disease**: Since **rabeprazole** is metabolized in the liver, patients with **severe hepatic impairment** (liver disease) should be monitored closely, and dosage adjustments may be required. - **Bone Health**: Long-term use of rabeprazole can lead to **increased risk of fractures** in the spine, hip, or wrist. It should be used with caution in patients at high risk for bone fractures, such as those with osteoporosis. - **Magnesium Deficiency**: Prolonged use of rabeprazole may result in **low magnesium levels**. Symptoms such as **muscle cramps**, **fatigue**, and **dizziness** should be reported. Magnesium supplementation may be required for patients on long-term therapy. - **Stomach Cancer**: Proton pump inhibitors like rabeprazole can mask symptoms of **gastric cancer**, which is why a thorough evaluation should be performed before starting therapy, especially if the patient has risk factors for gastric malignancies. - **Clostridium difficile**: Prolonged use of rabeprazole, like other PPIs, may increase the risk of **Clostridium difficile-associated diarrhea**, particularly in hospitalized patients. Patients should be aware of signs of **severe diarrhea** and report them to their healthcare provider.

Indication

**Rabeprazole** is primarily prescribed for the management of conditions related to **gastric acid secretion**. It is indicated for the following: - **Gastroesophageal Reflux Disease (GERD)**: Rabeprazole is used to treat **GERD**, a condition where stomach acid frequently flows back into the esophagus, causing **heartburn** and damage to the esophageal lining. - **Peptic Ulcer Disease**: Rabeprazole is used to treat and heal **peptic ulcers** (ulcers in the stomach or duodenum) by reducing stomach acid secretion, which allows the ulcers to heal. - **Helicobacter pylori Eradication**: In combination with antibiotics, rabeprazole is used in the eradication therapy for **Helicobacter pylori** infection, a bacterium that causes **gastric ulcers** and **gastritis**. - **Zollinger-Ellison Syndrome**: Rabeprazole is also used to treat **Zollinger-Ellison syndrome**, a condition where tumors in the pancreas or duodenum cause excessive acid production. - **Erosive Esophagitis**: Rabeprazole helps to treat **erosive esophagitis** caused by **acid reflux**, promoting healing of the esophageal lining.

Contra indication

Certain patients should avoid using **Rabeprazole** due to safety concerns: - **Hypersensitivity**: Rabeprazole is contraindicated in patients who have shown a **hypersensitivity** to **rabeprazole** or any other component of the drug. - **Severe Hepatic Impairment**: Rabeprazole should be avoided in patients with severe liver disease or **hepatic cirrhosis** due to impaired drug metabolism and risk of accumulation. - **Pregnancy and Breastfeeding**: Rabeprazole should only be used during **pregnancy** if the benefits outweigh the risks. It is not recommended for use in **breastfeeding mothers**, as it is excreted in breast milk and may affect the infant. - **Clostridium difficile**: Patients who have a history of **Clostridium difficile-associated diarrhea** may be at an increased risk of recurrence, and rabeprazole should be used cautiously in these individuals. - **Vitamin B12 Deficiency**: Long-term use of **PPIs** like rabeprazole can lead to **vitamin B12 deficiency**. It should be used with caution in patients who have or are at risk for B12 deficiency.

Side Effect

**Rabeprazole** is generally well-tolerated, but it can cause both common and rare side effects. Patients should monitor for and report the following: **Common Side Effects**: - **Headache**: One of the most common side effects, which is usually mild and transient. - **Diarrhea**: Some patients may experience **diarrhea** or changes in bowel habits. - **Nausea**: Mild nausea may occur, especially at the start of treatment. - **Abdominal Pain**: Stomach discomfort, bloating, or gas can occur in some patients. **Severe Side Effects**: - **Clostridium difficile Infection**: Prolonged use of rabeprazole can increase the risk of **C. difficile-associated diarrhea**, a serious gastrointestinal infection. - **Bone Fractures**: Long-term use of rabeprazole has been linked to an increased risk of **bone fractures**, particularly in older adults. - **Hypomagnesemia**: Chronic use of rabeprazole can cause **low magnesium levels**, leading to symptoms such as **muscle cramps**, **tremors**, **irregular heart rhythms**, and **fatigue**. - **Vitamin B12 Deficiency**: Long-term use of PPIs like rabeprazole can decrease the absorption of **vitamin B12**, leading to **deficiency** over time. - **Renal Effects**: **Acute interstitial nephritis**, a kidney condition, has been reported rarely in patients taking PPIs like rabeprazole. - **Liver Dysfunction**: Rare cases of **liver dysfunction**, including **hepatitis** and **liver failure**, have been reported. If any signs of liver issues, such as yellowing of the skin or eyes (jaundice), occur, treatment should be stopped.

Pregnancy Category ID

3

Mode of Action

**Rabeprazole** belongs to the class of drugs known as **proton pump inhibitors (PPIs)**. Its primary mode of action is: - **Inhibition of the Proton Pump**: Rabeprazole works by **irreversibly inhibiting the proton pump** (H+/K+ ATPase enzyme) in the stomach lining. This enzyme is responsible for the final step in the production of **gastric acid**. - **Reduction of Gastric Acid Secretion**: By blocking this enzyme, rabeprazole significantly reduces the secretion of **gastric acid**, which helps alleviate conditions like **GERD**, **gastric ulcers**, and **erosive esophagitis**. - **Acid Control**: The reduction in stomach acid allows for the healing of **ulcers** and prevents the damage caused by acid reflux. By reducing stomach acid, rabeprazole provides symptom relief and promotes the healing of damaged tissues in the stomach and esophagus.

Interaction

Several drugs and substances can interact with **Rabeprazole**, altering its effectiveness or causing adverse reactions: - **Drugs That Affect Stomach pH**: Rabeprazole, as a proton pump inhibitor, works by reducing stomach acid. **Antacids** or other PPIs may reduce its effectiveness if used concurrently. - **Clopidogrel**: Rabeprazole can reduce the effectiveness of **clopidogrel**, an **antiplatelet** drug, by inhibiting the enzyme **CYP2C19**, which is required for clopidogrel's activation. This may increase the risk of blood clot formation. - **Methotrexate**: High doses of **methotrexate**, a chemotherapy drug, may interact with rabeprazole by increasing the concentration of methotrexate in the blood, raising the risk of toxicity. - **Digoxin**: Rabeprazole can increase the serum concentration of **digoxin**, a medication used for heart failure, potentially leading to **digoxin toxicity**. - **Antifungals and HIV Medications**: Rabeprazole may interact with certain **antifungal medications** like **ketoconazole** and **itraconazole**, and **HIV medications** like **atazanavir**, by altering stomach pH and decreasing their absorption. - **Warfarin**: Rabeprazole can enhance the effects of **warfarin**, increasing the risk of **bleeding**. Regular monitoring of **INR** is recommended.

Pregnancy Category Note

Information not available

Adult Dose

The typical **adult dose** for **Rabeprazole** is: - **GERD**: The standard dose is **20 mg** once daily, usually taken before a meal, for 4 to 8 weeks, depending on the severity of symptoms. - **Peptic Ulcer Disease**: The usual dose is **20 mg** once daily for 4 to 8 weeks, depending on the severity and healing process. - **Helicobacter pylori Eradication**: Rabeprazole is commonly prescribed in combination with **antibiotics** (e.g., **clarithromycin** and **amoxicillin**) for **7 to 14 days**. - **Zollinger-Ellison Syndrome**: The dose starts at **60 mg** once or twice daily, with the potential to adjust based on the patient's response.

Child Dose

The recommended pediatric dose of **Rabeprazole** depends on the child's condition and age: - **GERD in Children**: For children aged **1 year and older**, the usual dose is **10 mg** once daily, which may be increased to **20 mg** based on response and the doctor's recommendation. - **Peptic Ulcer Disease**: The typical dose for children older than **12 years** is **20 mg** once daily, taken for up to 8 weeks. Always consult a healthcare provider before starting **rabeprazole** for children, as individual needs may vary.

Renal Dose

Patients with **renal impairment** typically do not require a dose adjustment for **Rabeprazole**. However, **close monitoring** is recommended for those with **severe kidney disease**, as the drug is excreted primarily through the liver.

Administration

Information not available